glucagon-like peptide-l
BARIATRIC SURGERY AND ITS EFFECT ON THE METABOLIC ASPECT IN DIET INDUCED OBES RAT MODEL
... Leptin, glucagon-like peptide-1 (active), ghrelin (active), homeostatic model (HOMA) assessment were measured by using this formula: fasting glucose (mmol/L) × insulin ...
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Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis
... Quite interestingly, another recent study has demonstrated that FXR activation mediated by a gut-specific FXR agonist, Fexaramine stimulates TGR5 expression in the intestinal L cells to potentiate TGR5-mediated ...
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Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer
... Activation of the PI3K/Akt and/or MAPK/Erk signaling pathways is related to cell proliferation in PTC; therefore, after treatment with a certain concentration (1,500 nmol/L) of natural insulin or insulin analogs ...
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Glucagon like peptide isolated from the eel intestine: effects on atrial beating
... mmol l −1 NaCl Ringer’s solution (hyperosmotic), guanylin (an intestinal peptide composed of 15 amino acid residues) secretion into the lumen increased threefold, accompanied by a slight increase in ...
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Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review
... from L-cells is likely mostly acting on the central nervous system by indirectly stimu- lating neurons of the NTS and ARC via the activation of vagal afferent neurons ...
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Circulating glucagon-like peptide-1 increases in response to short-term overfeeding in men
... A limitation of this investigation is that only young men (age 19–29) of Newfoundland descent were studied for one week; therefore similar studies are needed in fe- males, and subjects of different age ranges and ethnic ...
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A novel, long-acting glucagon-like peptide receptor-agonist: dulaglutide
... level less than 50 mg/dL [3.4 mmol/L] or with prompt recovery after oral carbohydrate or glucagon or intrave- nous glucose) (DCCT 1993), serious (life threatening or required subject to be admitted to ...
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Glucagon like peptide analogues for type 2 diabetes mellitus
... 2009; L - Yang 2010; Lixi - Ratner 2010; LY2189265 -Umpierrez 2011; T - Nauck 2009; T- Ratner 2010), and the remaining trials were between 24 to 30 weeks long - so there is insufficient evidence regarding ...
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Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway
... new glucagon-like peptide isolated from the intestine of the eel, Anguilla japonica[21] with a structure similar to that of oxynto- modulins has shown an inotropic effect via stimulation of Ca 2+ ...
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Single-dose acarbose decreased glucose-dependent insulinotropic peptide and glucagon levels in Chinese patients with newly diagnosed type 2 diabetes mellitus after a mixed meal
... are glucagon-like peptide-1 (GLP-1) and glucose- dependent insulinotropic peptide ...intestinal L cells when triggered by ingested nutri- ents, while GIP is released from intestinal K ...
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The effect of a glucagon-like peptide-1 receptor agonist on glucose tolerance in women with previous gestational diabetes mellitus: protocol for an investigator-initiated, randomised, placebo-controlled, double-blinded, parallel intervention trial
... C-peptide, glucagon, GLP-1 and GIP will be drawn throughout the ...a glucagon test will be per- formed; at time point 0 min, 1 mg glucagon will be injected and at time points 2, 6 and 10 min, ...
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Emerging treatment options for short bowel syndrome: potential role of teduglutide
... primary efficacy endpoint was defined as the percentage of patients who achieved a 20% or greater reduction in weekly PN volume at weeks 20 and 24. In an intention- to-treat analysis, 63% (27/43) of teduglutide-treated ...
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Exenatide infusion decreases atrial natriuretic peptide levels by reducing cardiac filling pressures in type 2 diabetes patients with decompensated congestive heart failure
... hospitalization for CHF according to NYHA III-IV cri- teria, left ventricular (LV) systolic dysfunction with a documented LV ejection fraction of ≤35 % (assessed by echocardiography), and clinically stable period of 24 h ...
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Glucagon like peptide 1 receptors in the brain: controlling food intake and body weight
... small peptide versus high-molecular-weight GLP-1R agonists at the relevant CNS GLP-1Rs, or simply an incompletely explored dose- response relationship remains ...additional peptide agonists to achieve ...
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Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists
... To address this issue, a few studies were conducted examining if sclerostin production by osteocytes is modified in bone of diabetic rodents or in vitro when osteocytes are cultured in high glucose levels. ...
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Glucagon-like peptide-1 receptor agonists: a systematic review of comparative effectiveness research
... GLP-1RA, glucagon-like peptide-1 receptor agonist; HbA1c, glycated hemoglobin; HeeLA, Helping evaluate exenatide in Patients with Diabetes Compared with Long-Acting insulin; iAsp, insulin aspart; ...
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Chitosan oligosaccharide improves the therapeutic efficacy of sitagliptin for the therapy of Chinese elderly patients with type 2 diabetes mellitus
... The use of a combined treatment improves glycemic and weight control in most subjects with T2DM. Meanwhile, the levels of C peptide, β -cell function index, and adiponectin are also increased. Theoretically, ...
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Practical Use of Glucagon-Like Peptide-1 Receptor Agonist Therapy in Primary Care
... tions relatively simple. Liraglutide and exenatide BID are delivered with pen devices with 31- or 32-gauge needles, whereas exenatide QW has a delivery kit that simplifies the mixing of diluent and powdered medication ...
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Glucagon-Like Peptide 1-Based Therapies for Type 2 Diabetes: A Focus on Exenatide
... Furthermore, increased C-peptide levels suggest that the increase in insulin levels was related to increased secretion and not to a reduction in insulin clearance. Basal glucagon levels fell, and glucose ...
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Receptors and effects of gut hormones in three osteoblastic cell lines
... Decreased P1NP concentrations were observed in supernatants from early osteoblasts-like (MG-63 and TE-85) after long exposure to GIP, GLP-1, GLP-2, OB in TE-85 and after GLP-1 in MG-63 cells. Short expo- sure did ...
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