frontotemporal lobar degeneration (FTLD)
Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration
... both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis ...C9orf72-associated FTLD/ALS (C9FTLD/ALS) patient ...
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Spatial patterns of phosphorylation-dependent TDP-43-immunoreactive neuronal cytoplasmic inclusions (NCI) in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)
... A major feature of the anatomical structure of the cerebral cortex is the replicated local neural circuit (represented by ‘columns’ or ‘modules’) (Hiorns et al. Table 2. Summary of spatial patterns exhibited by the ...
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Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlates
... Frontotemporal Lobar Degeneration (FTLD) refers to a spectrum of heterogeneous conditions ...dominant frontotemporal atrophy ...involved, FTLD presents with anomia, and the ...
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Neuronal cytoplasmic inclusions in tau, TDP-43, and FUS molecular subtypes of frontotemporal lobar degeneration share similar spatial patterns
... in FTLD-tau than in FTLD- Table ...of frontotemporal lobar degeneration (FTLD): FTLD-tau, ...corticobasal degeneration (CBD), FTLD-TDP, and ...
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Frontotemporal lobar degeneration: current perspectives
... term frontotemporal lobar degeneration (FTLD) refers to a group of progressive brain diseases, which preferentially involve the frontal and temporal ...behavioral-variant frontotemporal ...
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Progranulin in frontotemporal lobar degeneration and neuroinflammation
... Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar ...
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Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
... Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying ...
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Lang, Christina (2016): Transmembrane protein 106B, a risk factor in frontotemporal lobar degeneration, is a lysosomal type II transmembrane protein and affects autophagy. Dissertation, LMU München: Medizinische Fakultät
... N. R., Dickson, D. W., Rademakers, R., Boeve, B. F., Grossman, M., Arnold, S. E., Mann, David M A, Pickering-Brown, S. M., Seelaar, H., Heutink, P., van Swieten, Murrell, J. R., Ghetti, B., Spina, S., Grafman, J., ...
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A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)
... Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, REiman EM, Woodruff BK, Cummings J, ...
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Genetic Regulation Of Tmem106b In The Pathogenesis Of Frontotemporal Lobar Degeneration
... in FTLD-TDP that either directly or indirectly affect TMEM106B ...in FTLD pathogenesis, animal models may be required in order to determine the specific role of these miRs, as well as TMEM106B levels, in ...
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Progranulin axis and recent developments in frontotemporal lobar degeneration
... Although there is emerging evidence for an important role of PGRN in the CNS, the possible molecular mechanism(s) linking PGRN haploinsuffi ciency to TDP-43 dysfunction and/or pathology remain unclear; however, several ...
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Cortical Morphometric Subclassification of Frontotemporal Lobar Degeneration
... Participants were recruited retrospectively from the Memory Clinic at the Karolinska University Hospital. All subjects went through the standard investigation procedure for patients referred to the memory clinic, which ...
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Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
... in FTLD-U, we per- formed immunohistochemical analysis using our specific N-terminal polyclonal ...of FTLD-U and control cases (Figure ...of FTLD-U cases, we identified numerous fibrillar thread-like ...
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Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration
... non-monogenic FTLD has been identified ...with FTLD have produced variable ...for FTLD development are controver- ...in FTLD; others have found no relation- ship between ApoE genotype and the ...
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Prognostic importance of apathy in syndromes associated with frontotemporal lobar degeneration
... of FTLD 10 present new opportunities to un- derstand the determinants of poor survival, whether for dis- orders associated with primary tauopathies (PSP, CBS, nonfluent variant PPA, and half of bvFTD) or TDP-43 ...
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Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration
... for FTLD pathology do not exist, with the exception of decreased progranulin concentrations in serum or plasma for GRN mutation-related FTLD, an important subgroup of FTLD-TDP [12, ...and FTLD ...
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Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes
... of FTLD-associated disorders, special consideration is required when applying the criteria to cases that lie at a bound- ary between 2 categories, or who present with an overlap of clin- ical ...
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Role of MAPT mutations and haplotype in frontotemporal lobar degeneration in Northern Finland
... either FTLD or eoAD were two-fold compared with those in the controls, and that the frequencies of both the H2 allele and the H1/H2 + H2/H2 genotypes were signifi- cantly higher in both patient ...corticobasal ...
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White matter change with apathy and impulsivity in frontotemporal lobar degeneration syndromes
... One difference between the former volumetric study and cur- rent DTI results is the absence of a tract-based deficit in relation to patients’ observations of their own symptomatology (table 3). 3 There are several ...
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Caudate Nucleus Volumes in Frontotemporal Lobar Degeneration: Differential Atrophy in Subtypes
... The clinical implications of our findings relate to the neu- ropathophysiology of FTLD and the functional significance of the caudate nucleus. Decreased caudate volume is associated with poorer cognition and may ...
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