Gambogic acid(GB)
Gambogic Acid as Anticancer Agent: A Review
... Liver kinase-B1 (LKB1) have tumor suppressing action by regulating the cell growth, survival, metabolism, and polarity. GA has been found to enhance the levels of p-AMPK via up-regulating E-cadherin linked with LKB1 in ...
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Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG<sub>2000</sub> micelles
... the gambogic acid parts of the molecules were face-to-face (as shown in Figure 4B[a]), the gambogic acid moieties approached each other after 100 picoseconds of Langevin dynamics ...the ...
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Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
... on gambogic acid (GA) and cadmium–tellurium (CdTe) quantum dots (CdTe QDs) modified with cysteamine for purpose of cancer cell labeling and combined ...
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Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer
... Background: Delivery of a high concentration of anticancer drugs specifically to cancer cells remains the biggest challenge for the treatment of multidrug-resistant cancer. Poloxamers and D-α-Tocopheryl polyethylene ...
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Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)
... of gambogic acid on cell viability, the cell cycle, and apoptosis were assessed using 4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan (MTT) and flow cytometry in pancreatic cancer cell ...of gambogic ...
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<p>Antitumor Activity of Thermosensitive Hydrogels Packaging Gambogic Acid Nanoparticles and Tumor-Penetrating Peptide iRGD Against Gastric Cancer</p>
... Gambogic acid (GA) is one of the main components of gamboge, which could have anti-tumor effects in various cancers, such as breast cancer, 11 gastric cancer, 12 liver cancer, 13 and lung ...gic acid ...
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Synergistic effect of a combination of nanoparticulate Fe<sub>3</sub>O<sub>4</sub> and gambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells
... gambogic acid markedly inhibited the activity of PI3K at the transcriptional and translation levels, and that the mRNA of PI3K and the protein of the activated form of PI3K were substantially reduced ...
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Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo
... Abstract: To minimize the side effects and the multidrug resistance (MDR) arising from daunorubicin (DNR) treatment of malignant lymphoma, a chemotherapy formulation of cysteamine-modified cadmium tellurium (Cys-CdTe) ...
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Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
... ambiguous roles in various cancers and the mecha- nisms remain unknown [5, 25, 26]. High expression of the autophagy-associated genes, LC3 and Beclin-1, are reportedly associated with a poor prognosis in various cancer ...
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Combination of gambogic acid with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP expression
... therapy. Gambogic acid (GA) could prohibit the proliferation of a variety of human cancer ...Keywords: gambogic acid, cisplatin, drug resistance, lung cancer, lung resistance protein, ...
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Apoptosis induction associated with the ER stress response through up regulation of JNK in HeLa cells by gambogic acid
... Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid Aungkana Krajarng1,2, Masaya Imoto3, Etsu Tashiro3, Takahiro Fujima[r] ...
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Synergistic anti proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines
... Conclusions: Gambogic acid plus docetaxel produced a synergistic anti-tumor effect in gastrointestinal cancer cells, suggesting that the drug combination may offer a novel treatment opti[r] ...
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Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment
... Background: Red blood cell membrane-coated nanoparticle (RBCm-NP) platform, which consist of natural RBCm and synthetic polymeric core, can extend circulation time in vivo with an improved biocompatibility and stability ...
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Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
... of gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanopar- ticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) ...
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Effects of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> combinated with gambogic acid on apoptosis of SMMC-7721 cells
... Objective: This study aims to investigate the potential benefit of combination therapy with magnetic nanoparticles of Fe 3 O 4 (Fe 3 O 4 -MNP) and gambogic acid (GA) on SMMC-7721 cells. Methods: The ...
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Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
... Abstract: Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical ...glycolic acid) (PLGA) with red ...
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Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening
... contrast, gambogic acid treatment led to complete spheroid dissolution at a ...of gambogic acid that contains its pharmacophoric motif ...
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Cytoplasmic Domain Signal Sequences That Mediate Transport of Varicella-Zoster Virus gB from the Endoplasmic Reticulum to the Golgi
... virus gB that are required for its ER-to-Golgi transport. Native gB or gB containing deletions and specific point mutations in its cytoplasmic domain was expressed in mammalian ...of gB was ...
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Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene
... of gB in cells infected by the HSV-1 Us3 kinase- dead mutation indicated that HSV-2 Us3, like HSV-1 Us3, regu- lated gB intracellular trafficking in HSV-1 (Us3-chimera)-in- fected ...of gB in ...
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Glycoprotein B Cleavage Is Important for Murid Herpesvirus 4 To Infect Myeloid Cells
... acetic acid (PAA) to prevent secondary spread, followed by counting the proportion of eGFP ⫹ cells with a FACSCalibur (BD Biosciences) or Gal- lios (Beckman Coulter) flow cytometer and calculation of the ...
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