Gefitinib resistance
Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
... NSCLC is the primary factor of cancer mortality around the world. Hence, there is a pressing need of novel therapeutic strategies due to their relative insensitivity to chemotherapy [11]. The high incidence of EGFR ...
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Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
... and resistance to EGFR TKIs is associated with EGFR overexpression ...In gefitinib-resistant cells, EGFR tyrosine kinase-dependent pathway does not respond to ...drug resistance by interfering EGFR ...
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244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells
... both gefitinib- sensitive and –resistant NSCLC cell lines (Figure 1C, ...human gefitinib-sensitive tumors established a gefitinib- resistant NSCLC PDX mouse ...reduce gefitinib-resistant ...
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Original Article Connexin 43 affects intrinsic gefitinib resistance of NSCLC cells by GJIC
... Abstract: Gefitinib efficiency in non-small-cell lung cancer (NSCLC) therapy is limited as a majority of NSCLC cells with no epidermal growth factor receptor (EGFR) mutations are intrinsic gefitinib ...
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Epithelial-to-mesenchymal transition correlates with gefitinib resistance in NSCLC cells and the liver X receptor ligand GW3965 reverses gefitinib resistance through inhibition of vimentin
... To confirm EMT in GR cells, we performed genome-wide mRNA expression analysis of the parental HCC827 and the GR HCC827/GR-8-1 cells, and EMT markers with altered expression were subject to further analysis. A total of 18 ...
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Original Article Mig-6 overcomes gefitinib resistance by inhibiting EGFR/ERK pathway in non-small cell lung cancer cell lines
... inhibitor gefitinib is widely used for patients with advanced ...drug resistance is a major ...and gefitinib sensitivity, nor has the contribution of up-regulated Mig-6 on the ...
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Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death
... cluding gefitinib, erlotinib and afatinib) produce marked tumor response and improved progression-free survival (PFS) in NSCLC patient harboring activating EGFR mu- tation [4, 43], patients with wild-type EGFR and ...
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Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA
... in gefitinib-resistant cells pro- moted cell apoptosis, and treatment with exosomes ex- tracted from culture medium of resistant cells potently reduced gefitinib-induced cell ...induced gefitinib ...
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<p>Docosahexaenoic Acid Serving As Sensitizing Agents And Gefitinib Resistance Revertants In EGFR Targeting Treatment</p>
... tinib resistance, the combination of Ge fi tinib and ...tinib resistance revertant potentiality of DHA, a Ge fi tinib resistance formation model has been successfully established and applied in the ...
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Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells
... It has been well-documented that STAT3 signaling pathway contributes to Akt activation in response to a number of extracellular and intracellular signals [25]. More recently, STAT3-Akt activation loop has been uncovered ...
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Case Report Primary gefitinib resistance in NSCLC with EGFR combined RB1 mutation: a case report
... Lung cancer is the most common malignancy and leading cause of cancer death worldwide [1]. NSCLC is the largest histological subtype of lung cancer, which accounts for approximately 85-90% of all lung cancers [2]. With ...
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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment with epidermal growth factor receptor tyrosine kinase inhibitors
... developed gefitinib resistance after only 5 months of treatment, which was much less than the median time of 12 months ...drug resistance after taking gefitinib for 1 ...
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FOXM1 confers resistance to gefitinib in lung adenocarcinoma via a MET/AKT-dependent positive feedback loop
... Gefitinib resistance remains a major problem in the treatment of lung ...of gefitinib resistance are not fully ...in gefitinib resistance of lung adenocarcinoma ...to ...
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FGL1 regulates acquired resistance to Gefitinib by inhibiting apoptosis in non-small cell lung cancer
... acquired resistance to these drugs after 9–13 months of treatment [8, ...The resistance to EGFR-TKI can be primary or ...drug resistance include KRAS mutation and different EGFR mutation sites ...
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Metformin sensitizes hypoxia-induced gefitinib treatment resistance of HNSCC via cell cycle regulation and EMT reversal
... with gefitinib, we hypothesized that it might function via regulation of the cell ...µM gefitinib treatment (Figure ...with gefitinib under hypoxic ...to gefitinib resistance; ...
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Case-specific potentiation of glioblastoma drugs by pterostilbene
... Glioblastoma multiforme (GBM, astrocytoma grade IV) is the most common malignant primary brain tumor in adults. Addressing the shortage of effective treatment options for this cancer, we explored repurposing of existing ...
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Associations between ABCG2 gene polymorphisms and gefitinib toxicity in non-small cell lung cancer: a meta-analysis
... Background: Gefitinib is frequently used to treat patients with non-small cell lung cancer (NSCLC) and is excreted out from cells via the ATP-binding cassette transporter ...of gefitinib toxicity in NSCLC ...
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ROS1 amplification mediates resistance to gefitinib in glioblastoma cells
... the gefitinib IC 50 concentration for U87-EGFR is ...U87-EGFR gefitinib- sensitive cells were used as ...the gefitinib resistant ...in gefitinib-resistant cells compared to non-treated ...the ...
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<p>FGFR1 Induces Acquired Resistance Against Gefitinib By Activating AKT/mTOR Pathway In NSCLC</p>
... Previous studies have shown that overactivation of the AKT signaling pathway was a key factor underlying cell tolerance towards ge fi tinib. 26,27 We predicted that FGFR1 also mediated the development of ge fi tinib ...
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Treatment of pancreatic cancer with epidermal growth factor receptor-targeted therapy
... and gefitinib have been asso- ciated with greater efficacy in nonsmall cell lung cancers (NSCLC) bearing activating mutations in the EGFR tyrosine kinase ...
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