Glucocorticoid receptor (GR)
Unraveling the glucocorticoid receptor pathway in zebrafish
... the glucocorticoid receptor (GR) which acts as a transcription factor, regulating a wide plethora of ...by GR signaling have not fully been ...synthetic glucocorticoid beclomethasone, ...
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Regulation of triglyceride metabolism by glucocorticoid receptor
... intracellular receptor, the glucocorticoid receptor ...ligands, GR associates with genomic glucocorticoid response ele- ments (GRE) to modulate the transcription of nearby genes (called ...
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A Genetic Analysis of Glucocorticoid Receptor Signaling: Identification and Characterization of Ligand-Effect Modulators in Saccharomyces cerevisiae
... Figure 3.—Phenotypes of lem3 and lem4 mutants involve different GR domains. (A) Schematic of glucocorticoid receptor functional domains. Enh2/AF1 is the N-terminal regulatory domain that harbors ...
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Glucocorticoid Receptor Nuclear Translocation in CD4 T Cells from Severe and Moderate Asthmatic Patients Treated with Fluticasone/Vilanterol
... verify glucocorticoid receptor glcococorticoid receptor (GR) nuclear translocation in CD4 T cells treated with fluticasone furoate (FF), vilanterol (V) and FF/V combination in severe asthmatic ...
8
Human small cell lung cancer cell lines expressing the proopiomelanocortin gene have aberrant glucocorticoid receptor function
... the glucocorticoid receptor (GR) in the SCLC cell line COR L24 using a whole cell ligand binding assay (Kd = ...significant glucocorticoid binding. To analyze GR function both positive ...
7
Expression of Glucocorticoid Receptor Isoforms (a, β, γ, and p) in Egyptian Primary Immune Thrombocytopenia Patients
... of glucocorticoid receptors ...determining glucocorticoid receptor (GR) isoforms expression in adult ITP and its relation to glucocorticoid ...included. Glucocorticoid ...
8
Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring
... of glucocorticoid receptor (GR) mRNA and phosphoenolpyru- vate carboxykinase (PEPCK) mRNA (and activity) are in- creased by 25% ( P 5 ...and GR ex- pression. The increased hepatic GR ...
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Glucocorticoid receptor polymorphism in obesity and glucose homeostasis
... Glucocorticoid receptor (GR) activity plays a significant role in the etiology of obesity and is essential for glucose homeostasis, the development of hyperinsulinaemia and subsequent increased fat ...
6
Case control study of glucocorticoid receptor and corticotrophin releasing hormone receptor gene variants and risk of perinatal depression
... Past history of depression and family history of mental illness remain the two strongest predictors of perinatal depression [21]. Given the role of the hypothalamic- pituitary-adrenocortical (HPA) axis in the aetiology ...
6
Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection
... the glucocorticoid receptor ...the GR. In Cav1 knockout mice GR transactivates anti-inflammatory genes, including Dusp1, more than in ...tested GR/Cav1 crosstalk in a model of allergic ...
13
Rational ligand based drug design and structure activity relationship studies in the ligand binding domain of the glucocorticoid receptor ?
... in glucocorticoid receptor (GR) drug design efforts towards the determination of novel GR ...the GR. Future trends towards integrated GR ligand design incorporating ligand- and ...
17
The Glucocorticoid Receptor (GR) Stimulates Herpes Simplex Virus 1 Productive Infection, in Part Because the Infected Cell Protein 0 (ICP0) Promoter Is Cooperatively Transactivated by the GR and Krüppel-Like Transcription Factor 15
... the glucocorticoid receptor (GR), a pioneer transcription ...the GR can stimulate productive infection and viral gene ...the GR-specific antagonist (CORT-108297) significantly reduced ...
12
Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
... human glucocorticoid receptor (hGR) pre-mRNA generates two highly homologous isoforms, termed hGR alpha and hGR ...of glucocorticoid-responsive genes by binding to specific glucocorticoid ...
8
Glucocorticoid receptor knockdown and adult hippocampal neurogenesis
... that GR is involved in later stages of neurogenesis. GR knockdown in NPCs resulted in accelerated ...that GR in NPCs controls correct positioning of NPCs as well a physiological evidence for an ...
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Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis
... the glucocorticoid (GC) concentration, the ultimate biological effects of GCs are also determined by an individual’s GC ...the GR. Population studies identified several polymorphisms in the GR gene, ...
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A mutation of the glucocorticoid receptor in primary cortisol resistance
... The precise molecular abnormalities that cause primary cortisol resistance have not been completely described. In a subject with primary cortisol resistance we have observed glucocorticoid receptors (hGR) with a ...
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Ex vivo stimulation of whole blood as a means to determine glucocorticoid sensitivity
... reaction; gR, glucocorticoid receptor; gIlZ, glucocorticoid inducible leucine zipper; FKBP51, FK506 binding protein 51; FlAP, arachidonate 5-lipoxygenase-activating protein; MKP- 1, mitogen ...
9
A Comparative Analysis of Free-Range vs. Caged Layer Hens: Egg Productivity & Quality, Humoral Immunocompetency, & Follicular Expression of Glucocorticoid Receptors.
... Thus, a comprehensive examination of ovarian corticosterone susceptibility through examination of differences in glucocorticoid receptor (GR) expression in the ovarian follicles[r] ...
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Impact of Early Environment on Children's Mental Health: Lessons From DNA Methylation Studies With Monozygotic Twins
... Indeed, following the demonstration of DNA methylation changes in the hip- pocampal glucocorticoid receptor (GR) gene promoter fol- lowing environmental stressors in rats (Weaver et al.,[r] ...
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Glucocorticoid mediated Specific Regulation of Calcium Channel: An in silico study
... respect. Glucocorticoid confers its activity by precise and specific regulation of certain ...its receptor in the cytosol and translocates to the nucleus and hereby activates or represses particular ...
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