genital herpes
Frequent genital herpes simplex virus 2 shedding in immunocompetent women Effect of acyclovir treatment
... that genital HSV-2 reactivation occurs much more commonly than previously ...of genital herpes and frequent reactivation by viral isolation; ( b ) occurred in clusters of days or episodes; ( c ) was ...
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Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir
... We then tested the effect of different durations of treat- ment (Table 4). A common inclusion criterion of the clinical studies that tested drugs against genital herpes is at least six genital ...
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Potent Adjuvant Activity of Cationic Liposome-DNA Complexes for Genital Herpes Vaccines
... for genital herpes have a long history, beginning in the 1940s, but only recently have some HSV-2 subunit vaccines shown partial efficacy in human trials (reviewed in reference ...primary genital ...
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Sacral Myeloradiculitis: An Uncommon Complication of Genital Herpes Infection
... with genital herpesvirus infections is often attributed to painful genital ulcerations, herpesvirus-associated lumbosacral myeloradiculitis has been reported in ...a genital herpes ...
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Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread
... on genital herpes, we took advantage of an HSV-2 variant, MS-luciferase, in which a luciferase expression cassette was inserted into the LAT locus (30), and monitored viral spread using bioluminescent ...
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A Protective Role of Locally Administered Immunostimulatory CpG Oligodeoxynucleotide in a Mouse Model of Genital Herpes Infection
... mucosal genital immune response that confers protective immunity against genital herpes ...the genital tract ...against genital herpes infection, ...a genital ...
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Antiviral Activity of Trappin-2 and Elafin In Vitro and In Vivo against Genital Herpes
... which may contribute to the pathogenesis and inflammation as- sociated with genital herpes (61, 62). Given that Tr/E were previ- ously shown to exert anti-inflammatory effects against bacterial (63, 64) and ...
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Progesterone Increases Susceptibility and Decreases Immune Responses to Genital Herpes Infection
... to genital tract ...to genital herpes simplex virus type 2 (HSV-2) after Depo-provera or a saline suspension of progesterone ...to genital HSV-2 compared to that of untreated ...
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Diagnosis of genital herpes simplex virus infection in the clinical laboratory
... tal herpes may be limited in ...of genital HSV infection from other infec- tious ( Treponemapallidum, Haemphilusducreyi ) and non- infectious etiologies of genital ulceration is often difficult and ...
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Effect of acyclovir treatment of primary genital herpes on the antibody response to herpes simplex virus
... primary genital herpes infections who were treated with the antiviral drug acyclovir were studied to determine the effect of therapy on the immune response to herpes simplex virus (HSV) glycoproteins ...
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Guidance on Management of Asymptomatic Neonates Born to Women With Active Genital Herpes Lesions
... but genital herpes infections in adults are very ...neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more ...primary ...
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GENITAL HERPES DISEASES: AN OVERVIEW
... Genital herpes is an acute inflammatory disease of the genitalia caused by herpes simplex virus ...Primary genital herpes is usually self-limiting but may cause painful local or ...
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Characterization of the IFN γ T cell responses to immediate early antigens in humans with genital herpes
... a protective response but rather the level of response needed for protection. As virus antigen declines following a recurrent episode the protective cellular response may also decline to below a threshold where the ...
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Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Recurrent Genital Herpes
... of herpes simplex virus 2 (HSV-2) from latency causes viral shedding that develops into recurrent genital ...recurrent genital herpes remain to be fully eluci- ...recurrent genital ...
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Detection of viral DNA to evaluate outcome of antiviral treatment of patients with recurrent genital herpes
... of genital herpes proven by ...of genital herpes at least every 4 months with a clearly identifiable ...the genital lesion occurred or only until day 5 if the lesion was ...
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Optimal management of genital herpes: current perspectives
... includes genital herpes, are treated with oral acyclovir, but during severe HSV infections, in particular among immunocompromised patients, the drug has to be used intravenously ...In genital ...
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Diversity of the CD8+ T-Cell Response to Herpes Simplex Virus Type 2 Proteins among Persons with Genital Herpes
... Cytolytic T cells play a major role in controlling herpes simplex virus type 2 (HSV-2) infections in humans. In an effort to more thoroughly evaluate the response to HSV-2 directly, ex vivo, we developed an ...
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Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV 2 DNA in cervicovaginal lavage fluids with cross sectional and longitudinal clinical data
... Four HIV-/HSV- women tested positive for HSV-2 DNA in CVL suggesting that they may have had pri- mary genital HSV-2 infection. Three of them had multi- ple lesion-episodes observed during the subsequent follow up. ...
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Virologic and Immunologic Evidence of Multifocal Genital Herpes Simplex Virus 2 Infection
... the genital tract was used to create a genital map that was divided into 22 sections for women and circumcised men and into 26 sections for uncircumcised ...After genital examination, Dacron swabs ...
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Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
... The black square shows that 50% of animals treated with GML in KYWJ became infected with a viral dose of 0.1 ID50, and the dashed arrow indicates that this treatment caused a 10-fold inc[r] ...
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