Ginsenoside Rb1
Ginseng extract and ginsenoside Rb1 attenuate carbon tetrachloride induced liver fibrosis in rats
... and Rb1. Red ginseng saponin, containing ginsenosides Rb1, Rb2, Rc, Rd, Re and Rg1, played a crucial role in hepatoprotection by suppressing oxidative stress and lipid peroxides via inhibiting the ...
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Promoting Effect of Ginsenoside Rb1 for GLUT-4 Gene Expression and Cellular Synthesis in C2Cl2 Muscle Cells
... of ginsenoside Rb1 on the gene expression of GLUT-4 has not been reported so ...of Rb1 on the GLUT-4 gene expression level we incubated the differentiated C2C12 myotubes with different concentrations ...
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Null effect of ginsenoside Rb1 on improving glycemic status in men during a resistance training recovery
... containing ginsenoside Rb1 (or a placebo solution) for 5 consecutive ...days. Rb1 and Placebo drinks were made available by 0900 am in the ...The Rb1, provided by NuLiv Science (Walnut, CA, ...
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Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
... Cultured rat PMVECs were randomly divided into two groups: Control group and LPS group. Cells in Control group were received vehicle (0.01% DMSO) only. In LPS group the cells were stimulated with 1000 ng/ml LPS ...
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<p>Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress</p>
... Ginsenoside Rb1 was purchased from Shanghai Tauto Biotech Co (purity >98%, Shanghai, China). Anti-BDNF antibody (rabbit monoclonal to BDNF, clone ID: EPR1292) was purchased from Epitomics Co. (Epitomics, ...
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Improved conversion of ginsenoside Rb1 to compound K by semi-rational design of Sulfolobus solfataricus β-glycosidase
... from ginsenoside Rb 1 to compound K via Rd and F 2 is the most important because Rb 1 is the most abundant component in ginseng ...of ginsenoside Rd to F 2 is a limiting step in the hydrolytic pathway ...
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Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria
... judged by the times required to reach the maximum level of Cpd K when Rd and G-XVII were separately incubated with human gut bacteria. These findings suggested that the removal of the remote glucose molecule at the C-20 ...
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Effects of ginsenoside Rb1 on spinal cord ischemia-reperfusion injury in rats
... Fig. 3 The expression of survivin in spinal cord tissue. Survivin staining of spinal sections from different groups. c GRb1 treatment groups 10 mg/kg. d GRb1 treatment groups 20 mg/kg. e[r] ...
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Neuroprotective effect of panax notoginseng saponins and its main components
... PNS. Rb1 can decrease the degree of cerebral edema, improve neuro- behavioral score, protect vascular system from thicken- ing and spasm [17], inhibit lipid peroxidation in the brain [18], improve the symptoms of ...
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Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer
... of ginsenoside and a chemotherapy agent represents an optimal choice that could result in enhanced therapeutic efficacy and reduced off-target ...used ginsenoside as a multifunctional membrane material to ...
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Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma
... RNA extraction, reverse transcription, and quantitative real-time PCR. Total RNA was isolated from peripheral retinas (α-Cre expression area) using TRIzol reagent (Invitrogen, Thermo Fisher Scientific) or RNeasy Mini Kit ...
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Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma
... (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal ...
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Comparing Ginsenoside Production in Leaves and Roots of Wild American Ginseng (Panax quinquefolius)
... There have been reports of American ginseng chemo- types in North America populations that differ in the ratio of Rg1:Re. Universally low Rg1:Re chemotypes were reported for wild and cultivated plants from the northern ...
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Alteration in Methylation Pattern of Retinoblastoma 1 Gene Promotor Region in Intestinal Metaplasia with or without Helicobacter pylori and Gastric Cancer Patients
... about RB1 gene methylation in GC. Thus, the role of RB1 in GC has not been fully under- stood and needs further ...of RB1 gene in GC and IM with or without ...ined RB1 gene methylation status ...
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Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development
... Using various mouse models, we have previously defined key roles for the Retinoblastoma family in epidermal homeostasis, proliferation, differentiation and tumor development (reviewed in Costa et al [6]). We described ...
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CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways
... and Rb1 can be inactivated by hyperphosphorylation [33, 34], and phosphorylated Foxo1 is exported from the nucleus in a CRM1- dependent ...and Rb1 in gli- oma ...phosphorylated Rb1 in a ...
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Complete conversion of all typical glycosylated protopanaxatriol ginsenosides to aglycon protopanaxatriol by combined bacterial β-glycosidases
... Re and Rg2 and the outer arabinopyranose residue at C-20 in ginsenoside F3 and showed low activity for the outer xylose residue at C-6 in ginsenoside R2 (Fig. 1). In contrast, PF-bgl hydrolyzed the outer ...
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Enhancement of neuroprotective activity of Sagunja tang by fermentation with lactobacillus strains
... (liquiritigenin), 36.55 (glycyrrhizin), 44.71 (atractylenolide III), 52.64 (atractylenolide II), and 57.11 (atractylenolide Ι) in SGT166. Pachymic acid as a standard compound of poria sclerotium was not detected in our ...
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Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats.
... with ginsenoside Rg1, the levels of IL-1, IL-6, and TNF-a decreased remarkably in a dose- and time-dependent ...processes. Ginsenoside Rg1 potently inhibited JNK activity as indicated by the p-JNK level in ...
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Immune response to RB1 regulated senescence limits radiation induced osteosarcoma formation
... induced RB1-dependent senescence and the expression of a panel of proteins known as senescence-associated secretory phenotype (SASP), dominated by ...IL-6. RB1 expression closely correlated with that of the ...
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