Glucagon-Like Peptide-1
A Novel Pancreatropic Coxsackievirus Vector Expressing Glucagon-Like Peptide 1 Reduces Hyperglycemia in Streptozotocin-Treated Mice
... for glucagon-like peptide 1 (GLP-1), a peptide that enhances pancreatic regeneration following tissue ...type 1 and 2 diabetes, pancreatitis, and pancreatic ...
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The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling
... Glucagon-like peptide-1 (7–36)amide (GLP-1) plays a central role in regulating blood sugar levels and its receptor, GLP-1R, is a target for anti-diabetic agents such as the ...
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Differential effects of glucagon-like peptide-1 receptor agonists on heart rate
... While glucagon‑like peptide‑1 receptor agonists (GLP‑1 RAs) are known to increase heart rate (HR), it is insufficiently recognized that the extent varies greatly between the various ...
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Glucagon like peptide 1 promotes satiety and suppresses energy intake in humans
... infused glucagon- like peptide 1 (GLP-1) on subjective appetite sensations af- ter an energy-fixed breakfast, and on spontaneous energy intake at an ad libitum ...insulin, ...
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Glucagon-like peptide-1 receptor agonists: a systematic review of comparative effectiveness research
... GLP-1RA, glucagon-like peptide-1 receptor agonist; HbA1c, glycated hemoglobin; HeeLA, Helping evaluate exenatide in Patients with Diabetes Compared with Long-Acting insulin; iAsp, insulin ...
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Glucagon like peptide 1 receptors in the brain: controlling food intake and body weight
... The peptide hormone glucagon-like peptide-1 (GLP-1) enhances glucose-induced insulin secretion and inhibits both gastric emptying and glucagon ...small peptide ...
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Long-term management of type 2 diabetes with glucagon-like peptide-1 receptor agonists
... options. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are an emerging therapeutic class that can be prescribed for patients instead of basal insulin after the failure of oral ...
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Glucagon like peptide 1 can reverse the age related decline in glucose tolerance in rats
... insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), two hormones secreted from neuroendocrine cells of the gut, have the most potent insulin- secreting effect ...
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Lixisenatide: A New Member of the Glucagon-Like Peptide 1 Receptor Agonist Class of Incretin Therapies
... L ixisenatide is a once-daily (QD), fixed-dose glucagon-like peptide 1 (GLP-1) receptor agonist. As an antidiabetic drug that is associated with a minimal risk of hypoglycemia and ...
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GLP-1(28-36)amide, the Glucagon-like peptide-1 metabolite: friend, foe, or pharmacological folly?
... The glucagon-like peptide-1 (GLP-1) axis has emerged as a major therapeutic target for the treatment of type 2 ...type 1 diabetes also improves glucose disposal concomitant with ...
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A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics
... Glucagon-like peptide-1 (GLP-1) is a hormone secreted by enteroendocrine L cells in response to ...in 1]. As such, the GLP-1 receptor (GLP-1R) has been successfully ...
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Exendin(9 39)amide is an antagonist of glucagon like peptide 1(7 36)amide in humans
... hormone, glucagon-like peptide-1(7-36)amide (GLP-1) is released after a ...inhibiting glucagon secretion indicates the putative physiological function of ...nonmammalian ...
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Hepatic and glucagon like peptide 1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
... block glucagon signaling and thereby regulate glucose metabolism do not ...blocking glucagon action would reverse hyperglycemia, we targeted the glucagon receptor (GCGR) in rodent models of type 2 ...
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Age dependent human β cell proliferation induced by glucagon like peptide 1 and calcineurin signaling
... proliferation include PDGF, prolactin (PRL), and glucagon-like peptide 1 (GLP-1). Recent studies have elucidated crucial signal transduction elements of these mitogens in β cells (4, ...
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64Cu Labeled Sarcophagine Exendin-4 for MicroPET Imaging of Glucagon like Peptide-1 Receptor Expression
... The Glucagon-like peptide 1 (GLP-1) is an incretin peptide released from the intestine in response to nutrient ingestion; its binding to the GLP-1 receptor (GLP-1R) ...
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Elevated circulating fasting glucagon-like peptide-1 in surgical patients with aortic valve disease and diabetes
... hormone glucagon-like peptide-1 (GLP- 1) may provide clues to some of the mechanisms under- lying the inverse relationship of diabetes and ...a peptide hormone with a central ...
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Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis
... receptor 1 (GPBAR1; TGR5) and serve as hormone to control various biological processes, including cholesterol/bile acid metabolism, glucose/lipid metabolism, immune responses, and energy ...of ...
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Glucagon-like peptide-1 (GLP-1) mediates the protective effects of dipeptidyl peptidase IV inhibition on pulmonary hypertension
... as glucagon-like peptide-1 (GLP-1) [12]. GLP-1, an incretin hormone derived from enter- oendocrine cells, can be rapidly degraded by DPP-4, resulting in a short half-life time ...
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Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
... the glucagon- like peptide-1 receptor (GLP-1R) agonist exendin-4 (EX- 4) shows neurotrophic [10] and 'neuroprotective' [11] properties in cultured PC12 cells subjected to excitotoxic ...GLP- ...
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Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists
... that Glucagon-like peptide-1 receptor (GLP-1r) agonists, now greatly prescribed for the treatment of T2DM, have beneficial skeletal effects although the underlying mechanisms are not ...
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