Galectin-1
Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis
... the galectin-7 ...p53-dependent galectin-7 ...allowing galectin-7 ...induced galectin-7 accumulation. High galectin-7 levels in turn rendered MPNST cells more sensitive to apoptotic ...
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Clinical implication of the serum galectin-1 expression in epithelial ovarian cancer patients
... of galectin-1 in EOC tumor ...of galectin-1 was further evaluated using immunohistochem- istry of paraffin-embedded archival tissue specimens and statistical ...the galectin- ...
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LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression
... the galectin-1 protein, was a potential target of ...of galectin-1 partially restored the mobile potential of LYAR knocked-down cells, which suggests that galectin-1 contributed ...
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Identification of galectin-1 as a novel mediator for chemoresistance in chronic myeloid leukemia cells
... that galectin-1 enhances the chemoresistance in CML, we proposed that galectin-1 may decrease the chemosensitivity via increase of MDR1 ...of galectin-1 up-regulated MDR1 ...
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Timing of Galectin-1 Exposure Differentially Modulates Nipah Virus Entry and Syncytium Formation in Endothelial Cells
... of galectin-1’s effect. To gain further insight into how galectin-1 binding to F3 N-glycan mediates its dichotomous role in NiV infection and spread, we modeled a trimeric spike with the ...
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Effect of 5-azacytidine and galectin-1 on growth and differentiation of the human b lymphoma cell line bl36
... that galectin-1 (Gal-1), a 14 kDa galactoside-binding protein distributed widely in im- mune cells, could be involved in these ...the galectin family have been found to modulate cell ...
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Impaired spatial and contextual memory formation in galectin-1 deficient mice
... Brains were perfusion-fixed with 4% paraformaldehyde (PFA), postfixed in the same fixative overnight, and then cut into 50- μ m sections on a vibratome (Leica). After three rinses in PBS, the sections were incubated with ...
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Prognostic significance of galectin-1 expression in patients with cancer: a meta-analysis
... The galectin (Gal) family is a family of endogenous lectins with high affinity for polysaccharides includ- ing β-galactosyl residues and a part of animal lectins in the lectin ...(CRD). Galectin-1 ...
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Nuclear FAM289-Galectin-1 interaction controls FAM289-mediated tumor promotion in malignant glioma
... with Galectin-1, we first examined the regulation of FAM289 and Galectin-1 on each other’s expression and found that they did not affect each other’s expres- sion (Additional file 4: Figure ...
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Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Virus Pathogenesis
... with 1% (vol/vol) of ...Taiwan). Galectin-1 knockout mice with C57BL/6 background were originally deposited to the Mutant Mouse Regional Resource Center (MMRRC) by the Consortium for Functional ...
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Galectin 1 and Superoxide Dismutase are Involved in Wound Healing by Larval Therapy
... Galectin 1 belongs to the family of beta- galactoside-binding proteins, less known than the other two proteins, but so far plays roles such as cell recognition, cellular attachment, and involvement in cell ...
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Galectin-1 is overexpressed in CD133 human lung adenocarcinoma cells and promotes their growth and invasiveness
... Galectin-1 (gal-1), a member of the β-galactoside- binding protein family, is a multifunctional protein capable of regulating multiple processes such as tumor cell adhesion, proliferation, ...
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Oxidized galectin-1 reduces lipopolysaccharide-induced increase of proinflammatory cytokine mRNA in cultured macrophages
... that galectin-1 mRNA is expressed in gingival tissues, and showed that galectin-1 mRNA is significantly increased after challenge with ...that galectin-1 may regulate oral ...
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Original Article Galectin-1: a biomarker of surgical stress in murine model of cardiac surgery
... diluted 1:10 and amplified by real-time PCR using target-specific TaqMan gene expression assays using the 7500 Real- Time PCR system (Applied ...Table 1. Galectin-1 levels in ng/mg of total ...
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Induction of galectin 1 expression by HTLV I Tax and its impact on HTLV I infectivity
... Although galectin-1 concentrations in our infection exper- iments were higher than the measured levels from the supernatant of infected cells, in vivo conditions are likely to differ from our cell culture ...
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Host-Soluble Galectin-1 Promotes HIV-1 Replication through a Direct Interaction with Glycans of Viral gp120 and Host CD4
... protein, galectin-1 (Gal-1), greatly accelerates (as high as 40-fold) the binding kinetics of HIV-1 to susceptible cells, leading to faster viral entry and a more robust viral replication (33, ...
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Serum galectin-1 in patients with multiple myeloma: associations with survival, angiogenesis, and biomarkers of macrophage activation
... Abstract: Galectin-1 (Gal-1) is known to regulate cell signaling within the immune system and may be a target for new anticancer immune ...Keywords: galectin-1, multiple myeloma, ...
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Galectin 1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance
... environment. Galectin-1 (Gal1), a carbohy- drate-binding protein, is highly overexpressed and secreted into the surrounding milieu by solid cancers including lung, melanoma, breast, and HNC ...
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Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008
... of Galectin-1 (also known as L14 lectin) mRNA in the pre-B cell stage decrease notably as the cells further mature, and thus high levels may just reflect an earlier precursor B phenotype ...regulates ...
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Clinical Significance of Serum Galectin 1 and Its Tissue Immunohistochemical Expression in Serous Ovarian Carcinoma Patients
... Objectives: Serous ovarian carcinoma (SOC) is the commonest ovarian car- cinoma type with poor prognosis due to early metastasis and first presenta- tion with advanced stage. In this work, we investigated serum level of ...
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