GLP-1 receptor activation
GLP-1 RECEPTOR ACTIVATION-BASED THERAPY; A PROMISING STRATEGY AGAINST ISCHEMIC STROKE
... are GLP-1R agonists with neuroprotective effects already in clinical use for the treatment of T2D; their neuroprotective effect is independent of their glycemic ...the GLP-1R neuroprotective window, as well ...
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Pancreatic GLP 1 receptor activation is sufficient for incretin control of glucose metabolism in mice
... Paired, 1-tailed t tests or 2-way ANOVA (with Bonferroni post-hoc analysis) were used to assess the differences in glucose tolerance, gastric emptying, and food intake data, where measurements were repeated on the ...
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GLP 1 receptor agonists show neuroprotective effects in animal models of diabetes
... 2017). GLP-1 receptors are expressed in the brains of rodents, primates and humans (Merchenthaler et ...2016). GLP-1 receptor agonists such as exendin- 4 or liraglutide can reverse ...
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Glucagon like peptide 1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
... of GLP-1 action on the cardiovascular system between various studies may be due in part to experimental dif- ferences in the preparation and handling of the animals and the doses of the agonists used in ...
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Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1
... encodes GLP-1 [16], which is post-translationally processed into various active peptides in a tissue-specific manner ...[17,18]. GLP-1 is an incretin that stimulates cellular glucose up-take ...
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Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
... internalization, GLP-1R/ligand complex could be co-localized with adenylate cyclase in the ...by GLP-1 treatment of mouse cardiomyocytes without increasing intracellular Ca 2+ or inducing ...
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GLP 1 stimulates insulin secretion by PKC dependent TRPM4 and TRPM5 activation
... of GLP-1 by only a few picomolars and yet results in marked stim- ulation of insulin secretion and a fall in plasma glucose levels (5, ...of GLP-1 in neurons (7), skeletal muscle cells (8), ...
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Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer
... and GLP-1R agonists in patients with PTC, we investigated alterations in the PI3K/Akt and MAPK/Erk signaling path- ways after treating PTC cells with these ...of activation of either pathway by the ...
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The arcuate nucleus mediates GLP 1 receptor agonist liraglutide dependent weight loss
... express GLP-1R (Figure 2E), the marked suppression of NPY/AgRP expression that followed chronic liraglutide treatment prompted us to examine the effect of GLP-1R stimulation on NPY ...with ...
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Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.
... that GLP-1RA has an anti-fibrosis effect on several organs, including the ...that GLP-1 receptor can be detected on the surface of HSCs Wu LK, (2013), et ...of GLP-1RA might also be ...
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Extra Glycemic Impacts of GLP 1 Receptor Agonists: Benefits of a Class Effect?
... continuous activation of the GLP-1 receptor and less fluctu- ations in peptide levels ...at 1 mmol/L more than exena- tide [34] [40] ...the GLP-1 RAs has been compared to ...
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A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics
... active GLP-1R structures, there are a number of differences that need to be resolved for a full understanding of agonist binding and activation ...since GLP-1 straddles the two domains in ...
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Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition
... of GLP-1 receptor and positions of missense changes encoded by glp-1(Pro) ...three glp-1(Pro) mutations are given for three related proteins: LIN-12 from ...
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Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway
... During 37°C digestion, Ca 2+ -free enzymatic solution containing trypsin was gradually replaced with another enzymatic solution containing 0.1 mM of Ca 2+ , 0.075% collagenase, 0.1% soybean trypsin inhibitor, and 0.2% ...
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A novel dual GLP 1/GIP receptor agonist alleviates cognitive decline by re sensitizing insulin signaling in the Alzheimer icv STZ rat model
... peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP), promising antidiabetic agents for the treatment of type 2 diabetes, have been tested in models of neurodegenerative disease ...
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Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists
... In Glp-1r KO animals, unpublished observations from our group, revealed that these animals presented with a reduction in cancellous bone volume associated with a lower trabeculae numbers and higher trabecular ...
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Original Article Genomic and morphoproteomic correlates implicate the IGF-1/mTOR/Akt pathway in the pathogenesis of diffuse congenital hyperinsulinism
... (Table 1, patients 2 and 4; and Figures 3 and 4) has confirmed the overexpres- sion of constitutively activated mTOR phos- phorylated on serine 2448 in the acinar cells, and correlative expressions of insulin-like ...
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CNS targeting pharmacological interventions for the metabolic syndrome
... the activation of melanocortin-3 and -4 receptor–positive (MC3/4R-positive) neurons in the paraventricu- lar nucleus via direct synaptic innervation or via the concomitant release of the neuropeptide MC3/4R ...
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Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics
... respective receptor, GLP-1R, is a G-protein coupled receptor of seven-transmembrane topology [23, 32, 33, ...highest GLP-1R incidence and density in insulinomas [32, 33, 42]. GLP-1R is ...
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Efficacy and Safety of Basal Supported Prandial GLP 1 Receptor Agonist Therapy
... growing rapidly worldwide. Some 415 million people, or 8.8% of adults aged 20 - 79 years, have diabetes; among these, 94.2 million people (22.7%) are aged 65 - 79 years. If these trends continue, by 2040 some 642 million ...
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