Glomerular injury
Podocyte specific RAP1GAP expression contributes to focal segmental glomerulosclerosis–associated glomerular injury
... to induce severe glomerular injury. Mice that carried a single intact Rap1 allele (i.e., loss of 3 of 4 Rap1 alleles) in podocytes still developed severe FSGS, although comparatively more moderate than that ...
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Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis
... trophil-mediated glomerular injury (21, 25), these observations suggest that neutrophil recruitment is not dependent on CCR1 in this ...of glomerular crescents and tubulointerstitial disease in ...
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Monocyte chemoattractant protein 1 promotes macrophage mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis
... kidney injury in NSN. Provision of MCP-1 antibody reduces glomerular injury in NSN (29, ...of glomerular protection at day 7 (29), another report claims that protection is transient and is ...
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New mechanism for glomerular injury Myeloperoxidase hydrogen peroxide halide system
... induce glomerular injury by infusing MPO followed by H2O2 in a chloride-containing solution into the renal artery of ...the glomerular basement membrane and mesangium by autoradiography, into ...
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Chronic glucocorticoid therapy amplifies glomerular injury in rats with renal ablation
... and glomerular hypertension despite equivalent renal ablation and, in group 3, comparable doses of ...and glomerular sclerosis, while CEI (groups 7 and 8) afforded striking protection against disease ...
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Podocyte loss and progressive glomerular injury in type II diabetes
... examining glomerular structure in Pima Indians with type II ...examine glomerular structure in Pima subjects in whom the duration of diabetes and the development of clinically appar- ent glomerular ...
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IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury
... of glomerular injury due to LPS and poly- styrene beads are not ...the glomerular basement membrane, and podocytes of epithelial ...mechanical injury due to poly- styrene beads is one of the ...
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Age dependent glomerular damage in the rat Dissociation between glomerular injury and both glomerular hypertension and hypertrophy Male gender as a primary risk factor
... progressive injury with advancing age which is particularly pronounced in males and is not the result of any specific disease ...rats, glomerular function and structure were examined in adult (8 mo), ...
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Intravital imaging of podocyte calcium in glomerular injury and disease
... during glomerular injury and disease progression, this new imaging approach allows simultaneous quantitative functional analysis of the ...and glomerular tuft contraction (Figure 3, A–E), which ...
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Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury
... how glomerular injury may spread to the tubulointerstitium, for example, podocyte damage leading to tubulointerstitial malperfusion, glomerular filtration leakage into the interstitium, or ...
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Outcome of the acute glomerular injury in proliferative lupus nephritis
... glomerular injury. Judged by a progressive reduction in the density of glomerular cells and immune deposits, glomerular inflammation ...in glomerular barrier ...of glomerular ...
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Gq signaling causes glomerular injury by activating TRPC6
... primary glomerular disease processes (29, ...in glomerular diseases, including promoting degradation of the podocyte cytoskeletal protein SYN (22, 62), as well as inducing podocyte apoptosis and podocyte ...
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Instigation of NLRP3 inflammasome activation and glomerular injury in mice on the high fat diet: role of acid sphingomyelinase gene
... chronic glomerular injury associated with obesity or hyperhomocysteinemia and thereby ceramide may serve as an important mechanism of end-stage renal disease [8, ...obesity-induced glomerular ...
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Nephrin: a biomarker of early glomerular injury
... experimental glomerular disease was in- duced in rats by using puromycin aminonucleoside (PAN) ...induce glomerular injury and to in- vestigate the excretion of urinary nephrin as a result of this ...
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Is there a link between diabetic glomerular injury and crescent formation? A case report and literature review
... demonstrated the presence of bilateral pleural effusion. There was no rash or lymphadenopathy, and no petechiae were found. The patient’s heart sounds were normal. Renal sonography revealed that the size of both kidneys ...
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Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass
... that glomerular transcapillary pressure was reduced significantly by converting enzyme inhibition and by AII blockade but not by the combination regimen (delta P: group 1, 49 +/- 1 mmHg; group 2, 42 +/- 1 mmHg; ...
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Deleterious effects of calcium channel blockade on pressure transmission and glomerular injury in rat remnant kidneys
... Abbreviations used in this paper: AG, cross-sectional area; Al, autoregulatory index; C, untreated controls; CCB, calcium channel blockers; E, enalapril; N, nifedipine; PGc, glomerular c[r] ...
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Vascular endothelial growth factor A165b restores normal glomerular water permeability in a diphtheria toxin mouse model of glomerular injury
... of glomerular disease, with no measurable albuminuria apparent within the first weeks after administration of DT and no detectable structural/ultra-structural ...creased glomerular water permeability ...
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Essential role of Gas6 for glomerular injury in nephrotoxic nephritis
... of glomerular diseases by modulating the expression of other growth ...on glomerular basement membranes (GBM), rapid ele- vation of blood urea nitrogen, infiltration of lymphocytes and monocytes, and ...
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Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat
... on glomerular hemodynamics and permselectivity and on subsequent sclerosis was studied in male MWF/Ztm rats which spontaneously develop proteinuria and glomerular structural ...whole-kidney ...
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