Galectin-9
SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancer
... through DNMT3A is required for HAVCR2 and LGALS9 transcription. The results showed that overexpressed SUV39H1 increased the methylation levels at the HAVCR2 and LGALS9 promoter regions (Fig. 5a, b), these changed ...
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Astrocyte galectin-9 potentiates microglial TNF secretion
... exogenous galectin-9 could enhance microglial expression of MHC II and CD86 following poly(I:C) stimulation, cells (2 × 10 5 ) were plated onto sterile 35-mm petri-dishes (Falcon; Becton Dickinson, Franklin ...
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A unique role for galectin 9 in angiogenesis and inflammatory arthritis
... Fig. 2 Galectin-9 medium (Gal-9 M) induces human dermal microvascular endothelial cell (HMVEC) tube formation in vitro . a Gal-9 M induced HMVEC tube formation on growth factor-reduced (GFR) ...
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Plasma levels of Galectin 9 reflect disease severity in malaria infection
... Galectin-9 (Gal-9) is member of the galectin family of β-galactoside-binding animal lectins with a conserved carbohydrate recognition domain (CRD) [3]. Gal-9 was first described as an ...
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Developmental regulation, expression, and apoptotic potential of galectin 9, a beta galactoside binding lectin
... Although galectin-9 binding was mediated via b-galactosyl groups (vide supra), direct evidence for the galectin-9–induced apoptosis after its binding with the thymocytes was provided by the ...
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Original Article Expression of galectin-9 mRNA in hepatocellular carcinoma
... that galectin-9 might perform anti- metastasis interventions through tumor cell ...of galectin-9 in patients with colorectal cancer was impacted by distant metastasis of cancer cells ...of ...
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Human Cytomegalovirus Upregulates Expression of the Lectin Galectin 9 via Induction of Beta Interferon
... actosides. Galectin 9 (Gal-9) can modulate diverse biological ac- tivities, including cell adhesion, proliferation, apoptosis, and cell cycle progression ...(8, 9), and infection with ...
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Galectin 9 inhibits TLR7 mediated autoimmunity in murine lupus models
... DCs (pDCs), and abnormal production of autoantibodies by B cells are critical for systemic lupus erythematosus (SLE) pathogenesis. The importance of galectin-9 (Gal-9) in regulating various ...
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A novel monoclonal antibody for detection of galectin-9 in tissue sections: application to human tissues infected by oncogenic viruses
... each galectin-9 isoform (S, M or ...detect galectin-9 including 2E12 and 2D12 (data not ...No galectin-9 was detected in BL2 cells (EBV-negative human B-cells derived from an ...
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Tim-3/Galectin-9 Pathway Involves in the Homeostasis of CCl4 Induced Hepatitis
... Abstract: Acute liver injury refers to diseases caused by various factors such as explosive liver dysfunction and inflammatory reaction caused by various causes, and the main mechanism is unclear. In this study, we found ...
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EZH2 promotes hepatocellular carcinoma progression through modulating miR-22/galectin-9 axis
... exogenous galectin-9undergo apoptosis mediated by the calcium-calpain-caspase-1 pathway ...effects, galectin-9 also inducesHCC cell apoptosisin the absence of Tim-3 ...of galectin-9 in ...
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Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease
... levels increased along with the progression of GFR stages, i.e. G1 to G4. In diabetic kidney disease, albuminuria also increased during the progression of the disease and Gal-9 may be actively filtered through ...
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Restriction of Human Cytomegalovirus Infection by Galectin-9
... ABSTRACT Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. While HCMV infection is generally asymptomatic in the immunocompetent, it can have devastating consequences in those with compromised or ...
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Galectin-9 Functionally Impairs Natural Killer Cells in Humans and Mice
... Real time RT-PCR analysis of human NK cells stimulated by Gal-9. We used real-time reverse transcription-PCR (RT-PCR) to confirm the top 6 genes shown to be maximally differentially ex- pressed (greater than ...
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Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter
... of galectin 9 (Genbank acces- sion number Z49107) using primers containing the start and stop codons (Table 1, first primer ...to galectin 9 was verified by ...
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SUPPLEMENTAL METHIONINE, CHOLINE, OR TAURINE AFFECT GALECTIN GENE EXPRESSION IN ADULT HOLSTEIN COW AND NEONATAL HOLSTEIN CALF NEUTROPHILS IN VITRO
... of galectin-9 has been implicated with promoting migration of macrophage migration during inflammation and (Almkvist and Karlsson ...2002). Galectin-9 contributes to a TH2 cytokine bias by ...
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Expression of galectin-8 on human endometrium: Molecular and cellular aspects
... of galectin-9 on uterodomes suggests that galectin-9 may play a role during the initial events of human embryo implantation ...(21). Galectin 15 is regulated by progesterone and is ...
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Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer
... Methods: We carried out the immunohistochemistry staining of HNSCC tissue microarrays. Through quantification of the histoscore, we performed the correlation analysis among the TIM3, Galectin-9, Foxp3, CD68 ...
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HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling
... and Galectin-7 was further validated with the demonstration that HA-tagged Tid1-L-wt or Tid1-L-mut was co-immunoprecipitated with Myc-tagged Galectin-7 and vice versa with HA-tagged Tid1-L in 293T cells, ...
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Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update
... in galectin-3 has emerged because of its potential role as a ...biotarget. Galectin-3 is differentially expressed depending on the tissue type, however its expression can be induced under conditions of ...
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