GC, glucocorticoid
Understanding the manifestation of diabetes in sub Saharan Africa to inform therapeutic approaches and preventive strategies: a narrative review
... BMI: Body mass index; DM: Diabetes mellitus; FCPD: Fibrocalculous pancreatic diabetes; GADA: Glutamic acid decarboxylase antibodies; GC: glucocorticoid; HOMA: Homeostatic model assessmen[r] ...
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<p>Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors</p>
... effects; GC, glucocorticoid; BMI, body mass index; FDR, false discovery rate; PETALE, Prévenir les effets tardifs des traitements de la leucémie aiguë lymphoblas- tique chez l ’ enfant; SNP, single ...
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Expression of Glucocorticoid Receptor Isoforms (a, β, γ, and p) in Egyptian Primary Immune Thrombocytopenia Patients
... dosages GC. Considering the wide range of side effects of GC, it is important to avoid GC treatment in those patients who will not benefit from its ...of GC are mainly mediated through the ...
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Toxic_Stress_and_Obesity_AG.pdf
... This review will outline the central pathways of HPA axis activity, and subsequent peripheral glucocorticoid (GC) action. Hormonal signals from the periphery including insulin, ghrelin, and leptin will also ...
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Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
... Sexually dimorphic activity and expression of 11  -HSD1 has been described in some studies (33) but not all (34). In our cohort, urinary GC/MS analysis was similar in men and women. Studies examining sex-specific ...
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Interleukin 1 stimulates its own receptor expression on human fibroblasts through the endogenous production of prostaglandin(s)
... We have also demonstrated that glucocorticoid hormones GC markedly increased the number of IL 1 receptors on several cell types including human peripheral B lymphocytes, human dermal fib[r] ...
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Exosomes derived from human CD34+ stem cells transfected with miR-26a prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis
... Under GC treatment, we found that miR-26a- CD34 + -Exos strengthened the osteogenic differenti- ation of BMSCs in vitro, consistent with former re- ...a GC-induced ONFH rat ...in GC-induced ...vent ...
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Glucocorticoid receptor gene polymorphisms and potential association to chronic obstructive pulmonary disease susceptibility and severity
... The GR gene is located on the long arm 31-32 of chromosome 5 [10, 11] and consists of a 110kb region of 10 exons [12]. Up to 50 GR gene polymorphisms are known. Koyano et al [13] described about 50 poly- morphisms of ...
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Influence of bisphosphonate therapy on bone geometry, volumetric bone density and bone strength of femoral shaft in postmenopausal women with rheumatoid arthritis
... In rheumatoid arthritis (RA), bone damage such as ero- sions, juxta-articular osteopenia, as well as generalized osteopenia and osteoporosis are well recognized [1]. Decreased cortical thickness and enlarged total cross- ...
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Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection
... dependent Gc responses in an alternate model of lung inflammation, involving other major immune cell ...that Gc anti-inflammatory actions on immune cell infiltration, cytokine production, worm load and T ...
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Hyperglycemia related to high-dose glucocorticoid use in noncritically ill patients
... 8.33 mmol/L. Besides our study, no other has prospect- ively and closely evaluated the intensity of hyperglycemia. The second issue is the time it takes for hyperglycemia to occur. Of the 13 cases of DM, none occurred in ...
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Glucocorticoid induced osteoporosis
... There is a mismatch between BMD data and fracture data in patients receiving GCs because of the disparity related to the alteration of bone quality. At similar levels of BMD, postmenopausal women taking GCs have ...
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Traditional Chinese medicine versus regular therapy in Henoch Schönlein purpura nephritis in children: study protocol for a randomized controlled trial
... Tripterygium glycoside (TG) is the active ingredient in triptolide and a patented TCM derived from Triptery- gium wilfordii Hook. It is sometimes used as a type of immunosuppressant in children with HSPN. A meta- ...
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Iatrogenic Cushing’s Syndrome Due to Topical Ocular Glucocorticoid Treatment
... Case 1 was an 11-year-old boy who developed CS after 6 months of intensive topical ocular GC therapy. Although this patient was similar in age to our patient, the dose of GC was slightly higher than ours. ...
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Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment
... The parallel PCA analysis on 68 metabolites showed that the loading scores of all 32 significant lysophospho- lipids were larger than 0.4 in the first component, thus highly correlated with each other (Supplementary Fig. ...
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Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1
... of glucocorticoid molecular mecha- nisms is continuing to be ...and GC-inducible gene expression ...endogenous GC inducible genes ...of glucocorticoid- inducible genes assessed; an observation ...
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Glucocorticoid insensitivity as a future target of therapy for chronic obstructive pulmonary disease
... A direct link between genetic mutations and the develop- ment of relative GC insensitivity in COPD has not been established. However, there is evidence that genetic suscep- tibility is likely to play a role in the ...
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A semantics-oriented computational approach to investigate microRNA regulation on glucocorticoid resistance in pediatric acute lymphoblastic leukemia
... with GC resistance in pediatric ...of GC response can potentially result in the discovery of novel molecular markers by which to predict GC resistance and thus to design therapeutic ...in ...
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GC, GC/MS CHARACTERIZATION OF THE ENICOSTEMA LITTORALE
... recorded. GC-MS analysis of methanol extract residues revealed the presence of 2-methoxy ...the GC-MS analysis and Bioinformatics Docking confirms the phytochemical of Enicostema littorale, 1-6-An hydro ...
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gc - domination and GC-domination numbers of a graph
... Sampathkumar,Graphoidal covers of a graph - A creative review, Proceedings of the National workshop on Graph Theory and its Applications, Manonmaniam Sundaranar University, Ti[r] ...
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