GC, glucocorticoids
The significance of macrophage phenotype in cancer and biomaterials
... complexes; GC: Glucocorticoids; TGF: Transforming growth factor; LPS: Lipopolysaccharides; M1: Classically activated, pro-inflammatory cytotoxic macrophages; TLR: Toll-like receptor; IRF: Interferon ...
13
Micronutrients and many important factors that affect the physiological functions of toll-like receptors
... transition; GC: Glucocorticoids; HCV: Hepatitis C virus; HFD: High-fat diet; HIV: Human immunodeficiency virus; IFN- α : Interferon alpha or other symbols; IL-1: Interleukin 1 or other numbers; IRFs: ...
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Sost haploinsufficiency provokes peracute lethal cardiac tamponade without rescuing the osteopenia in a mouse model of excess glucocorticoids
... for GC-induced divergence in bone length and thus ensure comparisons are made at precisely-matched anatomical locations and ...exogenous GC-induced reduction in cortical bone volume at the femur mid-shaft, ...
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Management of glucocorticoids-induced osteoporosis: role of teriparatide
... Abstract: Glucocorticoids (GC)-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, which leads to an increased fracture risk in ...and GC can cause a rapid bone loss, ...
6
Glucocorticoids suppress bone formation via the osteoclast
... Weinstein et al. report that GCs prevent apoptosis of the mature osteoclast (14), which we confirm. The steroid’s antiapoptotic prop- erties are not attended by Akt activation, indicating that an alterna- tive survival ...
10
Glucocorticoids and neonatal brain injury: the hedgehog connection
... against GC-induced neonatal cerebellar injury by induc- ing the enzyme 11βHSD2, which inactivates the GCs corticosterone and prednisolone, but not ...prevent GC- induced pre- or neonatal brain ...
5
Tuberculosis, anti-glucocorticoids and the immune system
... which GC modulate immune system functions are ...that GC inhibit the synthesis and release of immuno regulatory molecules, such as lL-2 and IFNy, by activated cells (Arya ...of GC on immunoregulatory ...
226
Giant cell arteritis: pathogenic mechanisms and new potential therapeutic targets
... Although glucocorticoids (GC) have been the standard-of-care for over six decades, treatment is not curative and is associated with signifi- cant ...
12
Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation
... Glucocorticoids (GC) are known to play an essential role in the response to critical illness. Although absolute adrenal insufficiency is a well recognised, but rare, clinical entity, rela- tive adrenal ...
7
Sequel and therapeutic modalities of leptospirosis associated severe pulmonary haemorrhagic syndrome (SPHS); a Sri Lankan experience
... The standard treatment of leptospirosis includes anti- biotics and supportive care. Supportive care often in- volves intensive care with inotropes, respiratory support and renal replacement therapy (RRT). ...
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Effects of glucocorticoids in Leishmania major infection
... Total RNA extracted from peritoneal cells of mice was reverse transcribed. Complementary DNA samples were amplified using real-time quantitative polymerase chain reaction and SYBR Green detection. Expression of IL-1β, ...
7
Histamine and a Possible Unity of Autonomous Microcirculatory Dilator Responses: Histamine and Autonomous Dilation
... If it is postulated that the princi- pal target of glucocorticoids is the microvascular smooth muscle cell and that these hormones function to reduce the dilator ac[r] ...
6
Facile Fabrication of Pt-Cu Nanoclusters-Decorated Porous Poly(5-cyanoindole) with High Electrocatalytic Activity
... To evaluate the stability of as-prepared catalysts for methanol and formic acid oxidation, the chronoamperometry were performed at the potential of 0.4 V. As shown in Fig. 7A and Fig. 7B, the gradual decreasing current ...
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Glucocorticoid dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice
... a GC-dependent paracrine Wnt signaling to control mesenchymal progenitor cell lineage commitment through the active secretion of Wnt7b and Wnt10b proteins (Zhou et ...
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Variable Efficacy of Glucocorticoids in Congenital Adrenal Hyperplasia
... On the other hand, this study suggests that when dexamethasone is given in doses of equivalent glucocorticoid potency, the ACTH-suppressing potency is about twice that of cortisol. Other[r] ...
8
Metabolic Effects of Exogenous Glucocorticoids in Fasted Man
... of glucocorticoids increased circulating glucose and insulin levels without intensifying total urinary nitrogen ...of glucocorticoids, preventing them from mobilizing body protein stores during ...excessive ...
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The role of glucocorticoids in the regulation of thyroid function in man
... The diurnal variation in thyroidal iodine release previously observed in euthyroid subjects appears to correlate with variations in serum immunoassayable thyrotropin (TSH). The hypothesis is advanced that this diurnal ...
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Coordinating Gene Therapies of Cystic Fibrosis Airway Disease with Anti-Inflammatory and Antimicrobial Cationic Glucocorticoids
... Certain sterol-based cationic lipids demonstrate both anti-inflammatory and antimicrobial characteristics in addition to their abilities to facilitate gene transfer. These characteristics are particularly suited for ...
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Endogenous and Exogenous Glucocorticoids in Experimental Enterococcal Infection
... It is well documented that bacterial infections induce a host glucocorticoid response that suppresses TNF- ␣ production, so the finding that this also occurs within the peritoneal cavities of E. faecalis-infected mice is ...
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Glucocorticoids: do we know how they work?
... mechanisms. Glucocorticoids combine with a cytoplasmic receptor that alters gene expression in two ...that glucocorticoids inhibit signalling in the mitogen-activated protein kinase pathways that mediate ...
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