GIANT CELL TUMOR OF BONE: ANALYSIS OF 208 CASES IN
Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis
... meta- analysis confirmed the effect of BPs on local recurrence of GCTB but did not conclude that BPs can substitute the role of ...with tumor responses and reduced the need for morbid surgery in patients ...
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Retrospective analysis of 51 intralesionally treated cases with progressed giant cell tumor of the bone: local adjuvant use of hydrogen peroxide reduces the risk for tumor recurrence
... advanced cases in our university institution, specialized in orthopedic on- cology, as well as by the cases initially treated in other surrounding hospitals and referred to us for further follow-up due to ...
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Denosumab treatment of inoperable or locally advanced giant cell tumor of bone - Multicenter analysis outside clinical trial
... account, that all these tumors were very advanced locally with large soft tissue mass, penetration into the joint and/or with pathological fracture. Of course none of these features is per se an indication for denosumab ...
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Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab
... 2. Case Reports 2.1. Case 1. A 46-year-old male presented in 2002 to an outside institution with five to six years of right hip pain radiating down the lateral thigh. Initial imaging is unavailable but by report ...
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Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
... radiological analysis at the primary hospital, he was referred to our ...cortical bone located just to the outer side of the tibial ...cortical bone in the epiphysis of the left prox- imal tibia ...
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Role of cancer stem cells in the development of giant cell tumor of bone
... of tumor cells of the GCT has also been confirmed by non-sub- stantial increase in the progress of GCTSC proliferation ...[131]. Analysis of CD166 and CD105 mRNA were also analyzed in which it was found ...
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Giant cell tumor of tendon sheath in the hand: analysis of risk factors for recurrence in 50 cases
... the tumor may penetrate into joints and bone cortices, extend into tendon sheaths and enclose neurovascular structures, establishing the correct balance between a complete and aggressive tumor ...
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Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experience
... 48 giant cell-containing tumors and pseudotumors of ...Data analysis was performed using Epi-info software and SPSS software package (version ...Immunohistochemical analysis showed a P63 ...
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Expression of ezrin, CD44, and VEGF in giant cell tumor of bone and its significance
... regulating cell adhesion ...of tumor cells, regulate cell-cell adhesion with extracellular matrix, and promote metastasis and proliferation of ...survival analysis showed that CD44 ...
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Risks and benefits of combining denosumab and surgery in giant cell tumor of bone-a case series
... of giant cell tumor of bone, but the available data in the literature remains sparse and ...for giant cell tumor of bone between 2010 and 2014 in an institution, ...
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MicroRNA-106b inhibits osteoclastogenesis and osteolysis by targeting RANKL in giant cell tumor of bone
... the analysis, knowing that these conditions may affect bone ...used bone- modifyingagents such as zoledronic acidbefore surgery were also ...from tumor samples derived from tumor ...
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Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone
... of tumor response in bone tu- mors presents unique challenges, and no uniform radiographic assessment criteria to date have been ad- vanced to specifically assess response in ...our analysis combined ...
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Risks and benefits of combining denosumab and surgery in giant cell tumor of bone—a case series
... large tumor extension necessitating a resection of the involved bone or ...six cases, the surgical indication was not changed despite the denosumab treatment, and two of them needed a joint ...
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Incidence and demographics of giant cell tumor of bone in The Netherlands: First nationwide Pathology Registry Study
... Chawla S, Henshaw R, Seeger L, Choy E, Blay JY, Ferrari S, Kroep J, Grimer R, Reichardt P, Rutkowski P, Schuetze S, Skubitz K, Staddon A, Thomas D, Qian Y, Jacobs I. Safety and efficacy of denosumab for adults and skel- ...
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Heat Shock Protein 70 Expression in Giant Cell Tumor of Bone and Its Clinical Application
... of giant cell tumor of bone which is a common benign aggressive bone tumor by the use of thermoablation, Hsp70 expression of the tumor was explored and the relationship ...
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Original Article Diffuse tenosynovial giant cell tumor in the temporomandibular joint area in a Chinese population: a clinicopathological analysis of 32 cases
... 32 cases of D-TGCT in the temporo- mandibular joint area diagnosed in the Department of Oral Pathology from 2000 to 2013 were ...the tumor cells, cartilaginous metaplasia, bone tissue invasion, ...
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Original Article Inhibition of curcumin on proliferation and invasion in giant cell tumor of bone (GCTB) by targeting STAT3
... GCTB tumor tissues collection Human GCTB tissue and normal cancellous bone without bone marrow cells were collected from 4 patients with GCTB after resection in Department of Orthopaedics in Nan Fang ...
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Factors Influencing the Recurrence of a Giant Cell Tumor of the Bone
... two cases who were diagnosed with a giant cell tumor of the bone between March 1992 and March 2001 and were could be followed up for at least 2 years were analysed ...gender, ...
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Giant-cell tumor of bone: treatment options and role of denosumab
... The discovery of the important role of RANKL in GCTB has been the key to understanding the pathophysiology of this disease. RANKL was originally identified from a murine thymoma line in studies done to elucidate TNFR ...
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Giant cell tumor of bone and tenosynovial tissue : surgical outcome
... 3 In the present study, the functional outcome as assessed with the MSTS score was excellent for all adjuvants and reconstruction methods. However, even though joint salvage was achieved in all patients, different cavity ...
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