Gene targets
Comparative Evaluation of Several Gene Targets for Designing a Multiplex PCR for an Early Diagnosis of Extrapulmonary Tuberculosis
... mycobacterial gene targets such as insertion sequence (IS)6110; IS1081; 16S rRNA DNA; devR (transcriptional regula- tor, Rv3133c); genes encoding 65kDa (heat shock protein 65, hsp65; Rv0440), MPB-64/MPT-64 ...
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Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer
... miR-125b targets ErbB2/Her2, and by also targeting MEMO1 , which interacts with ErbB2/ Her2, miR-125b is regulating two functionally related ...predicted targets, CBX7, DOK4, NMT2 and EGR1, were ...
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TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis
... Regulators of the inflammatory response were also found to be upregulated by greater than 5-fold following intraoc- ular infection with B. cereus. The suppressor of cytokine signaling 3 (SOCS3) was upregulated 10-fold in ...
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Identification of gene targets against dormant phase Mycobacterium tuberculosis infections
... single gene was up- regulated were judged to be less important or anomalous results and, therefore were considered to be lower priority ...state. Targets that show both up-regulation in the dormant state ...
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Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases
... target gene may reside in regula- tory regions such as enhancers that can interact with distant target genes through mechanisms such as chro- matin looping [60, ...
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Colorimetric biosensing of targeted gene sequence using dual nanoparticle platforms
... invA gene target, the biosensor solution changes color from pinkish-red to light ...myfA gene targets, the biosen- sor solution remained pinkish-red without any observable change (Figure ...
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Identification of novel gene and pathway targets for human epilepsy treatment
... In conclusion, our study provided a comprehensive bioinformatics analysis of DEGs and functions which may be involved in the progression of epilepsy. Immune response, complement system and sodium ion transport may play ...
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Automated Pangenomic Analysis in Target Selection for PCR Detection and Identification of Bacteria by Use of ssGeneFinder Webserver and Its Application to Salmonella enterica Serovar Typhi
... molecular targets is no longer limited to the small number of classical phylogeny genes, as the more than 4,000 genomes offer a wide repertoire of potential gene targets for diagnostic, epidemi- ...
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NEW INSIGHTS INTO LATENT TUBERCULOSIS: A PERSISTING GLOBAL HEALTH CHALLENGE
... potential targets should be explored and explicated to limit mycobacterial ...crucial gene targets, vaccination and therapeutic approaches to target latent tuberculosis ...
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High expression of p300 is linked to aggressive features and poor prognosis of Nasopharyngeal Carcinoma
... promotes gene transcription may vary among gene targets, it is not very hard for us to understand that the function of p300 and its underling mechanism(s) to im- pact cancer progression may lead to ...
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Distribution of Clinically Relevant Borrelia Genospecies in Ticks Assessed by a Novel, Single Run, Real Time PCR
... Real-time PCR. Real-time PCR was performed using a LightCycler rapid thermal cycler system (Roche Diagnostics GmbH, Mannheim, Germany). A 296-bp fragment from the gene encoding OspA was amplified. The reverse ...
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Needs and Targets for the multi sex combs Gene Product in Drosophila melanogaster
... permits a more than 10-fold increase in the number of hatching first instar larvae, and in the rescue of adult progeny (Table 3). The adult escapers have abnormal tergites and are mostly fertile. Together these data show ...
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The Gene Master Regulators (GMR) Approach Provides Legitimate Targets for Personalized, Time-Sensitive Cancer Gene Therapy
... tissue in a case of metastatic clear cell renal cell carcinoma, a case of papillary thyroid cancer and two 356. cases of prostate cancer[r] ...
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High efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets
... Adenoviral-mediated gene delivery of a non-degradable IκBα, or dominant negative versions of C/EBPβ or c-Jun, has been examined to determine the contribution of each transcription factor to IL-6 and IL-8 ...
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Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV
... Epigenetic alterations that silence gene expression play an important role in cancer (45). The polycomb repressor system is an epigenetic mechanism that plays a major role in the maintenance of the transcriptional ...
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miR-638 regulates gene expression networks associated with emphysematous lung destruction
... in gene ex- pression associated with varying disease severity within an individual’s ...of gene expression associated with increasing regional emphysema severity within individual lungs ...emphysema ...
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In silico prediction of novel therapeutic targets using gene–disease association data
... unsuccessful targets is extremely difficult, if possible at ...of targets using the Informa Pharmaprojects data [32], we ignored a number of categories relating to drug programmes that had been suspended or ...
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Mixomics analysis of Bacillus subtilis: effect of oxygen availability on riboflavin production
... this gene expression profiling analysis based on time course, a set of genes (pur) were highlighted as they encoded enzymes that catalyze path- ways for riboflavin generation but were inhibited in the later phase ...
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Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening
... complementary gene dosing strategy was utilized to identify genes whose products conveyed resistance to ...the gene dosing (GD) and drug affinity responsive target stability (DARTS) ...
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The Links Between Target-Monitoring Practices And Performance: The Influence Of Job Quality And Job Satisfaction
... Table 2 summarises the variables and their measurement. Measures of targets and monitoring management practices are obtained from the survey of managers. Confirmatory factor analysis (CFA) revealed that target ...
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