Genetic risk score analysis (GRS)
Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders
... weak risk, remain to be ...in genetic influences on migraine and MDD, previously found in twin and family studies, at the measured genotype ...of genetic risk scores to investigate causality, ...
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Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants
... of genetic studies and GWAS have been conducted on European/Caucasian ...extend genetic studies to other ethnicities ...a genetic marker may not be associated with a trait in all ethnicities and in ...
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Traditional and Genetic Risk Score and Stroke Risk Prediction in Korea
... of risk alleles over all ...Stroke risk associated with any one genotype was estimated as an OR and 95% confidence interval (CI), and was computed using logistic regression under an additive genetic ...
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Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants
... GRS analysis could be masked by the relative stronger effect of other ...CAD risk, Jansen et ...of risk factors and non-risk factors-related SNP, reinforcing the genotype-phenotype ...
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Genetic risk score and risk of stage 3 chronic kidney disease
... Genotyping was performed with Affymetrix 500 K mapping array and the Affymetrix 50 K supplemen- tal array. Replicated quality control samples yielded high concordance (>99%), with the overall call rate >95%. All ...
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A genetic risk score is differentially associated with migraine with and without aura.
... rare genetic variants, which might especially play a role in ...tify genetic variants significantly associated with MWA, further studies characterized by larger sample size and powered enough to identify ...
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Genetic Risk Score Predicting Risk of Rheumatoid Arthritis Phenotypes and Age of Symptom Onset
... Study Sample Filtering Each confirmed RA case was matched to one healthy control by cohort (NHS or NHSII), year of birth, menopausal status, and post-menopausal hormone use. Our initial nested case-control dataset ...
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Additional value of a combined genetic risk score to standard cardiovascular stratification
... of genetic risk scores (GRS) as independent risk predictors remains ...Framingham risk score (FRS) in coronary artery disease (CAD) risk predic- ...32 genetic variants ...
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Statistical Methods in Genetic Association Studies and a Genetic Risk Score for Predictive Modeling of Disease Risk: from Gene Discovery to Translation.
... new genetic risk score method, EV- GRS, that performs very well overall compared to previously introduced methods, both in extreme and general ...
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Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis
... that genetic profiling could enhance the predictive accuracy of fracture prognosis based on the clinical data obtained from the Dubbo Osteoporosis Epidemiology Study as well as simulated genetic data of 50 ...
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Single-nucleotide polymorphism-based genetic risk score and patient age at prostate cancer diagnosis
... test (the trend test for groups with increasing risk). As PCa-free survival on an age scale is likely to be left-truncated owing to the fact that patients with a prior PCa diagnosis were not included in the REDUCE ...
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Genetic risk score of common genetic variants for impaired fasting glucose and newly diagnosed type 2 diabetes influences oxidative stress
... common genetic variants associated with increased fasting serum glucose are also associated with oxidative stress, such as increases in the urinary 8-epi-PGF 2α and plasma MDA ...of genetic varia- tion ...
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Influence of age on predictiveness of genetic risk score for prostate cancer in a Chinese hospital-based biopsy cohort
... Statistical methods Continuous variables were reported as median with interquartile range. Categorical variables were reported as counts with proportions. The association between continuous variables and binary outcomes ...
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Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population
... increased risk of belonging to a growth trajectory char- acterized by high BMI values across childhood and ado- ...be genetic factors that are specific to this age range: a recent study in 1229 Mexican ...
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Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
... Copyright: ß 2012 Derks et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, ...
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Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score
... of all eligible patients in the study area are recruited. Using frequency matching with respect to sex, age and county of residence, controls are randomly selected from population registries. Besides excluding persons ...
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How close are we to implementing a genetic risk score for coronary heart disease?
... 24 University Genome Sequencing Center.; Broad Institute.; Children's Hospital Oakland Research Institute., Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, ...
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Body mass index and depressive symptoms: instrumental-variables regression with genetic risk score
... the genetic risk score and study covariates were quantified as the proportional attenuation of the unadjusted regression coefficient compared to the adjusted ...the genetic risk ...
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Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease
... Seshadri, S., Fitzpatrick, A.L., Ikram, M.A., DeStefano, A.L., Gudnason, V., Boada, M., Bis, J.C., Smith, A.V., Carassquillo, M.M., Lambert, J.C., Harold, D., Schrijvers, E.M., Ramirez-Lorca, R., Debette, S., Longstreth, ...
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Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression
... with genetic susceptibility to produce the final affective/behavioral phenotype, ...dopamine genetic risk score measures interact with environmental factors in relation to depressive ...
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