Glucose-induced insulin secretion
Glycated albumin suppresses glucose-induced insulin secretion by impairing glucose metabolism in rat pancreatic β-cells
... Results: Insulin secretion in the presence of HA and GA was ...of insulin secretion by ...of insulin secretion. Conclusion: GA suppresses glucose-induced ...
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Impairment of glucose induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice
... normoglycemia regained a normal graft insulin content, but a decreased insulin response to glucose remained. No ultrastructural signs of beta-cell damage were observed, with the exception of ...
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The Glucose Receptor A DEFECTIVE MECHANISM IN DIABETES MELLITUS DISTINCT FROM THE BETA ADRENERGIC RECEPTOR
... serum insulin responses in 10 normal subjects after rapid intravenous injection of glucose (5 g) or isoproterenol (2 µg) were of similar magnitude and timing (glucose: 431±349%; mean Δ3-5¢ ...
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Alterations in basal and glucose stimulated voltage dependent Ca2+ channel activities in pancreatic beta cells of non insulin dependent diabetes mellitus GK rats
... of insulin secretion to nonglucose depolarizing stimuli observed in NIDDM beta cells could be the result, therefore, of increased voltage-dependent Ca2+ channel ...by glucose is markedly less ...
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Pancreatic β- and α-cell adaptation in response to metabolic changes
... is insulin resistance. In chapters 2 – 4 we show that insulin resistance is associated with an increased β-cell mass in different ...diet induced insulin resistance in mice led to an increased ...
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Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT T15
... the glucose toxic effect induced by prolonged culturing of HIT cells in supra- physiologic concentration of glucose is not only preventable by culturing these cells in a low concentration of ...
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[6] Gingerol, from Zingiber officinale, potentiates GLP 1 mediated glucose stimulated insulin secretion pathway in pancreatic β cells and increases RAB8/RAB10 regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice
... Glucose-induced insulin secretion could be amplified by various extracellular stimuli such as gastrointestinal hormones ...the insulin secretagogue activity of ...the ...
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In vitro insulin secretion by pancreatic tissue from infants with diazoxide resistant congenital hyperinsulinism deviates from model predictions
... between insulin secretion in vitro and in vivo. Insulin secretion has been studied in CHI infants before surgery, gener- ally in an attempt to distinguish between FoCHI and ...state ...
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A unique control mechanism in the regulation of insulin secretion Secretagogue induced somatostatin receptor recruitment
... inhibit insulin release. Islets were perifused with glucose (30, 100, 165, 200, or 300 mg/dl) in the presence of sodium ...inhibits insulin release, but not the recruitment of SRIF ...as ...
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Triterpenoid Saponin from Momordica tuberosa (Cucurbitaceae) Stimulates Insulin Secretion from Isolated Mouse Pancreatic Islets and Provides Protection from Streptozotocin and High-Glucose Induced Injury
... lin secretion from the islets, provided protection from STZ-induced cytotoxicity and oxidative stress and also from that of experimental high glucose-induced toxic- ity that mimics the ...
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Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
... normal glucose-tolerant individuals with a first-degree relative with diabetes received small doses of cortisone acetate, oral glucose tolerance test- ing revealed that 24% had IGT and 19% had ...of ...
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Castration-induced testosterone deficiency increases fasting glucose associated with hepatic and extra-hepatic insulin resistance in adult male rats
... baseline insulin concentrations in castrated rats were higher than those in normal rats, which conformed to the results in non-diabetic men ...However, glucose-stimulated insulin secretion ...
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Metformin Modulates GLP 1 and GIP Mediated Intracellular Signaling under Normoglycemic Conditions
... Effects of Metformin on GLP-1- and GIP-Induced Insulin Secretion Treatment with 10 nM GLP-1 or GIP enhanced insulin secretion in the presence of 5.5 mM glucose Figure 3, whereas 2 h-pret[r] ...
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Management of Type 2 Diabetes Mellitus by DPP-IV Inhibition – A Review
... meal induced, glucose-dependent insulin secretion (incretin effect) and restores glucose competency to the β -cells of pancreas including the delay of gastric emptying and suppression ...
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Path Analysis on the Effects of Bio-psychosocial Factors and Calorie Intake in Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
... blood glucose level control is determined more on the activating of insulin receptor by doing diet and physical activity/ exercise as well as quit smoking (Bilous and Donelly, ...
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Insulin induced hypoglycemia stimulates corticotropin releasing factor and arginine vasopressin secretion into hypophysial portal blood of conscious, unrestrained rams
... (AVP) secretion in hypophysial portal blood (HPB) during IIH have been diversely ...the secretion of CRF and AVP in HPB and on the release of ACTH and cortisol in peripheral plasma in conscious, ...
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The dipeptidyl peptidase-4 inhibitor may improve the insulin secretion in type 2 diabetes patients just after starting hemodialysis treatment: preliminary study
... Our study has several limitations, such as the small number of patients and performed in the incident hemodialysis inpatients. In this phase, uremia, anemia, malnutrition, CKD-MBD, and acidosis affect impaired ...
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Diabetes in dogs and cats: an update
... Fructosamines are proteins to which glucose has been irreversibly and non-enzymatically bound. Serum fructosamine concentration gives an indication of the mean blood glucose concentration over the last ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... in insulin-stimulated signaling ...oral glucose tolerance test and a negative family history of diabetes were ...in insulin secretion capacity (estimated by insulin responses in an oral ...
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24 hour glucose profiles during continuous or oscillatory insulin infusion Demonstration of the functional significance of ultradian insulin oscillations
... Serum insulin levels tended to be lower during oscillatory than constant infusion, although the same amount of exogenous insulin was administered under both ...Ultradian insulin oscillations appear ...
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