Genotoxic stress
p53 dependent ceramide response to genotoxic stress
... Both p53 and ceramide have been implicated in the regula- tion of growth suppression. p53 has been proposed as the “guardian of the genome” and ceramide has been suggested as a “tumor suppressor lipid.” Both molecules ...
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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
... Genotoxic stress can inhibit mTOR signaling through activa- tion of p53 (Feng et al., 2005). To study the role of Sestrins in this response in vivo, we generated Sesn2 knockout mice using gene trap ES cells ...
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Genotoxic Stress and Cellular Stress Alter the Subcellular Distribution of Human T-Cell Leukemia Virus Type 1 Tax through a CRM1-Dependent Mechanism
... of genotoxic stress on the subcellular distribution and interacting partners of ...cellular stress, resulting in an increase in cytoplasmic Tax and a decrease in Tax speckled ...
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Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3
... PP2C family serine/threonine phosphatase WIP1 acts as a negative regulator of the tumor suppressor p53 and is implicated in silencing of cellular responses to genotoxic stress. Chromosomal locus 17q23 ...
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TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress
... RS-like stress hypersensitivity to otherwise harmless chemotherapeutic doses, although manifestations involving neuronal functions, epilepsy in particular, may require continuous management using an independent ...
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KMT Set7/9 affects genotoxic stress response via the Mdm2 axis
... Genotoxic stress inflicted by anti-cancer drugs causes DNA breaks and genome instability. DNA double strand breaks induced by irradiation or pharmacological inhibition of Topoisomerase II activate ATM ...
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Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9
... Alternative splicing plays a key role in the DNA damage response and in cancer. Ewing Sarcomas (ES) are aggressive tumors caused by different chromosomal translocations that yield in-frame fusion proteins driving ...
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Logical network of genotoxic stress-induced NF-kappaB signal transduction predicts putative target structures for therapeutic intervention strategies
... Abstract: Genotoxic stress is induced by a broad range of DNA-damaging agents and could lead to a variety of human diseases including ...by genotoxic stress in epithelial ...
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Xanthine oxidoreductase is required for genotoxic stress- induced NKG2D ligand expression and gemcitabine-mediated antitumor activity
... are stress-inducible ligands for the immune-receptor ...which genotoxic stress and DNA damage induce the expression of NKG2D ligands remain incompletely ...abrogated genotoxic ...
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The yeast mitogen-activated protein kinase Slt2 is involved in the cellular response to genotoxic stress
... to genotoxic stress since cell cycle arrest occurs in the absence of ...to genotoxic stress could be related with its known function in cell morphogenesis, the actin cytoskeleton and cell ...
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The conservation of genotoxic stress-induced morphological changes in yeasts
... that genotoxic stress-induced filamentous growth is not or is only partially mediated by Swe1, unlike the Rad53-Swe1-dependent process observed in ...abolish genotoxic stress-induced ...
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UV and genotoxic stress induce ATR relocalization in mouse spermatocytes
... by genotoxic stress can activate ATR and influence meiotic chromatin remodelling through H2AX phosphorylation, likely as part of a response which normally ensures germ cell genomic ...
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The SOS and RpoS Regulons Contribute to Bacterial Cell Robustness to Genotoxic Stress by Synergistically Regulating DNA Polymerase Pol II
... We observed that genotoxic stress, caused by MMC, acti- vated the RpoS regulon in growing cells. Consequently, we tested the involvement of the two-component system BarA- UvrY, which is known to be involved ...
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Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo
... extrinsic stress, consistent with recent observations in the developing kidney ...culture-associated stress may have constituted an activating stimulus in those ...external stress stimuli: this may ...
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Il-10 Family Members as Novel Responders to Genotoxic Stress
... IL-19 expression and secretion is associated with a variety of inflammatory disorders in humans, including rheumatoid arthritis, inflammatory bowel disease, and psoriasis 144 . For example, IL-19 mRNA levels are ...
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Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis
... Several stem cell lineages (including neural and hematopoietic stem cells) show a stage-specific suscepti- bility to genotoxic stress, which may be related to cell- intrinsic changes or changes in the ...
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The RNA helicase A in malignant transformation
... to genotoxic stress, but not non-sarcoma cancer cells [89, 19], indicating that the underlying mechanism involves RHA/EWS-FLI1 interaction and confirming that the activity of RHA is dependent on its ...
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Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB
... MDMX is a protein paralogous to the MDM2, they share a high similarity in their RING domains. However MDMX does not have detectable E3 ubiquitin ligase activity [46-48]. The MDMX and p53 interaction has also been very ...
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Scorpins in the DNA Damage Response
... SPRY-COntaining RAN binding Proteins (Scorpins) RANBP9 and RANBP10 are evolutionarily conserved and ubiquitously expressed proteins whose biological functions are still debated. RANBP9 has been previously implicated in ...
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Radioprotection: smart games with death
... to genotoxic stress has led to the development of new rational approaches to selective protection of normal cells, such as suppression of apoptosis by pharmacological inhibition of p53 or activation of ...
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