Glial activation
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK
... Trigeminal neuropathic pain following trigeminal nerve injury is often difficult to diagnose and treat due to complexity of TN mechanisms [30–33]. Accumu- lating evidence suggests that translation regulation at the level ...
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Glial activation and inflammation along the Alzheimer’s disease continuum
... increased activation in patients at the AD stage of dementia ...microglial activation and a later inflammatory ...micro- glial activation might induce phagocytosis of Aβ, stalling formation of ...
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Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis
... to replicate these findings, and in addition, show colocalization with a molecular marker of glial activa- tion. One can speculate that we are observing both cause and effect of neurodegeneration. In other words, ...
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Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation
... suppressed glial activation in response to three structurally distinct stimulants (LPS, PIC, and Aβ), (2) the saturable kinetics of interaction, and (3) selectivity for some, but not all, induced ...
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Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain
... modulate glial responsiveness and are suggested to be crucial for glial proliferation and the release of important trophic factors to support brain plasticity [42, ...regarding glial ...
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Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation
... CHOP, also known as growth arrest-inducible and DNA damage-inducible gene 153 (GADD153), is the proapoptotic protein that mediates ER stress-induced apoptosis [14]. CHOP has been reported to play a pivotal role in ...
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Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
... Since we demonstrated that cytokine stimulated neuronal cells increased production of A β by transcriptional BACE1 up-regulation in vitro [18], and the latter cytokines were detectable at sites of early inflammation in ...
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Neurotransmitter receptors on microglia
... the activation of neuronal ion channels to micro- glial ...microglial activation, whereas the ‘ off ’ signal serves to contain microglia and keeps them in the default, non-activated ...
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Innate immunity in the Grid2Lc/+ mouse model of cerebellar neurodegeneration: glial CD95/CD95L plays a non-apoptotic role in persistent neuron loss-associated inflammatory reactions in the cerebellum
... the glial cell reaction to neuron loss by following glial morpho- logical changes from P5 to adulthood by GFAP immunolabeling for astrocytes and the histoenzymatic nucleoside diphosphatase method for ...of ...
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Minocycline attenuates interferon-α-induced impairments in rat fear extinction
... microglial activation inhibitor ...microglial activation and increased the produc- tion of IL-1β and ...of glial activation in mental disorders associated with innate immunity and underpin the ...
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Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury
... on glial cells is critical to open up novel thera- peutic ...and glial cells as well as on their crosstalk mechanisms to being able to develop TMS approaches for modulating specific cellular ...
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Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge
... retinal glial cells support the functions of neurons via several mechanisms, including the removal of extracellular glutamate and synthesis of growth factors and metabolites ...Retinal glial cells are ...
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CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL 4
... microglial activation, we show that the addition of neurons to A-treated glia decreased MHCII mRNA expression and also decreased production of IL-1, IL-6, and TNF␣, suggesting that neurons are capable of ...
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Intrathecal Lamotrigine Attenuates Mechanical Allodynia and Suppresses Microglial and Astrocytic Activation in a Rat Model of Spinal Nerve Ligation
... Glial activation responses for microglia and astrocyte Glial responses were assessed in 3 sections chosen at random from the L5 spinal cord ...
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Regulation of α1-adrenoceptor linked phosphoinositide breakdown in cultured glia: role of protein phosphatases
... release from intracellular stores. However, receptor-mediated increases in intracellular Ca^"^ levels can also be caused by influx from the extracellular fluid. Previous work has shown that the effect of NA on pH]-IP ...
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Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells
... microglial activation by secretion of anti-inflammatory substances such as transforming growth factor (TGF) and prostaglandin E2 (PGE2) [122, 123], resembling a M2 phenotype, and may thereby limiting ...
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Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation
... in glial cells with transient transfection with an NFκB reporter plasmid ...reporter activation (Figure 3A and ...in glial cells (Figure 3C and ...both glial cell types (Figure 3C and ...
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Immune reactivity in the nervous system: modulation of T lymphocyte activation by glial cells
... Astrocytes present myelin basic protein to encephalitogenic T cell lines.. prostaglandin E and an interleukin-1 like-factor by astrocytes and C6 glioma cells.[r] ...
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The effect of exercise frequency on neuropathic pain and pain-related cellular reactions in the spinal cord and midbrain in a rat sciatic nerve injury model
... The activation of glial cells (microglia and astrocytes), expression of brain-derived neurotrophic factor (BDNF) and μ-opioid receptor in the spinal dorsal horn and endogenous opioid in the midbrain were ...
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Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes
... cyte activation and subsequent production of inflamma- tory cytokines in vitro, indicating that activated MCs led to a proinflammatory profile in astrocytes ...
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