glucagon-like peptide
Glucagon like peptide 1 receptors in the brain: controlling food intake and body weight
... The peptide hormone glucagon-like peptide-1 (GLP-1) enhances glucose-induced insulin secretion and inhibits both gastric emptying and glucagon ...small peptide GLP-1R agonist ...
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Hepatic and glucagon like peptide 1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
... block glucagon signaling and thereby regulate glucose metabolism do not ...blocking glucagon action would reverse hyperglycemia, we targeted the glucagon receptor (GCGR) in rodent models of type 2 ...
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The effect of a glucagon-like peptide-1 receptor agonist on glucose tolerance in women with previous gestational diabetes mellitus: protocol for an investigator-initiated, randomised, placebo-controlled, double-blinded, parallel intervention trial
... Studies show that, on average, patients with T2D are diag- nosed when their relative β -cell function is approximately 50% of normal. 7 The delayed onset of symptoms makes it dif fi cult to characterise the pathogenesis ...
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Adherence to antihyperglycemic medications and glucagon-like peptide 1-receptor agonists in type 2 diabetes: clinical consequences and strategies for improvement
... of glucagon-like peptide 1-receptor agonists, which are a focus of this narrative ...of glucagon-like peptide 1-receptor agonists, may thus lead to improved clinical outcomes in ...
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Glucagon like peptide isolated from the eel intestine: effects on atrial beating
... We have determined that the eel atrium provides a suitable bioassay system, because it is both easy to prepare and is sensitive to peptides. The eel atrium can be easily isolated from the heart and beats spontaneously ...
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Glucagon like peptide 1 promotes satiety and suppresses energy intake in humans
... infused glucagon- like peptide 1 (GLP-1) on subjective appetite sensations af- ter an energy-fixed breakfast, and on spontaneous energy intake at an ad libitum ...insulin, glucagon, and blood ...
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Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review
... foods on glycemic response, subjective appetite sensa- tions as well as energy intake at a subsequent meal [151–168]. The main findings of these studies are sum- marized in Table 3. Several researchers have investigated ...
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Long-term management of type 2 diabetes with glucagon-like peptide-1 receptor agonists
... options. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are an emerging therapeutic class that can be prescribed for patients instead of basal insulin after the failure of oral ...
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Differential effects of glucagon-like peptide-1 receptor agonists on heart rate
... While glucagon‑like peptide‑1 receptor agonists (GLP‑1 RAs) are known to increase heart rate (HR), it is insufficiently recognized that the extent varies greatly between the various agonists and is ...
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Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
... Best JH, Hoogwerf BJ, Herman WH, Pelletier EM, Smith DB, Wenten M, Hussein MA: Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide[r] ...
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Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer
... Previous studies have expressed concerns that insulin, insulin analogs, and glucagon-like peptide-1 receptor (GLP-1R) agonists might contribute to increased risk of some types of cancer. The present ...
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Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists
... that Glucagon-like peptide-1 receptor (GLP-1r) agonists, now greatly prescribed for the treatment of T2DM, have beneficial skeletal effects although the underlying mechanisms are not completely ...
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A novel, long-acting glucagon-like peptide receptor-agonist: dulaglutide
... If patients fail to achieve satisfactory control on metformin, another oral glucose-lowering drug is added, usually SU added to metformin (a combination of two oral agents is referred to as “dual therapy”). When dual ...
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Glucagon-like peptide-1 receptor agonists: a systematic review of comparative effectiveness research
... GLP-1RA, glucagon-like peptide-1 receptor agonist; HbA1c, glycated hemoglobin; HeeLA, Helping evaluate exenatide in Patients with Diabetes Compared with Long-Acting insulin; iAsp, insulin aspart; ...
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Lixisenatide: A New Member of the Glucagon-Like Peptide 1 Receptor Agonist Class of Incretin Therapies
... L ixisenatide is a once-daily (QD), fixed-dose glucagon-like peptide 1 (GLP-1) receptor agonist. As an antidiabetic drug that is associated with a minimal risk of hypoglycemia and little likelihood ...
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Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway
... new glucagon-like peptide isolated from the intestine of the eel, Anguilla japonica[21] with a structure similar to that of oxynto- modulins has shown an inotropic effect via stimulation of Ca 2+ ...
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Glucagon like peptide 1 can reverse the age related decline in glucose tolerance in rats
... insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), two hormones secreted from neuroendocrine cells of the gut, have the most potent insulin- secreting effect (1, ...
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Incretin System: Recent Advances in Glucagon Like Peptide-1 and Dipeptidyl Peptidase-4 Inhibitors
... and Glucagon-like peptide, are peptide hormones secreted from endocrine cells in the small ...intestine. Glucagon-like peptide-1 stimulates insulin and suppresses ...
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Glucagon like peptide analogues for type 2 diabetes mellitus
... For overview of results please see Appendix 2. Seventeen ran- domised controlled trials of mostly low risk of bias including rele- vant analyses for 6899 participants were included in the analysis. Of these, one compared ...
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Glucagon-Like Peptide 1-Based Therapies for Type 2 Diabetes: A Focus on Exenatide
... GLP-1–based therapy would be a novel and complementary approach to dia- betes management for several reasons. It is the first insulin secretagogue that does not cause hypoglycemia. It does not cause the weight gain that ...
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