Genetic Heterogeneity
Deep sequencing of hepatitis C virus hypervariable region 1 reveals no correlation between genetic heterogeneity and antiviral treatment outcome
... molecular genetic studies deep sequencing of HVR, calculated genetic heterogeneity parameters, performed the statistical analysis and drafted the ...calculated genetic heterogeneity ...
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Clinical and genetic heterogeneity of human cataract
... When applying positional cloning techniques, as in this project, it is critical to construct a complete list o f all possible genes that could be implicated in the disease o f interest. Such a list can be drawn up for ...
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Genetic heterogeneity in breast cancer: the road to personalized medicine?
... mendous genetic heterogeneity of cancers, their spatial dispersion and adaptation to myriad local microenviron- ments within the individual patient ...the genetic diversity within tumors which exists ...
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Clinical and genetic heterogeneity in Wilson disease - A review
... Seven recurring haplotypes were identified accounting for 58% of the different mutant chromosomes in WD in Indians [34]. Till date, a total of 51 mutations have been documented in India including 34 novel mutations ...
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Genetic heterogeneity in partial adenosine deaminase deficiency
... immunologically normal children from four different "families." These children lack ADA in their erythrocytes but retain variable amounts of activity in their lymphoid cells. We have examined ADA activity in ...
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Genetic heterogeneity and trans regulators of gene expression
... the genetic dissection of trans regulators remains a ...that genetic heterogeneity contributes to the difficulty of iden- tifying trans ...model genetic heterogene- ity may improve our ability ...
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Regulatory Rewiring in a Cross Causes Extensive Genetic Heterogeneity
... ABSTRACT Genetic heterogeneity occurs when individuals express similar phenotypes as a result of different underlying ...such heterogeneity is known to be a potential source of unexplained ...
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Genetic Heterogeneity in the rRNA Gene Locus of Trichophyton tonsurans
... about genetic variation, which may ultimately be linked to divergent disease ...identifying genetic variants of ...of genetic heterogeneity in ...
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Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies
... remarkable genetic heterogeneity of CC may be the result of a complex interplay among different causative factors, some shared by most human cancers while others typical of this ...the genetic ...
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Delineating the genetic heterogeneity of OCA in Hungarian patients
... molecular genetic investigation of all OCA genes is required to determine the subtype of the ...molecular genetic investigation identified the OCA1 subtype in eight cases, ...
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The clinical and genetic heterogeneity of autosomal dominant cataract
... In all the pedigrees apart firom the pulveru lent pedigrees the morphology was the same in all affected family members but varied in severity. In the pulverulent pedigrees the phenotype varied among affected individuals ...
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Resolving genetic heterogeneity in cancer.
... SciClone 37 and PhyloWGS 38 . Broadly, these tools attempt to identify sets of mutations that are all at the same frequency and assign them to clones. These tools have been instrumental to study cancer evolution from ...
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Genetic heterogeneity of motor neuropathies
... our genetic neuropathy clinic at Newcastle Hospitals NHS Foundation, which is the catchment area of a total population of ...confirmed genetic diagnosis were included in this cohort, even if no ...
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GENETIC HETEROGENEITY OF RABBIT ALPHA-1-ANTITRYPSIN
... We found interindividual differences in the electrophoretic A-1-AT patterns as well as quantitative differences in the concentrations of A-1-AT and the serum trypsin-inhibit[r] ...
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Genetic Heterogeneity and Recombination in Human Type 2 Astroviruses
... the genetic variability of HAstVs is important to understand if periodic genotype shifts and genetic or antigenic drifts occur and if these changes may fit a model of evolution analogous to those observed ...
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Genetic heterogeneity within individual bovine rotavirus isolates.
... BABIUK,* AND VIKRAM MISRA Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N OWO, Canada The genomic R[r] ...
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Genetic Heterogeneity and Recombination in Canine Noroviruses
... In conclusion, the findings of this study demonstrate that (i) NoVs circulate in dogs, (ii) that canine NoVs are genetically heterogeneous, (iii) that humans may be exposed to these newly recognized strains via certain ...
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Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype
... Since the frequency of HLA-C*06:02 was appreciably decreased in the PsA cohort compared with that in the PsO cohort, we then asked whether there are other HLA- B alleles that are significantly increased in the Irish PsA ...
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Evidence of intermetastatic heterogeneity for pathological response and genetic mutations within colorectal liver metastases following preoperative chemotherapy
... intermetastatic heterogeneity not only on a pathological but also genetic level within CLM in a given ...that genetic heterogeneity (one mutated CLM/one wild-type CLM) was observed in ...
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High Mutant Frequency in Populations of a DNA Virus Allows Evasion from Antibody Therapy in an Immunodeficient Host
... the heterogeneity of MVM populations are essentially un- ...high genetic heterogeneity in populations of a DNA ...This heterogeneity provides this DNA virus with a re- markable adaptability ...
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