Fusion gene
Advances in Fusion Gene Research and Fusion Gene Families in Hematological Malignancies
... Fusion genes (FGs) are major molecular biological abnormalities in hematological malignancies and have become well-established molecular markers for disease classification, risk stratification, and targeted ...
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<italic>In vivo</italic> analysis of the ETV6-CBFA2 fusion gene
... the fusion gene would be controlled after the specific chromosomal ...encoded fusion products associated with a variety of haematological ...in-frame fusion of AF9 with MU were generated. Mice ...
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Characterization of Iranian Avian Metapneumovirus Based on Fusion Gene (F)
... Total RNA was extracted from tissue with the RNeasy mini kit (Qiagen, Germany) according to manufacturer′s instructions and then stored at -70. The cDNA was synthesized using RevertAid first strand cDNA synthesis Kit ...
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JAFFA: High sensitivity transcriptome-focused fusion gene detection
... Fifty fusion events were simulated, with a range of coverage ...out fusion events - the BEERS ...from fusion gene were generated with a MiSeq error profile using ART [34] and combined with a ...
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<p>Gene Therapy with Cytosine Deaminase and Endostatin Fusion Gene Mediated by Endothelial Progenitor Cells in Hepatomas</p>
... ES fusion gene were studied in mouse hepatoma models and the feasibility of this techni- que was evaluated as a potential therapeutic approach for ...
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Molecular characterization of partial fusion gene and C terminus extension length of haemagglutinin neuraminidase gene of recently isolated Newcastle disease virus isolates in Malaysia
... The phylogenetic relationship result showed that the 3 Malaysian isolates recovered in 2006 and 2007; belong to genotype II and VII. Closer phylogenetic relationship of genotype VII viruses suggests that isolate MB043/06 ...
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8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
... three fusion transcripts between PVT1 exon 1a and NSMCE2 exon 3 in the patient (Figure 1d and e), and a fusion gene between exon 6 of NSMCE2 and exon 1 of BF104016, a noncoding RNA sharing the ...
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Novel GTF2I–PDGFRB and IKZF1–TYW1 fusions in pediatric leukemia with normal karyotype
... PDGFRB-fusion gene which we set out to find using RNA ...two fusion transcripts: The first was a novel in-frame GTF2I–PDGFRB fusion tran- ...GTF2I gene with two pseudogenes, GTF2IP1 and ...
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Heterogeneity in the inter tumor transcriptome of high risk prostate cancer
... a fusion gene candidate: (1) must be predicted to have arisen from genome re- arrangement, rather than via a readthrough event; (2) must be predicted in no more than two sequence libraries (with the ...
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Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast.
... recurrent fusion gene(s) or mutations in 273 genes recurrently mutated in breast ...high-confidence fusion genes, eight of which were validated and two of which were ...in-frame fusion genes ...
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Clinical and epidemiological study of EGFR mutations and EML4-ALK fusion genes among Indian patients with adenocarcinoma of the lung
... A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the intracellular domain of anaplastic lymphoma kinase (ALK), named EML4-ALK, has been identified in a subset of ...
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The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus nucleoprotein NP is a nonconventional nuclear localization signal.
... sion gene and the NPI-1 or NPI-3 fusion gene were cotrans- fected into yeast cells together with a reporter plasmid express- ing b-galactosidase. Transformants were then transferred to X-Gal plates ...
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Article - Encoding of BT (Bacillus thuringiensis) pro tein by fu sion gene
... cry1Ac-vip3Aa14 fusion gene plasmid : We constructed translational fusion of two different Bt toxins, which are having different toxicity spectrum and evaluated its toxicity on target ...of ...
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Analysis of Promoter Function in Aspergillus fumigatus
... other fusion gene ...Additionally, fusion genes FIG 1 Map of promoter-reporter fusion gene ...promoter-reporter gene construct consisted of the ...reporter gene, followed ...
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Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer.
... of fusion genes in breast cancer has focused upon identifying fusions via DNA/RNA sequencing, there is much less emphasis given to demonstrating that the fusions identified are oncogenic or modulate therapy ...the ...
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Genetic Analysis of the Major Capsid Protein of the Archaeal Fusellovirus SSV1: Mutational Flexibility and Conformational Change
... We previously showed that deletions of the gene for the minor capsid protein, vp3 in SSV1 led to the production of longer and thinner virions. Fully 99% of these mutant viruses were abnormal, as defined by ...
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Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature
... The recently recognized renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children. They comprise at least ...
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Transactivator IE1 Is Required for Baculovirus Early Replication Events That Trigger Apoptosis in Permissive and Nonpermissive Cells
... fected with dsRNA and infected 24 h later with wt/lacZ, an AcMNPV recombinant in which a polh promoter-driven lacZ reporter replaced the polh gene (Fig. 1). Immunoblot analysis indicated that control egfp dsRNA ...
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Unraveling the diversity of sedimentary sulfate-reducing prokaryotes (SRP) across Tibetan saline lakes using epicPCR
... rRNA gene amplicons and epicPCR (16S rRNA+dsrB gene) amplicons, respectively, from 31 samples (Table ...rRNA gene amplicons for the entire microbial community and epicPCR for SRP, ...
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Dual-Tagging Gene Trap of Novel Genes in Drosophila melanogaster
... reporter gene. Gal4 reporter gene expression as de- tected by UAS-lacZ is shown in three gene-trap lines, GTexp16- #8 (A–C), GTexp7-#77 (D–F), and GTexp49-#2 (G–I), which revealed expression in ...
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