GLP-1 receptor (GLP-1R)
Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1
... of GLP-1 is not only to decrease blood sugar, but also acts as a neurotrophic factor that plays a role in neuronal survival, neurite outgrowth, and protects synaptic plasticity and memory formation from ...
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A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics
... in 1]. As such, the GLP-1 receptor (GLP-1R) has been successfully targeted for anti-diabetic and anti-obesity therapy through the discovery of a number of peptidic GLP-1 ...
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A comparison of three 67/68Ga-labelled exendin-4 derivatives for β-cell imaging on the GLP-1 receptor: the influence of the conjugation site of NODAGA as chelator
... peptide receptor-1 (GLP-1R) would allow the assessment of both β -cell mass and derived tumours, potentially improving the diagnosis of various ...of GLP-1R, in vitro and in ...the ...
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Pancreatic GLP 1 receptor activation is sufficient for incretin control of glucose metabolism in mice
... or GLP-1 secreted by the intes- tine actually reaches β cells in active form, rendering uncertain the mechanisms underlying the classical incretin concept (11, ...12). GLP-1 also exerts ...
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Role and development of GLP-1 receptor agonists in the management of diabetes
... exogenous GLP-1 – increasing insulin secretion from β cells, suppressing gluca- gon secretion from α cells, decreasing post-prandial glucose excursion through delay in gastric emptying, increasing post- ...
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GLP 1 receptor agonists show neuroprotective effects in animal models of diabetes
... 2017). GLP-1 receptors are expressed in the brains of rodents, primates and humans (Merchenthaler et ...2016). GLP-1 receptor agonists such as exendin- 4 or liraglutide can reverse ...
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GLP-1 RECEPTOR ACTIVATION-BASED THERAPY; A PROMISING STRATEGY AGAINST ISCHEMIC STROKE
... (GLP-1) receptor agonists are novel antidiabetic agents with a proved neuroprotection ...of GLP-1 use as a neuroprotective approach against DM-associated ...
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Short term monotherapy with GLP-1 receptor agonist liraglutide or PDE 4 inhibitor roflumilast is superior to metformin in weight loss in obese PCOS women: a pilot randomized study
... of GLP-1 receptor agonist [5, 17] and metformin or com- bination of roflumilast and metformin [10], which might suggest a possible additive role of metformin to GLP-1 mediated effect ...
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Emerging role of GLP-1 receptor agonists in the treatment of obesity
... GLP-1 receptor agonists have proven to be a very useful option in the treatment of type 2 diabetes, particularly in overweight and obese ...future, GLP-1 receptor agonists may ...
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Is there a justification for classifying GLP-1 receptor agonists as basal and prandial?
... various GLP-1 receptor agonists on glucose levels have been analyzed in phase III placebo- controlled randomized trials within the framework of drug development programs such as AMIGO (exena- tide), ...
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GLP 1 receptor agonists for Parkinson's disease (Protocol)
... of GLP-1 receptor agonists for PD, as this will provide a summary of the current state of the evidence, as well as providing a platform for updating the evidence base as future studies ...
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Extra Glycemic Impacts of GLP 1 Receptor Agonists: Benefits of a Class Effect?
... the GLP-1 receptor and less fluctu- ations in peptide levels ...at 1 mmol/L more than exena- tide [34] [40] ...the GLP-1 RAs has been compared to exenatide or liraglutide, the ...
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Efficacy and Safety of Basal Supported Prandial GLP 1 Receptor Agonist Therapy
... Overall, while no difference was observed in HbA1c over the 4-month study pe- riod, a 1.5 kg decrease in body weight was observed (p < 0.001). There was no change in the frequency of hypoglycemia. Hypoglycemia and ...
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Prediction of response to GLP-1 receptor agonist therapy in Japanese patients with type 2 diabetes
... of GLP-1 receptor agonist ...to GLP-1 receptor agonist therapy after the initiation of therapy was preserved and pos- sessed the ability to predict a long-term improvement in ...
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Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.
... that GLP-1RA has an anti-fibrosis effect on several organs, including the ...that GLP-1 receptor can be detected on the surface of HSCs Wu LK, (2013), et ...of GLP-1RA might also be ...
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Choosing GLP-1 Receptor Agonists or DPP-4 Inhibitors: Weighing the Clinical Trial Evidence
... recommendations, GLP-1 receptor agonists and DPP-4 inhibi- tors are useful in the management of patients with type 2 diabetes over the spectrum of A1C levels, including drug-naive patients as well as ...
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The GLP 1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK dependent mechanism
... Results: Time course experiments show that EXE increases glucose uptake up to 48 h achieving its maximal effect, similar to that induced by insulin, after 20 min (2- vs 2.5-fold-increase, respectively). Differently from ...
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Evaluating preferences for profiles of GLP-1 receptor agonists among injection-naïve type 2 diabetes patients in the UK
... two GLP-1 receptor agonist medications, the most important factors in patients’ decisions in rank order were: “dosing frequency,” “type of delivery device,” “frequency of nausea,” “weight change,” ...
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Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics
... respective receptor, GLP-1R, is a G-protein coupled receptor of seven-transmembrane topology [23, 32, 33, ...highest GLP-1R incidence and density in insulinomas [32, 33, 42]. GLP-1R is ...
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The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively.
... human GLP-1R and GIPR subcloned into ...USA). GLP-1R and GIPR were subsequently re-ligated into ...YFP-labelled GLP-1R and GIPR (GLP- 1-YFP and GIPR-YFP) were purchased from Source ...
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