Ginsenoside Rg3 (GRg3)
Clinical benefit from EGFR-TKI plus ginsenoside Rg3 in patients with advanced non-small cell lung cancer harboring EGFR active mutation
... that ginsenoside Rg3, an active ingredient extracted from ginseng leachate, exhibits an anti-cancer effect through suppressing angiogenesis in various tumors ...[11]. Ginsenoside Rg3 ...
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Ginsenoside Rg3 attenuates hepatoma VEGF overexpression after hepatic artery embolization in an orthotopic transplantation hepatocellular carcinoma rat model
... that ginsenoside Rg3 combined with conventional TAE treatment may effectively limit HCC tumor progression, reduce metasta- sis, and increase overall ...survival. Ginsenoside Rg3 combined with ...
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<p>Intake consumption of ginsenoside Rg3, profiling of selected cytokines, and development of rectal polyps</p>
... Ginsenoside Rg3, the major active component of gin- seng, has been shown to have various therapeutic effects including anti-in fl ammatory and anti-tumorigenic activity, however, its relationship with level ...
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20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
... 20(S)-ginsenoside Rg3 (20(S)- Rg3) is a steroidal saponin with high pharmacological ...20(S)-ginsenoside Rg3, senescence, apoptosis, p53 ...
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Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction
... whether ginsenoside Rg3, an active ingredient of the herbal medicine ginseng that is used as a tonic and restorative agent, could attenuate prion peptide, PrP (106-126)-induced neurotoxicity and ...
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Original Article Effects of ginsenoside Rg3 combined with 125 I seeds on serum TGF-α, TGF-β1, and VEGF in patients with medium and advanced non-small cell lung cancer
... on serum transforming growth factor-α (TGF-α), TGF-β1, and vascular endothelial growth factor (VEGF) in patients with medium and advanced non-small cell lung cancer (NSCLC). Methods: A total of 62 patients with medium ...
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Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro
... ginseng, ginsenoside Rg3 (RG3) is the protopanaxadiol type of dammarane ginsenoside consisting of characteristic genuine aglycone moieties ...[20]. RG3 has multiple functions in immune ...
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<p>Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a</p>
... 10,11 Ginsenoside Rg3 is the most active compound of ...12 Rg3 exerts a variety of pharmacological properties including anti-tumor, anti-in fl ammation, treatment of diabetes, anti-pruritic ...
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Original Article Suramin combined with ginsenoside Rg3 alleviates cascular lesions and adventitial inflammation in venous allografts
... pound considered to be an active ingredient in ginseng [9]. It could induce macrophage M2 polarization and promote inflammation regres- sion. Thus, it could be used as a therapeutic drug improving allergic inflammatory ...
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<p>20(R)-Ginsenoside Rg3 Influences Cancer Stem Cell Properties and the Epithelial-Mesenchymal Transition in Colorectal Cancer via the SNAIL Signaling Axis</p>
... 11 Ginsenoside Rg3, a protopanaxadiol-type ginsenoside, is a pharmacologically and physiologically active natural constituent of ginseng that has been demonstrated to exert various biological ...
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Original Article Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patient with acute leukemia via inhibiting the activation of PI3K/Akt and ERK1/2 pathways
... leukemia. Ginsenoside Rg3 has been commonly used in anti-angiogenic therapy of solid ...of Rg3 in patients with acute ...with Rg3 and the expression of vascular endothelial growth factor ...
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Evaluation of Antifatigue Effects of 20(S)-Ginsenoside Rg3 in Forced Swimming Mice
... 20(S)-ginsenoside Rg3 using forced swimming test in ...20(S)-ginsenoside Rg3-treated ...20(S)-ginsenoside Rg3 (10, 20 and 40 ...20(S)-ginsenoside Rg3 significantly ...
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Original Article 20(S)-ginsenoside Rg3 protects myocardium by inhibiting AGE-RAGE-mediated oxidative stress in diabetic rats
... senoside Rg3 on diabetes-related myocardial ...20(S)-ginsenoside Rg3 for 12 ...20(S)-ginsenoside Rg3 resulted in an obvious recovery of these indexes, decreased accumulation of ...
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<p>Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer’s Disease: A State-of-the-Art (2017–2020)</p>
... ciency (%) In Vitr o In Viv o Ginsenoside Rg3 PLGA 115 0.081 NA 65 – 70 In C6 cells : cellular uptak e In THP-1 cells : reduced A β -induced am yloid plaques formation, o xidative str es[r] ...
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Preparation of PEGylated Liposomal Ginsenoside;Formulation Design and in vitro Evaluation
... study, ginsenoside Rg3-loaded PEGylated liposomes were prepared and optimized using the Box- Behnken ...with ginsenoside Rg 3 -loaded liposomes in ...stability ginsenoside Rg3-loaded ...
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Rg3 enriched ginseng extract ameliorates scopolamine induced learning deficits in mice
... that ginsenoside Rg3 significantly decreases the levels of amyloid-β40 and amyloid-β42 in cul- tured cells and transgenic mice (Tg2576) that express high levels of amyloid-β ...[28]. Ginsenoside ...
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Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer
... addition, ginsenoside Rg3 has been developed as a class I new drug in traditional Chinese medicine (Shenyi capsule) and is used clinically in China for the treatment of various types of cancer, including ...
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Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria
... Results: When incubated anaerobically with pooled gut bacteria, Rb1 generated five metabolites, namely Rd, F2, Cpd K, and the rare gypenosides XVII (G-XVII) and LXXV (G-LXXV). The gypenoside pathway (Rb1 → G-XVII → ...
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Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
... of ginsenoside Rg1, Re, Rd, Rb1 and ophiopogonin D in rat plasma by liquid chromatography/electrospray ionization mass spectrometric method and its application to pharmacokinetic study of ‘ SHENMAI ’ ...
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Original Article Pharmacokinetic study on ginsenoside Rg
... Standard compounds ginsenoside Rg 1 (Lot: 110703-200726, purity > 98.0%), and Re (Lot: 110754-200822, purity > 98.0%) were all pur- chased from National Institute for the Control of Pharmaceutical and ...
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