Gambogic acid
Gambogic Acid as Anticancer Agent: A Review
... Liver kinase-B1 (LKB1) have tumor suppressing action by regulating the cell growth, survival, metabolism, and polarity. GA has been found to enhance the levels of p-AMPK via up-regulating E-cadherin linked with LKB1 in ...
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Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
... ambiguous roles in various cancers and the mecha- nisms remain unknown [5, 25, 26]. High expression of the autophagy-associated genes, LC3 and Beclin-1, are reportedly associated with a poor prognosis in various cancer ...
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Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)
... of gambogic acid on cell viability, the cell cycle, and apoptosis were assessed using 4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan (MTT) and flow cytometry in pancreatic cancer cell ...of gambogic ...
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Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG<sub>2000</sub> micelles
... study showed that GA-mPEG 2000 micelles were more efficient in suppressing growth of tumors and prolonging the life span of mice compared with GA-L (Figures 6–8). The underlying mechanisms might involve three phases. ...
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Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo
... Abstract: To minimize the side effects and the multidrug resistance (MDR) arising from daunorubicin (DNR) treatment of malignant lymphoma, a chemotherapy formulation of cysteamine-modified cadmium tellurium (Cys-CdTe) ...
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Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer
... Background: Delivery of a high concentration of anticancer drugs specifically to cancer cells remains the biggest challenge for the treatment of multidrug-resistant cancer. Poloxamers and D-α-Tocopheryl polyethylene ...
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<p>Antitumor Activity of Thermosensitive Hydrogels Packaging Gambogic Acid Nanoparticles and Tumor-Penetrating Peptide iRGD Against Gastric Cancer</p>
... In this study, we prepared HPC/SF/Gly drug delivery system loaded with both water-soluble PEG-PCL nanopar- ticles of gambogic acid and iRGD. In vitro drug-releasing experiments showed 20% of GA release and ...
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Gambogic acid-loaded magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1
... utilizing gambogic acid-loaded magnetic Fe 3 O 4 nanoparticles (GA-MNP-Fe 3 O 4 ) on the suppression of ETS1-mediated cell proliferation and migration in Panc-1 pancreatic cancer ...
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Synergistic effect of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> with gambogic acid on apoptosis of K562 leukemia cells
... Abstract: Gambogic acid (GA) has a significant anticancer effect on a wide variety of solid tumors. Recently, many nanoparticles have been introduced as drug-delivery systems to enhance the efficiency of ...
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Inducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles combined with nontoxic concentration of bortezomib and gambogic acid in RPMI-8226 cells
... dimercaptosuccinic acid modified iron oxide (DMSA-Fe 3 O 4 ) magnetic nanoparticles (MNPs) combined with nontoxic concentration of bortezomib (BTZ) and gambogic acid (GA) on multiple myeloma (MM) ...
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<p>Hyaluronic acid-decorated redox-sensitive chitosan micelles for tumor-specific intracellular delivery of gambogic acid</p>
... resin, gambogic acid (GA) has recently been established as a potent anticancer agent that shows signi fi cant inhibitive activities against a variety of cancer cells including ...
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Combination of gambogic acid with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP expression
... therapy. Gambogic acid (GA) could prohibit the proliferation of a variety of human cancer ...Keywords: gambogic acid, cisplatin, drug resistance, lung cancer, lung resistance protein, ...
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Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
... on gambogic acid (GA) and cadmium–tellurium (CdTe) quantum dots (CdTe QDs) modified with cysteamine for purpose of cancer cell labeling and combined ...
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Apoptosis induction associated with the ER stress response through up regulation of JNK in HeLa cells by gambogic acid
... Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid Aungkana Krajarng1,2, Masaya Imoto3, Etsu Tashiro3, Takahiro Fujima[r] ...
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Effects of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> combinated with gambogic acid on apoptosis of SMMC-7721 cells
... Objective: This study aims to investigate the potential benefit of combination therapy with magnetic nanoparticles of Fe 3 O 4 (Fe 3 O 4 -MNP) and gambogic acid (GA) on SMMC-7721 cells. Methods: The ...
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Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
... of gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanopar- ticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) ...
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Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment
... Background: Red blood cell membrane-coated nanoparticle (RBCm-NP) platform, which consist of natural RBCm and synthetic polymeric core, can extend circulation time in vivo with an improved biocompatibility and stability ...
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Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
... Notes: (A) Encapsulation efficiency and yield of GA into PLGA nanoparticles at various initial drug inputs. (B) size of ga-loaded rBc nanoparticles prepared from different rBcm:polymer ratios. For given amounts of ...
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Synergistic anti proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines
... gambogic acid and docetaxel administration. Median effect analysis was applied for determination of synergism and antagonism. Synergistic interaction between gambogic acid and docetaxel was ...
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Synergistic effect of a combination of nanoparticulate Fe<sub>3</sub>O<sub>4</sub> and gambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells
... Gambogic acid (Kanion Pharmaceutical Co, Ltd, Jiangsu, China) was dissolved in dimethyl sulfoxide (Sigma-Aldrich, St Louis, MO), stored at - 20 ° C, and then diluted as needed in RPMI 1640 medium ...
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