glucocorticoid receptor(s)
Human small cell lung cancer cell lines expressing the proopiomelanocortin gene have aberrant glucocorticoid receptor function
... the glucocorticoid receptor (GR) in the SCLC cell line COR L24 using a whole cell ligand binding assay (Kd = ...(TRE)3-tkCAT), glucocorticoid-regulated reporter gene constructs were transfected into ...
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Expression of Glucocorticoid Receptor Isoforms (a, β, γ, and p) in Egyptian Primary Immune Thrombocytopenia Patients
... of glucocorticoid receptors ...determining glucocorticoid receptor (GR) isoforms expression in adult ITP and its relation to glucocorticoid ...included. Glucocorticoid Receptor ...
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Glucocorticoid Receptor Nuclear Translocation in CD4 T Cells from Severe and Moderate Asthmatic Patients Treated with Fluticasone/Vilanterol
... I. Glucocorticoid Receptor (GR) translocation was increased in CD4 T cells after treatment with fluticasone furoate (FF), vilanterol (V) and Fluticasone furoate /vilanterol (FF/V) for one hour in control ...
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Glucocorticoid receptor polymorphism in obesity and glucose homeostasis
... Glucocorticoid receptor (GR) activity plays a significant role in the etiology of obesity and is essential for glucose homeostasis, the development of hyperinsulinaemia and subsequent increased fat ...
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Unraveling the glucocorticoid receptor pathway in zebrafish
... The glucocorticoid receptor (GR) is expressed almost ubiquitously in the human body and regulates a wide range of biological processes such as our metabolism, growth, reproduction, vascular tone, bone ...
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Regulation of triglyceride metabolism by glucocorticoid receptor
... intracellular receptor, the glucocorticoid receptor ...genomic glucocorticoid response ele- ments (GRE) to modulate the transcription of nearby genes (called GR primary target genes), which in ...
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Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
... human glucocorticoid receptor (hGR) pre-mRNA generates two highly homologous isoforms, termed hGR alpha and hGR ...of glucocorticoid-responsive genes by binding to specific glucocorticoid ...
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Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection
... Glucocorticoids (Gcs) are widely prescribed anti-inflammatory compounds, which act through the glucocorticoid receptor (GR). Using an unbiased proteomics screen in lung tissue, we identified the membrane ...
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Rational ligand based drug design and structure activity relationship studies in the ligand binding domain of the glucocorticoid receptor ?
... The interest in developing synthetic glucocorticoids (GCs) arises from the utility of endogenous steroids as potent anti-inflammatory and immunosuppressant agents. The first GCs to be discovered, such as cortisol or ...
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Glucocorticoid receptor gene polymorphism and juvenile idiopathic arthritis
... intracellular glucocorticoid receptor- a (GR- a ...with glucocorticoid-responsive ele- ments of different ...enhancing glucocorticoid receptor expression in the cytoplasm ...
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Case control study of glucocorticoid receptor and corticotrophin releasing hormone receptor gene variants and risk of perinatal depression
... Past history of depression and family history of mental illness remain the two strongest predictors of perinatal depression [21]. Given the role of the hypothalamic- pituitary-adrenocortical (HPA) axis in the aetiology ...
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Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis
... All analyses with regard to the differences between cases and controls were performed using a binary logistic regression model. Crude odd ratios (OR), as estimates of the relative risks, were calculated with 95% ...
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<p>Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD</p>
... fl’ s actions, including whether and how such signaling is altered, will inform about the molecular mechanism of GR α downregula- tion and thereby glucocorticoid resistance in ...
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A mutation of the glucocorticoid receptor in primary cortisol resistance
... The precise molecular abnormalities that cause primary cortisol resistance have not been completely described. In a subject with primary cortisol resistance we have observed glucocorticoid receptors (hGR) with a ...
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Glucocorticoid receptor knockdown and adult hippocampal neurogenesis
... 1.2.2, glucocorticoid binding to GR can induce cellular changes through dimerization-dependent and independent ...the receptor to the DNA, but able to indirectly influence gene transcription by modulation ...
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The glucocorticoid receptor and cortisol levels in pediatric septic shock
... We have shown differential expression of two of the major glucocorticoid signaling molecules—cortisol and GCR alpha—in critically ill children. The finding of low expres- sion of GCR in patients with a complicated ...
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LPS regulates the expression of glucocorticoid receptor α and β isoforms and induces a selective glucocorticoid resistance in vitro
... The GC actions are mediated through the activation of intracellular glucocorticoid receptors (GR) . The genomic structure of the single GR gene described in humans consists of 9 exons. Alternative splicing of exon ...
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A Comparative Analysis of Free-Range vs. Caged Layer Hens: Egg Productivity & Quality, Humoral Immunocompetency, & Follicular Expression of Glucocorticoid Receptors.
... Thus, a comprehensive examination of ovarian corticosterone susceptibility through examination of differences in glucocorticoid receptor (GR) expression in the ovarian follicles[r] ...
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Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids
... underlie glucocorticoid insufficiency in sepsis and the molecular action of ...to glucocorticoid insufficiency, including drugs, coagulation disorders and inflammatory ...impair glucocorticoid access ...
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Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations
... of glucocorticoid feedback resistance, a central feature in CD that allows tumors to escape the physiological regulatory mechanisms, through the identification of the interaction of the glucocorticoid ...
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