GIANT CELL TUMOUR OF BONE : ARE WE STRATIFYING
A three-dimensional printed porous implant combined with bone grafting following curettage of a subchondral giant cell tumour of the proximal tibia: a case report
... great bone conduction and induction provided by autograft/allograft would ensure a low incidence of postoperative degenera- tive changes and mechanical ...non-biological bone-cement interface have still not ...
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Pathologic fracture of a giant cell tumour of the patella
... multinucleated giant cells in a background of mononuclear stromal cells arranged in syncytial ...multinucleated giant cells were observed to be ...with giant cell tumour (GCT) of ...the ...
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Giant-cell tumor of bone: treatment options and role of denosumab
... aneurysmal bone cysts, fibrous dysplasia, telangiectatic osteosarcoma, Langerhans cell histiocytosis, and other rare ...new bone formation should bring up the pos- sibility of osteosarcoma, which can ...
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Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone
... Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or ...
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Giant Cell Tumour of Extensor Tendon Sheath in the Hand–A Case Report and Strategies to Prevent Recurrence
... which showed similar signal intensity to the adjacent muscles and heterogenous enhancement in post Gadolinium as shown in Fig. 2. The lesion abuts the adjacent periosteum but no reaction or erosion noted. It has closed ...
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Quality of life in patients with bone tumour
... with bone metastases assess their health significantly worse than other ...having giant cell ...with bone metastases, and these data are also consistent with the results of studying health ...
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Giant cell tumour of the distal radius/ulna: response to pre-operative treatment with short-term denosumab
... subarticular bone by 2 months; internal matrix sclerosis and osseous consolidation was more ...Increased tumour heterogeneity and low signal were observed on T2-weighted MR ...avoiding bone resection ...
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Giant Cell Tumour of the Skull Base Treated with Surgery, Stereotactic Radiosurgery and Denosumab: Case Report and Review of Literature
... petrous bone, followed by endoscopic transnasal trans sphenoidal ...a tumour composed of multinucleated giant cells in a prolifera- tive spindle cell ...Stromal cell showed occasional ...
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Human giant cell tumors of bone identification and characterization of cell types
... Human giant cell tumors of bone are most likely a neoplasm of connective tissue stromal cells, which have the capacity to recruit and interact with multinucleated giant cells that exhibit ...
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Giant cell tumor of bone and tenosynovial tissue : surgical outcome
... 3 In the present study, the functional outcome as assessed with the MSTS score was excellent for all adjuvants and reconstruction methods. However, even though joint salvage was achieved in all patients, different cavity ...
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Cervical spine giant cell bone tumor: a case report
... Abstract Background: Giant cell tumors (GCTs) of the bone are locally aggressive primary bone tumors with a benign character. Spinal involvement is rare and they are quite rare in the cervical ...
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Review Article Giant Cell Tumor of Bone: A Neoplasm or a Reactive Condition?
... Abstract: Giant cell tumor of bone (GCTB) is a benign but locally aggressive bone tumor of young ...multinucleated giant cells and spindly stromal cells are ...While giant cells ...
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Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
... conclusion, we have reported a case of GCTB of the tibia with skip bone metastases to the ipsilateral femur, successfully treated with denosumab administration fol- lowed by surgical ...tumor, we ...
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Role of cancer stem cells in the development of giant cell tumor of bone
... the giant cell tumor of bone in general and how cancer stem cells play a vital role in the development of GCTB which is highly important in research aspects ...nowadays. Bone tumor is ...
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Local control of giant cell tumors of the long bone after aggressive curettage with and without bone cement
... with bone grafting, bone cement can be combined with firmly scraping the edges of the residual ...When bone cement solidi- fies, it releases polymerizing heat reaching 80-90°C, which has a ...
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Gene transfection in primary stem-like cells of giant cell tumor of bone
... stromal cell of GCT represents the target for antineoplastic drug devel- opment, although the nonproliferating osteoclast has been targeted with human monoclonal antibodies to RANKL, with guarded ...stromal ...
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Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab
... The other case arose during the study. The investigators did not believe in a connection between denosumab and sarcomatous transformation of GCT. Interestingly, a case of thyroid carcinoma with high grade sarcoma was ...
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Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis
... Background Giant cell tumor of bone (GCTB) is a common and locally aggressive bone tumor in East and Southeast Asian patients, which usually involves the end of long bones and comprises ...
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Safety and efficacy of denosumab in the treatment of pulmonary metastatic giant cell tumor of bone
... denosumab, giant cell tumor of bone, pulmonary metastasis, RANKL, recurrence Introduction Giant cell tumor (GCT) of bone is an intermittent tumor that is responsible for ~ 6% of ...
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Clinical characteristics and prognoses of six patients with multicentric giant cell tumor of the bone
... but we were able to determine whether the MGCT was a metastatic disease based on reoccurrence ...limitations, we believe that our results provide useful information for more accurate recognition of ...
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