Gene Signature
Identification of a 6-gene signature predicting prognosis for colorectal cancer
... panel signature (ART5, FOXD1, HIST3H2BB, TIMP1, EPHA6 and IRX6) for CRC after the univariate and multivariate Cox proportional haz- ards regression analysis on the mRNA expression profile from the CRC, COAD, and ...
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Prognostic value and their clinical implication of 89-gene signature in glioma
... The 89 probe sets corresponded to 89 annotated genes (Supplementary Table S1). So, we could clarify protein interactions of 89 genes in the 89-gene signature. To understand how these genes could be involved ...
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A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma
... The relatively sparse clinical annotation made com- parison with currently used clinicopathological predic- tors difficult. TNM stage and tumour grade, the most commonly used clinical predictors, were available for a ...
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Original Article Identification of a cytokine-cytokine receptor interaction gene signature for predicting clinical outcomes in patients with colorectal cancer
... a gene-mining approach with TCGA and GEO database, we identified an eight-gene signature in cytokine and cytokine receptor interaction signaling pathway, which is sig- nificantly associated with the ...
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Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma
... applied gene co-expression network analysis to 1509 metabolic gene expression data generated from 120 HCC and 180 non-tumor human liver tissues by ...22-carbon-metabolism-gene- signature of ...
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<p>A Six-Epithelial–Mesenchymal Transition Gene Signature May Predict Metastasis of Triple-Negative Breast Cancer</p>
... 6-EMT gene signature to predict TNBC metastasis after NACT was validated with a GEO dataset ...the signature appeared of predictive value in another GEO dataset of TNBC patients who received surgery ...
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A gene signature for post-infectious chronic fatigue syndrome
... gene signature of CFS suggests that three significant path- ways are altered in patients: oxidative stress, apoptosis and viral-like immune ...This gene encodes a CXC chemokine receptor that is ...
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A robust twelve-gene signature for prognosis prediction of hepatocellular carcinoma
... prognostic gene signature was constructed by Lasso‐ penalized Cox regression analysis [15], and the optimal values of the penalty parameter alpha were determined through 10-times cross-validations by using ...
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A 41-gene signature derived from breast cancer stem cells as a predictor of survival
... a gene expression profile of 41-gene markers that is associated with ...41- gene profile performed best as a predictor of DMFS by classifying patients into high-EL and low-EL ...prognostic ...
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Characterization of a P-Rex1 gene signature in breast cancer cells
... Next, we asked if the effects of P-Rex1 on gene expression are mediated by Rac. We reasoned that impairing the GDP/GTP nucleotide exchange should affect MMP10 induction by HRG. To test this hypothesis, we ...
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A 6-gene signature identifies four molecular subgroups of neuroblastoma
... the gene expres- sion patterns of del11q tumours divided into two clinical groups of favourable and unfavourable biology using their previously described prognostic 144-gene expres- sion ...15-miRNA ...
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Alzheimer's disease gene signature says: beware of brain viral infections
... 1 (CR-1), and C-type lectin domain family 16 member A (CLEC-16A) on chromosome 16. Polymorphic variations in each of these genes were individually associated with AD (P values ranging from l0 -16 to 10 -5 ). However we ...
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Claudin-low bladder tumors are immune infiltrated and actively immune suppressed
... in gene expression patterns between breast and bladder cancer (2, 8), we asked whether a claudin-low subtype also exists in bladder ...using gene signatures representative of biologic characteristics that ...
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Gene expression signature of atypical breast hyperplasia and regulation by SFRP1
... Although considered a “ benign ” lesion because pro- gression to invasive cancer is relatively low, AH presage at least 40,000 breast cancer diagnoses annually [1, 68]. Therefore, intervention at this early stage offers ...
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Identification of an eight-gene prognostic signature for lung adenocarcinoma
... the signature was validated in LUAD patients in our hospital. The eight-gene signature enriched the biological progress of cell division, a cancer-related ...new signature, a promising ...
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Type I IFN innate immune response to adenovirus mediated IFN γ gene transfer contributes to the regression of cutaneous lymphomas
... systemic gene therapy approaches (reviewed in ...(transgene-dependent) gene signature in skin CL lesions after adenoviral IFN-γ gene transfer using microarray technology and provide evidence ...
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A 19-Gene expression signature as a predictor of survival in colorectal cancer
... We performed the Elastic Net [23] to the training dataset and compute the risk scores using eq. (5) based on the model estimates to the training dataset and the test dataset. After calculating the risk score for each ...
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Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases
... in gene expression and the GSVA scores of immune cell gene signature were determined through comparison of post-treatment expression (52 weeks in the asthma study and 32 weeks in the COPD study) with ...
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A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients
... Results: The HGS consisted of 14 genes, and demarcated the CRC patients into the high‑ and low‑risk groups. In all three cohorts, patients in the high‑risk group had significantly worse disease free survival (DFS) ...
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PCNA and KLHL21 were mainly enriched in regulation of cell cycle. The five genes TOP2A MKI67 PCNA PRC1 and KLHL21 play important role in breast cancer progression through regulating tumor cell
... invasiveness gene signature [15], followed by survival analysis to study the association between the signature and survival in patients with breast ...
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