genetic case-control data
Genetic association tests: a method for the joint analysis of family and case-control data
... additive genetic effect unaffected by population ...pedigree data by Abecasis et ...the genetic model, sampling plan and population admixture’, 19 in two steps: (1) building a test statistic that is ...
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Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects
... dominant genetic model, a dichotomous exposure prevalence of 10 %, a relative risk for a genotype of ...1:1 case- control ratio, we need thousands of cases and controls to detect multiplicative ...
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Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case–control study
... clinical data be- tween the COPD cases and the control ...the control group was analyzed for Hardy-Weinberg equilibrium (HWE) using chi-square test and exact test, SNPs were excluded from the ...
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Association of HLA-B27 and Behcet’s disease: a systematic review and meta-analysis
... Information Data 5 IranDoc (Iranian Research Insti- tute for Information Science and Technology), Magi- ran and IranMedex electronic databases from January 1975 to Aug 2017 using key words of Behcet’s disease, ...
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Reducing selection bias in case-control studies from rare disease registries
... by genetic and phenotypic heterogeneity hinders the development of appropriate subject groups for study that are controlled for factors such as age, sex, disease severity, and ...longitudinal data with the ...
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Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer
... [14,16-23]. Genetic algorithm (GA) is potential for feature selection for genome-wide scale data- sets [24] and may apply to compute the difference between case and control groups to identify ...
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Breast cancer risk and genetic ancestry: a case–control study in Uruguay
... We confirmed the tri-hybrid nature of the Uruguayan population, which showed contributions from Africans, Native Americans and Europeans. We found that the Structure model assuming a three-way admixture process provided ...
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An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies
... the case control status is extremely correlated with the secondary phe- ...this case, the secondary phenotype is not providing new information compared to the case-control status and ...
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Predictive modeling in case control single nucleotide polymorphism studies in the presence of population stratification: a case study using Genetic Analysis Workshop 16 Problem 1 dataset
... We first preprocessed the data for outlier detection, which resulted in seven controls (D0009324, D0009459, D0005318, D0011466, D0012257, D0006047, and D0012446) marked as outliers. We followed the general ...
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Original Article Association of genetic polymorphisms with pulmonary tuberculosis in a Chinese Tibetan population: a case-control study
... We selected 20 SNPs from GWA studies that were previously reported to be associated with pulmonary tuberculosis. Minor allele frequen- cies of all SNPs were > 5%, in the HapMap of the Chinese Han Beijing (CHB) ...
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Case control association testing by graphical modeling for the Genetic Analysis Workshop 17 mini exome sequence data
... The final estimated graphical model for the first repli- cate is shown in Figure 2. For this data set, our method detected five causal variants on four genes. Our model found three variants associated with disease ...
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Interval estimation of genetic susceptibility for retrospective case-control studies
... Using data summarized in Table 3, the exact interval was found to have the smallest length 5 times out of 8 considered parameter combinations and has the lowest variability 5 times out of ...for data used ...
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Efficient automatic test case generation for data flow testing using neighborhood crossover method in genetic algorithm
... testing. Data flow testing is considered to be a form of structural testing. Data flow testing is based on selecting paths through the program's control flow in order to explore sequences of events ...
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Genetic variations in apoptosis pathway and the risk of ovarian cancer
... Valencia, CA) according to the manufacturer’s protocol. A custom-designed panel of cancer-related genes had been generated in our lab, which covered 12 major cellular signaling pathways and 998 genes, including those in ...
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Haplotype analysis of case-control data
... Marchenko, Y. V., R. J. Carroll, D. Y. Lin, C. I. Amos, and R. G. Gutierrez. 2008. Semiparametric analysis of case-control genetic data in the presence of environmental factors. The Stata ...
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Thinking Twice: Cloning and In Vitro Fertilisation By Dr Helen Watt The Linacre Centre for Healthcare Ethics
... themselves. Genetic similarity must not be confused with literal sameness of ...the case of abortion, those who die can, indeed, be seen as wronged twice over in being first deprived of their lives and then ...
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Association of <em>GEMIN4</em> gene polymorphism and the risk of cancer: a meta-analysis
... Relevant articles published prior to July 20, 2017 were mainly identified through searches of Web of Science, PubMed, Cochrane Library, Chinese Wan Fang, and Chinese National Knowledge Infrastructure databases online. ...
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Original Article Gene polymorphisms in the folate metabolic pathway and risk of pediatric acute lymphoblastic leukemia: a case-control study in a Chinese population
... ms in susceptibility to pediatric ALL in China. Both the cases and controls belonged to the same ethnic background and all shared a com- mon geographic origin in southern China. There were no associations between the ...
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Linked Data in the AEC : a case study on the application of Linked Data for Cost Control
... construction data was exported from the A1-A6 project environment in Relatics in order to filter and select a ...the data sample was imported into a Relatics environment, created for this ...financial ...
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Do We Need a Global Brain?
... Abstract: The new trend of Pervasive Computing, based on massively deployed wireless sensor and actuator networks, will enable gathering data about the world with an unprecedented accuracy, and using them to ...
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