Genomic Stability
Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
... with genomic and chromosom- al packaging density, increasing genomic instability may be a result subsequent to drug-induced epigenetic modifica- ...on genomic stability in healthy human ...
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Revealing ETC-1922159 Affected Unknown 3rd Order Combinations of DNA Repair & Genomic Stability Factor RAD51 Family, in Silico
... order biological hypotheses emerge some of which are confirmed in wet lab, while others need to be tested. Keywords: WNT pathway; porcupine inhibitor ETC-1922159; sensitivity analysis; colorectal can- cer; unknown ...
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Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining
... of genomic abnormalities, which is less likely to trigger apoptosis in these cells and is therefore more likely to be tolerated, thus leading to a high rate of tumorigenesis in ...high genomic instability ...
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Pan genome analysis of ancient and modern Salmonella enterica demonstrates genomic stability of the invasive Para C lineage for millennia
... Our estimate of the timescale allowed us to investigate the rates of gain or loss events and pseudogene formation within Paratyphi C relative to the accumulation of SNPs (Figure S3). The results showed that pseudogenes ...
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Genomic Stability of Murine Leukemia Viruses Containing Insertions at the Env-3′ Untranslated Region Boundary
... GFP fluorescence serves as a reliable surrogate marker for genomic stability of the ZAPd-GFP virus over multiple infec- tion cycles. Based on the results of single-passage FACS anal- FIG. 3. ...
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The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability
... for genomic stability and ultimately for the survival of all organisms (Sancar et ...other genomic loci), and also that the protein machinery required for homologous recombination is functional in ...
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Genomic stability of gibbon oncornavirus.
... Since gibbon type C viruses examined for genomic homology by other investigators were found not to be identical, additional viruses isolated in our laboratory from leukemic and normal gi[r] ...
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Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica
... The maximum age of Paratyphi C is 3,169 y, the date when Paratyphi C split from its closest relatives, serovar Typhisuis. In turn, the estimated tMRCA for Paratyphi C, Typhisuis plus Choleraesuis was 3,943 y, and that ...
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Mycotoxin zearalenone exposure impairs genomic stability of swine follicular granulosa cells in vitro
... genome stability and inhibits growth of porcine granulosa cells via the estrogen receptors which may promote granulosa cell apoptosis when the DNA repair system is not enough to rescue this serious ...
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Genomic Stability of Palmer amaranth Plants Derived by Macro Vegetative Propagation
... The present study utilized qPCR and RAPD analysis to examine the genetic stability of successively cloned palmer amaranth plants. To determine the error within the qPCR method, duplicate assays were compared. Ge- ...
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Biochemical and Genetic Studies of Genomic Stability
... The accepted role of Dna2 in yeast DNA replication is to assist the major Okazaki fragment processing nuclease, Fen1, in removal of RNA/DNA primers on the lagging strand Budd et al., 200[r] ...
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Persistent Infection of Rhesus Macaques by the Rev-Independent Nef(−) Simian Immunodeficiency Virus SIVmac239: Replication Kinetics and Genomic Stability
... This observation was further corroborated by determina- tions of changes that occurred in the region spanning V1 and V2 (amino acids 90 to 200 of Env) (4, 15) of the Rev-indepen- dent Nef(2) virus. Genomic DNA ...
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The Role of Cdh1p in Maintaining Genomic Stability in Budding Yeast
... much healthier than a pds1⌬ cdh1⌬ strain (Figure 5). (1997) showed that overexpression of nondegradable This is in agreement with Lengronne and Schwob Ase1p when combined with a mad1⌬ mutation resulted (2002), who found ...
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Contributions of DNA2 and the Tim/Tipin Complex to Genomic Stability
... Tipin is the target of ATR, the checkpoint kinase activated by incomplete DNA replication and stalled replication forks, and not ATM, the checkpoint kinase activated by DNA double-stra[r] ...
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Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics
... Results: BIN-67 cells were capable of forming spheroids in hanging drop cultures. When xenografted into immunodeficient mice, BIN-67 cells developed into tumours that reflected the hypercalcemia and histology of human ...
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Genetic and genomic stability across lymphoblastoid cell line expansions
... In total, we identified 22 unique CNV regions across all 129 samples (Additional file 3: Table S2); however, 3 of these were immunoglobulin (IG) regions that have been previously implicated in cell culture artifacts ...
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Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stability
... genetic stability. However, the pathways for maintaining the genetic stability of ESCs and somatic cells are not completely conserved ...maintaining genomic stability by phosphorylating and ...
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CTCF Regulates Kaposi's Sarcoma-Associated Herpesvirus Latency Transcription by Nucleosome Displacement and RNA Polymerase Programming
... We analyzed the genomic stability, transcription profiles, histone modifications, nucleosome organization, and RNAPII processing for latency transcripts of the KSHV genome with wild-type[r] ...
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The Dimensionality of Genomic Information and Its Effect on Genomic Prediction
... of 10 nonoverlapping generations, with 25,000 animals per generation and phenotypes available for generations 1 – 9. The last 3 generations were fully genotyped assuming genome length L = 30. The GRM was constructed for ...
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Genomic and post-genomic analyses of human prion diseases
... markers (ApoE [50], F2-isoprostanes [48,49], uric acid [50]; Table 1), which might reflect different molecular processes in these diseases. This observation is in line with what was observed in the recent genomic ...
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