G1 arrest
Fus3p and Kss1p Control G1 Arrest in Saccharomyces cerevisiae Through a Balance of Distinct Arrest and Proliferative Functions That Operate in Parallel With Far1p
... to arrest at Start in G1 phase, the commit- tein kinases may also regulate the G1 to S phase transi- ment point of the cell cycle (Sprague and Thorner tion in parallel with Cdc28p ...from G1 ...
16
Internucleosomal DNA fragmentation during phorbol ester induced monocytic differentiation and G0/G1 arrest
... G0/G1 arrest. These G0/G1 cells displayed characteristics of monocytic differentiation, including down-regulation of c-myc expression and induction of c-fms ...
8
G0/G1 arrest and apoptosis induced by SARS CoV 3b protein in transfected cells
... cycle arrest at G0/G1 phase, and that especially in COS-7 cells, expression of 3b- EGFP was able to induce the increase of sub-G1 phase from 24 h after transfection, which was most obvious at 48 ...
5
Identification and Characterization of FAR3, a Gene Required for Pheromone-Mediated G1 Arrest in Saccharomyces cerevisiae
... Analysis of FAR3 gene expression: Some yeast genes that are involved in the signal transduction pathway o r cell cycle control exhibit transcriptional regulation that is s[r] ...
17
MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function
... cycle arrest mediated by p73 is an important tumor suppression function of ...p73-induced G1 arrest, human bladder carcinoma EJ cells, which lack functional p53 [30, 31], were transfected with a ...
14
<p>Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer</p>
... cycle arrest (both G1/S arrest and G2/M arrest) and cell ...cycle arrest or cell apop- tosis in CRPC cell ...G2/M arrest, it arrested more cells in G1 phase, the effect ...
10
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction
... As mentioned above, our observations suggested that quisinostat had consistent antitumor efficacy in HCC cells through G0/G1 arrest and apoptosis, which was further potentiated when combined with sorafenib. ...
14
<p>Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells</p>
... cell-cycle arrest as determined using fl ow cytometry, which may be related to the regulation of cell-cycle-related proteins p53, CDK2, CDK4, Cyclin D1, Cyclin E, and ...G0/G1 arrest in human AML ...
14
PubMedCentral-PMC4808044.pdf
... cycle arrest and reduced S phase in a dose-dependent manner in the cells ...cycle G1 arrest may be major mechanisms to inhibit cell proliferation in simvastatin treated ovarian cancer ...
15
Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells
... The PI3K/AKT pathway is one of the major signal- ing pathways involved in the progression of various tumors and is associated with cancer progression and invasion [30]. AKT is a key downstream effector of PI3K and is ...
10
Anti-cancer effects of ginsenoside compound k on pediatric acute myeloid leukemia cells
... In order to further demonstrate the effects of compound K on earlier cellular events, we then evaluated Kasumi-1 cell cycle distribution upon compound K treatment. The cells were treated with 20 μM compound K for ...
6
The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelial- mesenchymal transition in breast cancer
... between G1-arrest and apoptosis by inducing cyclin-dependent kinase inhibitor 1 (p21, CDKN1A, CIP1) or pro-apoptotic phorbol-12-myristate-13-acetate-induced protein 1 (Noxa, PMAIP1), ...
19
miR-675-5p enhances tumorigenesis and metastasis of esophageal squamous cell carcinoma by targeting REPS2
... cell G1 arrest, down-regulated CyclinD1 which was correlated with G1-S phase transition and inhibited REPS2/RalBP1/RAC1/CDC42 signaling pathway, which might be responsible for the effect of ...
18
Tissue specific G1 phase cell cycle arrest prior to terminal differentiation in Dictyostelium
... and G1-phase arrest are required for spore cell differentiation or stalk ...that G1 arrest is required for all aspects of prespore differentiation (Fosnaugh and Loomis, 1993; Good et ...
12
p90Rsk is required for G1 phase arrest in unfertilized starfish eggs
... meta-II arrest? As suggested in Dumont et ...meta-II arrest, as Rsk is also activated downstream of the Mos-MAPK pathway in mouse oocytes (Kalab et ...meta-II arrest, cyclin E- Cdk2 is reported to ...
8
A computational model for the coordination of neural progenitor self renewal and differentiation through Hes1 dynamics
... The G1 phase that occurs between nuclear division (M phase) and DNA synthesis (S phase) is a critical cell cycle period during which cells need to interpret a profusion of conflicting signals before deciding on ...
9
Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326
... FGF1 played an oncogenic role in human glioma cells. However, whether FGF1 was involved in the tumor- suppressive effects of HOTAIR knockdown needed to be further studied. Recent studies showed that miR-195 could ...
16
Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest
... cycle arrest in G0/G1 phase in vitro, and this inhibition of proliferation would be in connection with damage of functional integrity of Ca 2+ which induced by STIM1 knock-down (Figures 2 and ...
9
Original Article Zerumbone induces G1 cell cycle arrest and apoptosis in cervical carcinoma cells
... induced G1 cell cycle arrest in SiHa cells in a concentration-depen- dent manner, from 10 mM to 30 mM, which was similar to the findings reporting that zerum- bone induced G0/G1 cell cycle ...
8
SUN1 silencing inhibits cell growth through G0/G1 phase arrest in lung adenocarcinoma
... phase arrest caused by SUN1 knockdown, we detected the expression alterations of some cell cycle-associated ...cycle arrest at G0/G1 phase probably via suppression of Cyclin D1, CDK6, and ...
9