G2/M cell cycle arrest
Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study
... Results: The water extract of C. cicadae (0, 100, 250, 500, and 1000 μ g/mL) inhibited the growth of MHCC97H cells in a dose-dependent manner via G2/M phase cell cycle arrest with no ...
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Euphornin reduces proliferation of human cervical adenocarcinoma HeLa cells through induction of apoptosis and G2/M cell cycle arrest
... A cell viability assay showed that euphornin inhibited proliferation of HeLa cells in a dose-dependent and time-dependent ...the G2/M ...of cell cycles indicated that euphornin induced ...
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CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest
... a cell survival assay which based on the ability of single cells to proliferate indefi- nitely to grow into colonies in ...mines cell reproductive death under radiation or cytotoxic agents-treatment and is ...
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G2/M Cell Cycle Arrest Correlates with Primate Lentiviral Vpr Interaction with the SLX4 Complex
... sion at the level of translation (6, 29), this is not reflected in the replicative capacity of Vpr-defective viruses in activated CD4-pos- itive (CD4 ⫹ ) T cells. In contrast, Vpr-dependent growth pheno- types have been ...
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Reovirus-Induced G2/M Cell Cycle Arrest Requires ς1s and Occurs in the Absence of Apoptosis
... capacity of reovirus strains to inhibit DNA synthesis and in- duce apoptosis are determined by the S1 gene (40, 44). To determine whether apoptosis-associated disruption of cellular DNA is required for reovirus-induced ...
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Vpr Cytopathicity Independent of G2/M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4+ T Cells
... tant, I70S, as well as the other helix three mutants were pre- dominantly cytoplasmic with most cells exhibiting a staining pattern surrounding the nucleus (Fig. 3A and B). Thus, muta- tions in the exposed hydrophobic ...
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Exposure to reduced oxygenation following radiation exposure enhances the survival of prostate cancer cells in vitro: implications for radiation therapy delivery
... We determined that this survival advantage was associated with induction of a G2/M cell cycle arrest, was not associated with increased DNA repair, was associated with reduced induction [r] ...
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Cytotoxic effects of ZnO hierarchical architectures on RSC96 Schwann cells
... significant cell apoptosis in a dose-dependent ...remarkable G2/M cell cycle arrest, even at a sublethal dose (8 μg/mL), implying the early DNA ...the cell culture media ...
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The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest
... of G2/M cell cycle progression, has a LEF1 binding site on its promoter ...blocks cell division in the G2/M ...produce G2/M cell cycle ...
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Reovirus-Induced ς1s-Dependent G2/M Phase Cell Cycle Arrest Is Associated with Inhibition of p34cdc2
... (ICP22) gene products (1), Autographa californica nucleopoly- hedrovirus ODV-EC27 (6, 7), and human papillomavirus E6 and E7 (64) can all increase cdc2 activity. In cases where viruses increase cdc2 kinase activity, it ...
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Original Article Erianin induces apoptosis of colorectal cancer cells via activation of JNK signaling pathways
... carcinoma cell lines, exploring the underlying molecular ...on cell cycle and apoptosis ...of cell cycle and apoptosis-related proteins after erianin ...the cell number at the ...
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Original Article Salidroside induces cell cycle arrest and apoptosis in human cervical cancer SiHa cells
... the G2/M phase dur- ing cell cycling ...the G2/M phase, clearly indi- cate that salidroside preferably induced cell cycle arrest at the G2/M ...the ...
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Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro
... In order to further exlpore the potential mechanism by which shRNA PKM2 affected the lethal effect of docetaxel on tumor cells, flow cytometry was carried out to analyze the cell cycle distribution and ...
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CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration
... cancer cell proliferation and migration in vitro. The total cell number, cell growth rate and DNA synthesis in CCDC34-siRNA lentivirus infected group were significantly decreased or slowed down ...
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Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/M
... Immunofluorescence staining was performed using an established procedure [13]. Briefly, paraffin fixed kidney sections were rehydrated and incubated with primary antibody overnight at 4°C, followed by incubation with ...
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Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells
... cause cell transformation and centrosome amplification when ...caused cell cycle arrest at G2/M phase, and cellular senescence ...
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Cell Cycle Arrest in G2/M Promotes Early Steps of Infection by Human Immunodeficiency Virus
... the cell cycle increased transduction by concentrating viral replication complexes in nondividing ...idea, cell division would dilute early viral intermediates prior to integration, so that after ...
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PubMedCentral-PMC5079804.pdf
... the cell cycle, treated KB-VIN cells were labeled with antibodies against α-tubulin and serine 10-phosphorylated histone H3 (p-H3) as a mitotic chromosome condensation marker and with 4 ...
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Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
... cancer cell proliferation in a dose- and time-dependent manner, induced G2/M phase cell cycle arrest and apoptosis, and inhibited thyroid cancer cell migration and ...
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Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin
... cancer cell lines. We found that CXCR4 silencing significantly inhibited cell growth, decreased colony formation, and enhanced cisplatin sensitivity while overexpression of CXCR4 rendered cells more ...
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