GlcNAc, N-acetylglucosamine
N-Acetylglucosamine (GlcNAc)-Inducible Gene GIG2 Is a Novel Component of GlcNAc Metabolism in Candida albicans
... is N-acetylglucosamine (GlcNAc), which is now established as an important carbon source for many pathogens and can also act as a signaling ...Although GlcNAc catabolism has been well studied ...
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DYSREGULATION OF O-LINKED β-N-ACETYLGLUCOSAMINE (O-GLCNAC) CYCLING SUPPORTS TUMORIGENICITY OF CANCERS OF THE FEMALE REPRODUCTIVE TRACT, Nicole Jaskiewicz
... While pharmacological manipulation is an important tool for preliminary research, these small molecule inhibitors can have unintended consequences. Thus, molecular tools have become critical for advancing our knowledge. ...
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Unique Microbial Catabolic Pathway for the Human Core N Glycan Constituent Fucosyl α 1,6 N Acetylglucosamine Asparagine
... or N-glycosidic bonds ...an N-acetylgalactosamine, which is elongated by additional sugars (8). N-Glycosylation is a common modification of extracellular membrane proteins present at the ...
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N-Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome
... utilize N-acetylglucosamine (GlcNAc) to manipulate the environmental pH ...in N-acetylglucosamine transport and catabolism display morphological and pH neutralization defects within ...
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User-friendly extraction and multistage tandem mass spectrometry based analysis of lipid-linked oligosaccharides in microalgae
... Moreover, N-glycosylation ensures the conformation, the stability and the biological function of glycoproteins ...plants, N-glycosylation has been widely studied, mainly in Arabidopsis thaliana and ...
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Regulation of Hyphal Growth and N-Acetylglucosamine Catabolism by Two Transcription Factors in Candida albicans
... sugar N-acetylglucosamine (GlcNAc) is increasingly recognized as an important signaling molecule in addition to its well-known structural roles at the cell ...albicans, GlcNAc stimulates ...
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Relative accessibility of N-acetylglucosamine in trimers of the adenovirus types 2 and 5 fiber proteins.
... Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest 27 KDa- The fiber protein from Ad2 and AdS has been shown to contain O-GlcNAc residues by a number of different criteria[r] ...
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Structural and functional determination of homologs of the Mycobacterium tuberculosis N acetylglucosamine 6 phosphate deacetylase (NagA)
... a GlcNAc-6-phosphate deacetylase enzyme, NagA (Rv3332), that belongs to the amidohydrolase ...of GlcNAc-6-phosphate (GlcNAc6P) to glucosamine-6-phosphate ...
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The involvement of beta-1,4-galactosyltransferase and N-acetylglucosamine residues in fertilization has been lost in the horse
... and GlcNAc are involved in sperm-zona pellu- cida binding in bovine, but not in porcine, our aim was to clarify the role of GalTase and GlcNAc in another ungu- ...and GlcNAc are involved in ...
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A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on 13C mass isotopologue profiles under non-steady-state conditions
... both N- linked and O-linked glycosylation of proteins, which are important in regulating numerous cellular processes, such as protein targeting to organelles [14] and nutrient sensing ...
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N Acetylglucosamine Induced Cell Death in Candida albicans and Its Implications for Adaptive Mechanisms of Nutrient Sensing in Yeasts
... The copper-sensing transcription factor Mac1 regulates GICD in C. albicans. To further explore the regulatory mecha- nism, we screened a library of 165 transcription factor mutants for mutants defective in GICD (21). As ...
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Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4
... O-linked N-acetylglucosamine ( O -GlcNAc). O - GlcNAc is linked to serine or threonine residues in pro- teins through a reaction catalyzed by O-linked-β-N-acet- ...
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The Plant Pathogen Xanthomonas campestris pv campestris Exploits N Acetylglucosamine during Infection
... tris GlcNAc CUT system, with the TBDTs NixC and NixD being involved in the uptake of oligomers ranging from 2 to 6 GlcNAc residues, NixC being the major transporter for large oligomers ...of GlcNAc ...
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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
... linked N-acetylglucosamine modification and decreases O-linked phosphorylation of the transcription factor Sp1, the effect of hyperglycemia and the hexosamine pathway on eNOS was ...O-linked ...
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Advances in understanding glycosyltransferases from a structural perspective
... Glycogenin is a metal dependent GT-8 retaining enzyme responsible for synthesizing 6-10 a-1,4-linked glucose residues using UDP-Glc as the substrate donor. Glyco- genin employs an unusual mechanism as the oligosac- ...
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Poly N Acetylglucosamine Expression by Wild Type Yersinia pestis Is Maximal at Mammalian, Not Flea, Temperatures
... IMPORTANCE Yersinia pestis transitions from low-temperature residence and replication in insect vectors to higher-temperature replication in mammalian hosts. Prior findings based primarily on an avirulent derivative of ...
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Fibroblasts from patients with I cell disease and pseudo Hurler polydystrophy are deficient in uridine 5' diphosphate N acetylglucosamine: glycoprotein N acetylglucosaminylphosphotransferase activity
... acetylglucosamine:glycoprotein N-acetylglucosaminylphosphotransferase, the first enzyme of the ...The N-acetylglucosaminylphosphotransferase activity (assayed using endogenous acceptors) in cultures from ...
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An acidic, thermostable exochitinase with β-N-acetylglucosaminidase activity from Paenibacillus barengoltzii converting chitin to N-acetyl glucosamine
... The chitinase activity was assayed as described by Lee et al. [16] with minor modifications. The reaction mixture containing 0.1 mL of suitably diluted enzyme solution and 0.1 mL of 1% (w/v) colloidal chitin solution was ...
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Identification of Bacillus anthracis by using monoclonal antibody to cell wall galactose N acetylglucosamine polysaccharide
... subtilis PAl strain 1S53 into which the PA gene was cloned, using cloning vector pUB110 16 were treated with the hybridoma cell culture fluids containing polysaccharide MAbs 5G4 and 6G6.[r] ...
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Engineering the yeast Yarrowia lipolytica for the production of therapeutic proteins homogeneously glycosylated with Man8GlcNAc2 and Man5GlcNAc2
... glycans are typically elongated in the Golgi of yeast, which often results in hypermannosylation. To avoid this, we inactivated the OCH1 gene, which encodes the Golgi α-1,6-mannosyltransferase (α-1,6ManT), which ...
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