germinal center (GC)
EBNA2 Interferes with the Germinal Center Phenotype by Downregulating BCL6 and TCL1 in Non-Hodgkin's Lymphoma Cells
... Among non-Hodgkin’s lymphomas (NHLs), the noted asso- ciation of Epstein-Barr virus (EBV) is with endemic Burkitt lymphomas (BLs). Diffuse large B-cell lymphomas (DLBCLs) are a heterogeneous group of tumors, about 10% of ...
9
Rastelli, Julia (2007): Latent Epstein-Barr virus infection and the germinal center reaction. Dissertation, LMU München: Fakultät für Biologie
... the germinal center to get access to the memory B cell compartment (Thorley-Lawson, 2001; Thorley-Lawson and Babcock, ...the germinal center without negative selection, and allow the ...
105
Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas
... Follicular lymphoma (FL) is the commonest form of indolent B-cell lymphomas and the second most fre- quent type of non-Hodgkin ’ s lymphoma (NHL) in wes- tern countries [1]. Biologically, FL represents the neoplastic ...
7
The Intersection of Epstein-Barr Virus with the Germinal Center
... B cell remains controversial. The most widely held model is that the virus uses the growth latency program to drive newly infected resting B cells into the cell cycle so that they can differentiate into the resting ...
9
Asymmetric B Cell Division in the Germinal Center Reaction
... Antibody responses are one of the major defense mechanisms that mammals employ against microbial infections. As such, these responses have been targeted by most vaccine regimens used to prevent infections. However, in ...
110
Germinal center reentries of BCL2 overexpressing B cells drive follicular lymphoma progression
... This property of GC reentry and memory B cell response dynamics has provided new perspectives on the understanding of the early steps governing B cell lymphomagenesis, in particular those originating from GC B cells (5). ...
16
Germinal center architecture disturbance during Plasmodium berghei ANKA infection in CBA mice
... ganized germinal center with intense centroblast (Ct) activa- tion and proliferation and apoptosis (white arrows), without centrocyte ...Disorganized germinal center (Gc), without definition ...
8
Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase
... Germinal center kinase-like kinase (GLK) is a key controller of autoimmunity. In this study, we assessed the clinical relevance and tumorigenic effects of GLK in hepatocellular carcinoma (HCC). Using ...
12
Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome
... Ectopic germinal center; eGFR: Estimated glomerular filtration rate; ESR: Erythrocyte sedimentation rate; ESSDAI: Eular Sjogren ’ s Syndrome Disease Activity Index; FFPE: Formalin-fixed and ...
11
Lethal Coinfection of Influenza Virus and Streptococcus pneumoniae Lowers Antibody Response to Influenza Virus in Lung and Reduces Numbers of Germinal Center B Cells, T Follicular Helper Cells, and Plasma Cells in Mediastinal Lymph Node
... This study showed that lethal coinfection reduced virus-spe- cific IgG, IgM, and IgA in the lung. To delineate the reason for the local reduction of antibody, we investigated the mechanism at the cellular level by ...
11
Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker
... GLK: germinal center kinase-like kinase; HC: healthy control; IL: interleukin; IQ: interquartile; JNK: c-Jun N-terminal kinase; MAPKs: mitogen-activated protein kinases; NF: nuclear factor; PBMCs: ...
10
Early T Follicular Helper Cell Responses and Germinal Center Reactions Are Associated with Viremia Control in Immunized Rhesus Macaques
... 61. Havenar-Daughton C, Carnathan DG, Torrents de la Pena A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, Mohammed AUR, Huang J, Gumber ...
22
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses
... (Plasmodium yoelii 17XNL) to assess the contribution of the pattern recognition receptor cyclic GMP-AMP synthase (cGAS) to the development of humoral immunity. Despite previous reports suggesting a critical, intrinsic ...
19
Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus
... the germinal center B cell pop- ulation in naive IRF-1 ⫺/⫺ mouse ...modest germinal center phenotypes observed in naive animals are likely due to low levels of constitutive IRF-1 ...
12
Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development
... To determine the extent to which the deletion of relb and nfkb2 in GC B cells affects ICOSL expression on GC B cells in vivo, we stained splenic mononuclear cells from relbfl/flnfkb2fl/f[r] ...
24
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
... Protection against deadly pathogens requires the production of high-affinity antibodies by B cells, which are generated in germinal centers (GCs). Alteration of the GC developmental program is common in many B ...
15
Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus
... Consistent with this model and in keeping with their absence from the GC compartment, while the frequency of healthy 9G4 B cells among tonsillar total CD27+ memory B cells 1.8% ± 0.7% wa[r] ...
13
αv Integrins regulate germinal center B cell responses through noncanonical autophagy
... Strong B cell responses are a central component of effective long-lasting immunity to pathogens. B cells possess the unique ability to adapt the sequence of their immune receptors during the course of infection, allowing ...
17
Cellular Basis of Antibody Maintenance: Heterogeneity of the Bone Marrow Plasma Cell Pool
... While there is limited evidence that B cells can get activated in the bone marrow (Benner and Van Oudenaren, 1975; Cariappa et al., 2005), conventional models conceive of B cell activation as taking place in the ...
131
The concordance of minor salivary gland histology with the clinical parameters in patients with a provisional diagnosis of Sjogren's syndrome
... ABBREVIATIONS AD: Acinar Degeneration AT: Adipose Tissue DE: Ductal Ectasia DP: Ductal Proliferation FI: Focal Inflammation GC: Germinal Center IF: Interstitial Fibrosis KCS: Keratoconju[r] ...
88