Fusion and entry
Paramyxovirus Fusion and Entry: Multiple Paths to a Common End
... Membrane Fusion For paramyxoviruses to gain access to the host cell, they must overcome two lipid barriers that separate the genomic contents of the virus from the ...during entry, a process that is very ...
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Ebolavirus Entry Requires a Compact Hydrophobic Fist at the Tip of the Fusion Loop
... I fusion proteins in being an internal loop maintained by a disul- fide bond, as opposed to being a more typical N-terminal fusion ...cell entry, calorimetry, and molecular simulation ...short ...
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A Polymorphism within the Internal Fusion Loop of the Ebola Virus Glycoprotein Modulates Host Cell Entry
... this entry phenotype. Position 544 resides within the internal fusion loop and was previously reported to be essential for efficient membrane fusion and entry ...internal fusion loop ...
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Association of Vaccinia Virus Fusion Regulatory Proteins with the Multicomponent Entry/Fusion Complex
... a fusion regulatory role as deletion or mutation of either causes infected cells to form large syncytia sponta- ...described entry fusion complex (EFC), which are also required for virus-cell ...
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Vaccinia Virus A56/K2 Fusion Regulatory Protein Interacts with the A16 and G9 Subunits of the Entry Fusion Complex
... spontaneous fusion of infected cells to form large multinucleated ...VACV entry fusion complex (EFC); this association has been proposed to prevent the fusion of infected ...
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N-Glycans on Nipah Virus Fusion Protein Protect against Neutralization but Reduce Membrane Fusion and Viral Entry
... and fusion (NiV-F) envelope glycoproteins mediate both syncytium formation and viral ...paramyxovirus fusion proteins are generally required for proper conformational integrity and biological ...viral ...
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Mutagenesis of the fusion peptide-like domain of hepatitis C virus E1 glycoprotein: involvement in cell fusion and virus entry
... The entry of both HCVpp and HCVcc is mediated by E1 and E2 in a pH-dependent manner ...membrane fusion event, where the viral envelope fuses with an endosomal membrane by an as yet unidentified ...membrane ...
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Vaccinia Virus G9 Protein Is an Essential Component of the Poxvirus Entry-Fusion Complex
... We used a second method to investigate the membrane association of G9 that did not depend on its solubility in a nonionic detergent. MVs were purified from cells infected with vG9i in the presence of IPTG and ...
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Acid-Resistant Bovine Pestivirus Requires Activation for pH-Triggered Fusion during Entry
... initiates fusion with the endosomal ...into fusion with the plasma membrane is compatible with the remarkable resistance of pestiviruses to inactivation by low ...allowed fusion from without at low ...
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Foamy Virus Envelope Glycoprotein-Mediated Entry Involves a pH-Dependent Fusion Process
... Env-mediated entry process is different at least in some aspects from that of ...Env-mediated fusion may take place in a different endosomal compartment from the VSV-G-mediated fusion ...virus ...
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The Human Metapneumovirus Fusion Protein Mediates Entry via an Interaction with RGD-Binding Integrins
... a fusion-competent form that mediates low levels of virus ...and fusion. However, we were able to compare F-RGD and F-RAE VLP fusion kinetics, and we found that the integrin- FIG 9 Productive HMPV ...
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A Heptad Repeat in Herpes Simplex Virus 1 gH, Located Downstream of the α-Helix with Attributes of a Fusion Peptide, Is Critical for Virus Entry and Fusion
... the fusion that leads to virus entry and to cell-cell fusion, we searched for substitutions that would abolish the probability of forming the coiled ...
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Crystal Structures of Beta- and Gammaretrovirus Fusion Proteins Reveal a Role for Electrostatic Stapling in Viral Entry
... Viral Entry Halil Aydin, Jonathan ...Membrane fusion is a key step in the life cycle of all envelope viruses, but this process is energetically unfavorable; the trans- membrane fusion subunit (TM) of ...
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Activation of Fusion by the SER Virus F Protein: a Low-pH-Dependent Paramyxovirus Entry Process
... virus entry even though it is unable to induce syncytium ...the fusion-active conformation may not occur as efficiently at neutral pH or physiological temper- ature but may be triggered by exposure to ...
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Murine Coronavirus Requires Lipid Rafts for Virus Entry and Cell-Cell Fusion but Not for Virus Release
... virus entry and cell-cell fusion of mouse hepatitis virus (MHV), suggesting the importance of lipid rafts in MHV replication ...MHV entry occurs at a step following virus ...cell-cell fusion ...
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Dissection of Human Immunodeficiency Virus Type 1 Entry with Neutralizing Antibodies to gp41 Fusion Intermediates
... investigate fusion-inducing conforma- tional changes in ...the fusion intermediates at the interface of effector-target (E/T) or virus-target cell membranes (steric problem), or that fusion may occur ...
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Closing two doors of viral entry: Intramolecular combination of a coreceptor and fusion inhibitor of HIV 1
... bifunctional fusion inhibitor, BFFI, is an antibody-based entry inhibitor that combines the activity of an anti-CCR5 monoclonal anti- body with the activity of a fusion inhibitor in one mole- ...the ...
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Amphotericin B derivative blocks human immunodeficiency virus type 1 entry after CD4 binding: effect on virus-cell fusion but not on cell-cell fusion.
... virus-cell fusion could not be ruled out from its lack of action in syncytium formation ...HIV-1 entry in an indirect assay, on the basis of the recently observed property of HIV-1 particles to induce ...
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Vaccinia Mature Virus Fusion Regulator A26 Protein Binds to A16 and G9 Proteins of the Viral Entry Fusion Complex and Dissociates from Mature Virions at Low pH
... Despite the fact that virus strain-related variations of MV entry pathways were well documented, the reason behind this phenom- enon was not known. Using several vaccinia virus strains, we re- cently demonstrated ...
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Inhibition of Nipah Virus Infection In Vivo: Targeting an early stage of paramyxovirus fusion activation during viral entry
... cell entry process, receptor binding triggers conformational changes in the fusion protein (F) leading to viral and cellular membrane ...inhibit fusion by preventing formation of the fusogenic ...
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