glucose regulated protein 78
Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided <sup>111</sup>In-labeled polymeric micelles
... Abstract: Increased expression of cellular membrane bound glucose-regulated protein 78 (GRP78) is considered to be one of the biomarkers for gastric cancers. Therefore, peptides or molecules ...
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Glucose regulated protein 78 demonstrates antiviral effects but is more suitable for hepatocellular carcinoma prevention in hepatitis B
... Glucose-regulated protein 78 (GRP78/BiP) constitutively expresses in the ...ER-associated protein degradation, and serving as the ER stress sensor to release cells from the stress ...
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High expression of glucose-regulated protein 78 (GRP78) is associated with metastasis and poor prognosis in patients with esophageal squamous cell carcinoma
... Background: Glucose-regulated protein 78 (GRP78) plays an important role in the invasion and metastasis of many human ...this protein in the progression of invasion and metastasis in ...
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Original Article Expression of glucose regulated protein 78 in human triple negative breast cancer and its clinical implications
... that glucose regulated protein 78 (GRP78) may predict survival and respon- siveness to chemotherapy or endocrine therapy in breast ...another glucose regulated ...
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Inhibition of endoplasmic reticulum chaperone protein glucose- regulated protein 78 potentiates anti-angiogenic therapy in renal cell carcinoma through inactivation of the PERK/eIF2α pathway
... chaperone glucose-regulated protein 78 (GRP78), also known as immunoglobulin heavy-chain-binding protein (BiP) ...of protein synthesis by forming a ternary complex with GTP and ...
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Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells
... Glucose-regulated protein 78(GRP78) is present at a basal level in normal tissues. However it is overex- pressed in almost all the human cancers and plays important role in anti-apoptotic ...
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Experimental study of inhibitory effects of diallyl trisulfide on the growth of human osteosarcoma Saos-2 cells by downregulating expression of glucose-regulated protein 78
... Background: Diallyl trisulfide (DATS) is a natural organic sulfur compound isolated from garlic that has good anticancer activity according to many previous reports. There are many studies pointing out that DATS can ...
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Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device
... significantly lower than those of control cells. We also found that both number and distance of SPCA-1 cell invasion were less than those of A549 cells, indicating that the migratory capacity of varying tumor cells ...
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Therapeutic Potential of Glucose Regulated Protein 78 in Cancer
... up- regulated in colon cancer tissue but not in normal ...the protein level, but there was no difference in the relative mRNA expression levels [49, ...
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Human telomerase reverse transcriptase and glucose regulated protein 78 increase the life span of articular chondrocytes and their repair potential
... hTERT is a candidate gene for gene therapy of muscu- lar dystrophy [31-34]. In contrast, GRP78 may have ther- apeutic applications for neuropathological conditions, such as Alzheimer’s disease, because it protects cells ...
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Glucose regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance
... with either lymphatic metastasis or distant metastasis was higher than that in patients without metastasis, and there was a significant positive correlation between the expression of HPA and GRP78. In the present study, ...
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Original Article Association between glucose-regulated protein and neutrophil apoptosis in severe acute pancreatitis
... of glucose regulated protein 78 (GRP-78) in the apop- tosis of neutrophils in rats with severe acute ...the protein expression of GRP-78 and Mcl-1 increased in neutrophils ...
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The differential expressions of 78 kDa glucose regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis
... Synovium and synovial fluid were taken at total knee arthro- plasty or arthroscopic synovectomy for the inflammatory peripheral joints in Xijing Hospital from 24 RA patients (7 males and 17 females). All of the RA ...
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Potassium-3-beta-hydroxy-20-oxopregn-5-en-17-alpha-yl sulfate: a novel inhibitor of 78 kDa glucose-regulated protein
... Notes: (A) cells were pretreated with PhOs for 24 hours before the whole cell lysates (30 µg) were subjected to Western blot analysis. Western blot analysis of glyceraldehyde-3-phosphate dehydrogenase (gaPDh) levels was ...
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Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling Glucose regulatory protein 78 and AMPK
... Our next step was to investigate the molecular mechanism behind DIM induced autophagy. Recent literature suggests that disturbances in the integrity of ER activate autophagy [6]. Hence, we questioned ourselves whether ...
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The 78 kDa glucose regulated protein (GRP78) as a potential treatment predictive biomarker and therapeutic target in colorectal cancer adjuvant chemotherapy
... promote glucose influx to cancer cells via increased transcription of type II hexokinase, an enzyme that converts glucose to glucose-6-phosphate, the initial step in ...
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Original Article Increased expression of 78 kD glucose-regulated protein promotes cardiomyocyte apoptosis in a rat model of liver cirrhosis
... CCAAT/enhancer-binding protein homologous protein (CHOP) is another important signaling molecule of ER stress, which play an important role in promoting apoptosis through the regula- tion of B cell ...
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Structural and Functional Features of a Developmentally Regulated Lipopolysaccharide Binding Protein
... The regulation of lbp gene expression by TCT and not LPS was unexpected, given that in mammalian systems, LPS increases lbp expression (43, 44); we are not aware of experiments showing the effect of peptidoglycan ...
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Environmentally Regulated Glycosome Protein Composition in the African Trypanosome
... glycosome protein expression under standard culturing ...of glucose, the mis- localization of glycosome proteins is less detrimental to the para- sites, and we reasoned that under these conditions, cells of ...
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A Novel Approach to Facile Synthesis and Biosensing of the Protein-Regulated Graphene
... When bovine serum albumin (BSA), a protein with isoelectric point at 4.5 pH, that possess hydrophobic and hydrophilic amino acids, was ultrasounded, the layer exfoliation was beginning. The role of BSA in the ...
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