Germinal center B cell
Original Article The phenotypes of germinal center B-cell-like (GCB) and non-GCB failed to predict the survival of patients with diffuse large B-cell lymphoma in the rituximab era
... large B-cell lymphoma (DLBCL), ac- counting for approximately 30% to 40% of all non-Hodgkin lymphoma (NHL) cases [1], is a clinically and biologically heterogeneous [2] ne- ...DLBCL, germinal ...
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Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma
... to cell-of- origin gene signatures: germinal center B-cell-like (GCB), arising from the germinal center (GC) compartment, and activated B-cell-like (ABC), ...
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Neutrophils trigger a NF-κB dependent polarization of tumor- supportive stromal cells in germinal center B-cell lymphomas
... large B-cell lymphomas (DLBCL) are two germinal center-derived lymphomas where various cell components of infiltrating microenvironment, including TAN and CAFs, have been demonstrated ...
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Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation
... infected B cells in germinal center (GC) reactions to expand latency and to gain access to memory B cells, the major reservoir of gammaherpesvi- rus latency ...GC B cells is mediated by ...
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Different sensitivity of germinal center B cell-like diffuse large B cell lymphoma cells towards ibrutinib treatment
... large B cell lymphoma (DLBCL), the most com- mon subtype of non-Hodgkin lymphoma (NHL) with ag- gressive property could be divided into three subgroups based on gene expression profile: germinal ...
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Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development
... GC B cells did not significantly reduce NP-specific IgG1 serum levels or the number of NP-specific IgG1 antibody-secreting cells (ASCs) in the spleen and bone marrow ...
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Common Germinal-Center B-Cell Origin of the Malignant Cells in Two Composite Lymphomas, Involving Classical Hodgkin’s Disease and Either Follicular Lymphoma or B-CLL
... the B-CLL type (Fig. 1). Admixt with the B-CLL were small islands of classic HD containing typical HRS cells in a histiocyte- and lymphocyte-rich back- ground ...The B-CLL cells were negative for ...
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αv Integrins regulate germinal center B cell responses through noncanonical autophagy
... of B cell TLRs in promoting effective immunity is increasingly appreciated, the factors that affect TLR signaling in these cells and how these affect immune responses remain poorly ...GC B cells ...
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MYC chromosomal aberration in differential diagnosis between Burkitt and other aggressive lymphomas
... aggressive B-cell lymphomas, and identified a consistent gene panel characteristic of molecular ...activated B-cell-like (ABC) or germinal-center B-cell-like ...
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www.ijcep.com /IJCEP1002005 Case Report An uncommon case of de novo CD10 CD5 mantle cell lymphoma mimics follicle center B cell lymphoma
... Because of the differences in treatment strat- egy and clinical outcome, it is important to dis- tinguish MCL from germinal center B-cell- derived lymphomas. In most cases, this distinc- tion ...
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Vitreoretinal lymphoma followed by systemic diffuse large B cell lymphoma
... Intraocular lymphoma is diagnosed histologically with immunohistochemistry, flow cytometry, and PCR ana- lysis [2]. Typically, intraocular lymphoma is of the non- germinal center B cell, or ...
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Treatment outcome and prognostic factors in PCNSL
... Methods: We conducted a retrospective study of 43 patients diagnosed with PCNSL, DLBCL subtype, who were treated with either HDMTX-based regimen, whole brain radiotherapy (WBRT), or both between 2010 and 2017. Results: ...
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Expansion of HIV specific T follicular helper cells in chronic HIV infection
... the B cell compartment. These changes in the B cell subset are most prominently seen as an expansion of germinal center B cells and plasma ...the germinal ...
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A large single-institution retrospective analysis of aggressive B-cell lymphomas according to the 2016/2017 WHO classification
... aggressive B-cell ...grade B-cell lymphoma with blastoid morphology”); 2) im- munophenotype along with Ki67 proliferation index; 3) COO: germinal center B-cell ...
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Extranodal diffuse large B-cell lymphoma with monoclonal gammopathy: an aggressive and primary refractory disease responding to an immunomodulatory agent
... rituximab, cyclophosphamide, vincristine, doxorubicin and prednisone (R-CHOP) [6]. Another clinical parame- ter reflecting the heterogeneity of this disease is the pres- ence of monoclonal gammopathy (MG) in some ...
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Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses
... of germinal center ...) B-cell rich lymphoid follicles with rare germinal centers ...with germinal centers (average, ...with germinal centers (average, ...
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Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity
... DSBs, B lymphocytes harbor general DSBs arising from genotoxic agents such as oxidative damage or DNA replication ...peripheral B cells reduces the CSR level and causes a high level of chromosomal breaks ...
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Profiling of Hodgkin’s Lymphoma Cell Line L1236 and Germinal Center B Cells: Identification of Hodgkin’s Lymphoma-specific Genes
... hematopoietic cell type because coexpression of markers known for distinct hematopoietic lineages is often observed ...typical B cell markers (1,5,7), molecular studies have shown that they derive ...
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Rastelli, Julia (2007): Latent Epstein-Barr virus infection and the germinal center reaction. Dissertation, LMU München: Fakultät für Biologie
... memory B cells carrying somatic mutations in their Ig ...infected B cells gain a surface marker expression reminiscent of memory B cells as soon as EBNA2 is ...memory B cell ...infected ...
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Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications
... diagnose B-cell non-Hodgkin lymphomas, since these comprise the majority of non-Hodgkin ...differentiate B cells from T cells. CD20 and CD19 served as B-cell specific markers; CD3 and ...
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