G-quadruplex structure
Supramolecular assembly and metal coordination in G quadruplex structures : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry, Massey University, Manawatu, New Zealand
... The stabilisation of a DNA duplex by coordination of silver(I) ions to cytosine nucleotides was observed. However, this interaction was not useful in directing the assembly of a G- quadruplex ...
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An Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs
... ABSTRACT This technical report describes the development of an aptamer for sens- ing azole antifungal drugs during therapeutic drug monitoring. Modified synthetic evolution of ligands through exponential enrichment ...
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Structural transformation induced by locked nucleic acid or 2′–O-methyl nucleic acid site-specific modifications on thrombin binding aptamer
... of G- quartet construction (Additional file 2: Figure S1), and optional modified sites (except for ion ...the G-quadruplex conformation mostly depends on the glycosidic conformation of guanine ...
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Towards understanding of polymorphism of G-rich region of human papillomavirus type 52
... of G-rich sequence from HPV type 52, which is one of the most relevant HPV types especially in (Southeast) Asia, where it causes up to 20 % of all cervical cancer ...[30]. G-rich oligonucleotide found in ...
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General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter
... on structure – function studies of genetic sequences and the molecular mechanisms of ...several G-quadruplex-forming sequences in human gene promoters (including a partial sequence of Bcl-2, Pu39WT) ...
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Qualitative SERS analysis of G-quadruplex DNAs using selective stabilising ligands
... into G-quadruplex DNA structures in vitro and more recent studies have shown that quadruplexes have certain functions in ...2 G-quadruplexes are involved in regulating telomere maintenance, as well ...
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view Hemin/G-quadruplex DNAzyme for Designing of Electrochemical Sensors
... hemin/G-quadruplex structure acting as NADH oxidase and HRP-mimicking DNAzyme simultaneously, they developed a pseudo triple-enzyme cascade electrocatalytic electrochemical aptasensor for thrombin ...
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A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region
... that G-quadruplex structure might be induced by Ber8 in the double-stranded ...telomere G-quadruplex may lead to alterations of telomere protein binding and telomere uncapping and, ...
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Formation of G-quadruplex and Its Utilizing for an Automated Spectrometric Detection of Cisplatin
... the G- quadruplex structure and disrupt the DNAzyme activity (schematically shown in ...with G-quadruplex using spectrophotometry assay and electrochemical measurement employing the ...
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Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo
... We used a pair of cell models (lymphoma cell line CA46 and Ramos cell line) with differences in the c-myc promoter region sequence for experimental comparisons [26]. The CA46 cell line, which is deficient in the partial ...
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Chiral metallohelices enantioselectively target hybrid human telomeric G quadruplex DNA
... hybrid G-quadruplex of Tel22, the interac- tions of other enantiomeric metallohelices (1b and 2a) with Tel22 were compared (Supplementary Figures S5 and ...antiparallel G-quadruplex of ...the ...
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Modelling the regulation of telomere length: the effects of telomerase and G quadruplex stabilising drugs
... cancer. G-quadruplex (G4) stabilising drugs are a potential anticancer treatment which work by changing the molecular structure of telomeres to inhibit the activity of ...t-loops, ...
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Telomere damage induced by the G quadruplex ligand RHPS4 has an antitumor effect
... Molecules binding to the telomeric G4 structures can also dis- play potent activity against other G4s, such as c-myc promoter (36). A broad view of the gene expression profile in untreated and treated cells demonstrated ...
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QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs
... human G- quadruplexes reported for their post-transcriptional regu- latory roles in different ...2). G-quadruplexes mapped to 5′- or 3′-UTRs in these genes have been reported for their involvement in ...
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Structural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere Sequence
... to quadruplex DNA have shown that compounds that bind strongly to one conformation also stabilize that conformation, as expected from thermodynamic ...highlights G- ...antiparallel structure of HTS ...
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Abolishing HIV 1 infectivity using a polypurine tract specific G quadruplex forming oligonucleotide
... ODN G, is identical to ODN A in the passenger strand with some nucleotide exchanges in the antisense strand to avoid binding to the viral RNA genome (see ...
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Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models
... Before moving toward the in vitro part of our study, we checked whether the binding of our ligands to c-KIT sequences actually impair the processing of c-KIT promoter; for this, we performed a polymerase stop assay. KIT1 ...
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Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment
... to G-quadruplex ...of G- quadruplex RNA on EBNA1 functions in live cells, we first tested the effect of BRACO-19 on EBV genome copy number in latently infected Raji Burkitt lymphoma cells ...
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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
... called G-overhang, can fold into four- stranded G-quadruplex (G4) structures consisting of G- tetrads coordinated around a monovalent cation ...
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Mirror image dependence : targeting enantiomeric G quadruplex DNA using triplex metallohelices
... the structure of metallohelices, but not the electrostatic potential played a predominant role in stabilizing G4 DNA since all the metallohelices carried four positive ...for G-quartet,) than other ...
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