Glucose-dependent insulinotropic polypeptide (GIP)
Glucose dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice
... meal. Glucose-dependent insulinotropic polypeptide (GIP) represents a suitable candidate in mediating this ...of GIP signaling on trabecular bone volume, microarchitecture and ...
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Fehlings, Christiane (2010): Physiological and morphological characterization of trangenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn): a large animal model of diabetes research. Dissertation, LMU München: Tierärztliche Fakultät
... the insulinotropic action of both incretins revealed that the insulinotropic action of GIP was markedly impaired, while this of GLP-1 was preserved in type 2 diabetic patients (Nauck et ...the ...
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Renner, Simone (2008): Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor: a novel animal model for studying the consequences of impaired incretin hormone function. Dissertation, LMU München: Tierärztliche Fakultät
... supraphysiological GIP levels leads to partial binding of GIP to the GLP-1 receptor that is intact in GIPR dn transgenic pigs resulting in additional insulin secretion following GIP + glucose ...
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Streckel, Elisabeth Therese (2013): Effects of the long-acting glucagon-like peptide-1 receptor agonist liraglutide in adolescent pigs with impaired glucose-dependent insulinotropic polypeptide receptor function. Dissertation, LMU München: Tierärztliche Fakultät
... 1999) GIP can bind to the GIPR dn with almost equal affinity as it has to the endogenous GIPR, but the binding does not provoke any further biological functions (Herbach et ...ligand GIP a reduction of the ...
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Effects of glucose dependent insulinotropic polypeptide on gastric emptying, glycaemia and insulinaemia during critical illness: a prospective, double blind, randomised, crossover study
... of GIP on nutrient absorption in the critic- ally ill was of particular ...interest. Glucose absorption is markedly diminished in the critically ill patient and downregulation of the sodium–glucose ...
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Herbach, Nadja (2002): Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn). Dissertation, LMU München: Tierärztliche Fakultät
... that GIP is a secretagogue for GLP-1. In contrast, exogenous GIP does not lead to an increment in plasma GLP-1 in ...elevated glucose levels and enhances proinsulin gene expression (Fehmann HWDO ...
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Postprandial stimulation of insulin release by glucose dependent insulinotropic polypeptide (GIP) Effect of a specific glucose dependent insulinotropic polypeptide receptor antagonist in the rat
... both GIP and GLP-1 possess significant insulino- tropic properties, controversy exists regarding their relative physiological roles in stimulating insulin ...that GIP and GLP-1 are equally potent in their ...
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Do incretins improve endothelial function?
... the glucose-dependent stimula- tion of insulin secretion by pancreatic ...and glucose-dependent insulinotropic polypeptide (GIP), de- rived from the K-cells of the ...
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Dual elimination of the glucagon and GLP 1 receptors in mice reveals plasticity in the incretin axis
... incretin glucose-dependent insulinotropic polypeptide (GIP), mice lacking both Glp1r and the GIP receptor (Gipr) maintained preservation of the enteroinsular axis following ...
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The intestinal distribution pattern of appetite and glucose regulatory peptides in mice, rats and pigs
... and glucose regulatory peptides: glucose-dependent insulinotropic polypeptide (GIP), glucagon- like peptide-1 (GLP-1), glucagon-like peptide-1 (GLP-2), oxyntomodulin/glicentin, ...
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df892bc907f6cb09a7963bbe4632eaf49d6addd9.pdf
... Central GIP signaling stimulates peripheral GIP release and promotes insulin and pancreatic polypeptide secretion in nonhuman ...doi:10.1152/ajpendo.00166.2016.—Glucose- dependent ...
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Adrenal GIPR expression and chromosome 19q13 microduplications in GIP-dependent Cushing’s syndrome
... Adrenal glucose-dependent insulinotropic polypeptide receptor (GIPR) expression in patients with GIP-dependent Cushing’s syndrome or ...to GIP were ...with GIP- ...
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Study on Quantitative Assessment of Insulin Response in Impaired Glucose Regulation
... of glucose (AUCg) during OGTT for discrimination of various degrees of glucose ...impaired glucose regulation group making it ...OGTT glucose concentrations along with the values of insulin ...
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Effect of dipeptidyl-peptidase-4 inhibitors on C-reactive protein in patients with type 2 diabetes: a systematic review and meta-analysis
... emerging glucose-lowering agents through interacting with DPP-4 substrate, impact of which on systemic inflammation in type 2 diabetes mellitus (T2DM) remains ...
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PAC1 receptor–deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance
... blood glucose (the major initiator) and incom- ing potentiators such as other nutrients, hormones, and neurotransmitters from the autonomic innervation ...cyclase–activating polypeptide (PACAP), a member of ...
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A CRITICAL REVIEW ON POTENTIAL PHARMACOLOGICAL AND PHYTOCHEMICAL PROPERTIES OF GYMNEMA SYLVESTRE R. Br.
... dose dependent inhibition ofα-glucosidase that was found to be comparable to ...additional glucose unit in the former facilitated stronger hydrogen bonding at the ...
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Metformin Modulates GLP 1 and GIP Mediated Intracellular Signaling under Normoglycemic Conditions
... Effects of Metformin on GLP-1- and GIP-Induced Insulin Secretion Treatment with 10 nM GLP-1 or GIP enhanced insulin secretion in the presence of 5.5 mM glucose Figure 3, whereas 2 h-pret[r] ...
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Preserved incretin activity of glucagon like peptide 1 [7 36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type 2 diabetes mellitus
... oral glucose with the low, and clearly supraphysiological with the high infusion ...Both GIP and GLP-1 [7-36 amide] dose- dependently augmented insulin secretion (insulin, C-peptide) in both groups (P < ...
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Early metabolic predictors for the development of Type 2 diabetes in 1st degree relatives. Results of a 10-year follow-up study (1984-1994), together with cross-sectional analyses in 1994.
... amyloid polypeptide (lAPP) (Cooper et a/,1987; Westermark et a/,1987) by a process of oligomerisation of lAPP molecules as a result of diabetes-related conditions which are yet to be ...and glucose ...
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Is there a justification for classifying GLP-1 receptor agonists as basal and prandial?
... In contrast to most previous recommendations on the treatment of patients with type 2 diabetes, which were generally aimed at harmonizing and reducing variabil- ity in clinical practice, current guidelines advocate an ...
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