glucose-regulated protein
Glucose regulated protein 78 demonstrates antiviral effects but is more suitable for hepatocellular carcinoma prevention in hepatitis B
... Glucose-regulated protein 78 (GRP78/BiP) constitutively expresses in the ...ER-associated protein degradation, and serving as the ER stress sensor to release cells from the stress conditions ...
9
Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells
... Glucose-regulated protein 78(GRP78) is present at a basal level in normal tissues. However it is overex- pressed in almost all the human cancers and plays important role in anti-apoptotic process of ...
12
Astragalus saponins modulates colon cancer development by regulating calpain mediated glucose regulated protein expression
... transmembrane protein synthesis, folding and maturation ...unfolded protein response (UPR) to prevent apoptosis ...CCAAT/enhancer-binding protein-homologous protein (CHOP), pro-apoptotic Bcl-2 ...
12
Glucose-Regulated Protein 94 (GRP94): A novel regulator of insulin-like growth factor production
... As primary drivers of growth and proliferation at the somatic, tissue and cellular levels, the insulin-like growth factors (IGFs) must have tightly regulated activity – in terms of amount, timing, and spatial ...
14
Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided <sup>111</sup>In-labeled polymeric micelles
... Abstract: Increased expression of cellular membrane bound glucose-regulated protein 78 (GRP78) is considered to be one of the biomarkers for gastric cancers. Therefore, peptides or molecules with ...
7
Original Article Association between glucose-regulated protein and neutrophil apoptosis in severe acute pancreatitis
... kDa glucose regulated protein is a stress protein and its expression increases significantly following stress to maintain the stability of endoplasmic reticulum and protect cells ...
7
Original Article Expression of glucose regulated protein 78 in human triple negative breast cancer and its clinical implications
... The glucose regulated protein 78 (GRP78, also known as BiP and HSPA5) and GRP94 (also known as GP96 and HSP90B1) are stress- inducible molecular ...in protein folding and assembly, retrograde ...
9
High expression of glucose-regulated protein 78 (GRP78) is associated with metastasis and poor prognosis in patients with esophageal squamous cell carcinoma
... Background: Glucose-regulated protein 78 (GRP78) plays an important role in the invasion and metastasis of many human ...this protein in the progression of invasion and metastasis in ...
9
Glucose regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance
... with either lymphatic metastasis or distant metastasis was higher than that in patients without metastasis, and there was a significant positive correlation between the expression of HPA and GRP78. In the present study, ...
8
The 78 kDa glucose regulated protein (GRP78) as a potential treatment predictive biomarker and therapeutic target in colorectal cancer adjuvant chemotherapy
... binding protein 1 ...XBP1 protein isoform of 376 amino acids as a result of a frameshift in the fully-spliced mRNA (XBP1s) and this longer XBP1 protein is a potent transcriptional activator of UPR ...
275
Identification of the N-terminal Peptide Binding Site of Glucose-regulated Protein 94
... position helix 4, an important portion of the binding pocket (22, 23, 26). The D93N mutant of HSP90 does not bind ATP (27), so the double mutant of GRP94 was expected to be unable to bind radicicol. Recombinant N34 –355 ...
11
Therapeutic Potential of Glucose Regulated Protein 78 in Cancer
... Developmental oncoprotein Cripto binds to cell surface GRP78 and promotes prosurvival signaling via MAPK/PI3K and Smad2/3 pathways. Cripto-dependent increase in cellular proliferation is prevented by immuno- ...
6
Human telomerase reverse transcriptase and glucose regulated protein 78 increase the life span of articular chondrocytes and their repair potential
... hTERT is a candidate gene for gene therapy of muscu- lar dystrophy [31-34]. In contrast, GRP78 may have ther- apeutic applications for neuropathological conditions, such as Alzheimer’s disease, because it protects cells ...
10
Restraint Induced Expression of Endoplasmic Reticulum Stress Related Genes in the Mouse Brain
... 94-kilodalton glucose regulated protein, EDEM: ER degradation-enhancing α-mannosidase-like protein, p58IPK: protein kinase inhibi- tor of 58 kilodalton, ASNS: asparagines synthetase, ...
7
Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma
... unfolded protein response (UPR) ...chaperone glucose- regulated protein, 78 kDa (GRP78), PERK phosphorylates eukaryotic initiation factor 2α (eIF2α) leading to repression of global ...in ...
13
The HLA B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients
... lipoxygenase-activating protein; ATF4: activating transcription factor 4; BiP/ GRP78: glucose regulated protein; C1QC/C1QB: complement component 1, q subcomponent, C / B chain; CDKN1A: ...
10
Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation
... pro-apoptotic protein for ER stress activated cell death is CHOP, whose expression level is sub- stantially stimulated by activation of the PERK and ATF6 branches of the UPR [33, ...
10
Analysis of the Protein Kinase A Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin Proteasome Pathway in Capsule Formation
... part regulated by the cyclic-AMP/ protein kinase A (cAMP/PKA) signal transduction ...and protein degradation in chronic neurodegenerative disorders and other human ...
15
Role of Glucose in the Expression of Cryptococcus neoformans Antiphagocytic Protein 1, App1
... low glucose concentrations ...versus glucose (compare ...during glucose starva- tion are also upregulated during galactose starvation ...during glucose starvation may be more similar to that ...
9
Neuroendocrine regulation of feeding behaviour
... related protein was discovered as an endogenously released neuropeptide that acts as an inverse agonist for the melanocortin receptors, MC3R/MC4. AgRP is co-expressed in hunger activated neurons with NPY, another ...
5