glutamate receptor
Opioid antinociception and antihyperalgesia in combination with metabotropic glutamate receptor antagonism
... of glutamate receptors is particularly interesting in this ...metabotropic glutamate receptor subtypes 1 (mGluR1) and 5 (mGluR5) are post-synaptic receptors which are highly expressed in areas of the ...
52
Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction
... the glutamate receptor complex? In many systems, proteins containing the PDZ domain play important anchoring and struc- tural roles in synapse organization (Hung and Sheng, ...this receptor to the ...
11
Association of metabotropic glutamate receptor 3 gene polymorphisms with schizophrenia risk: evidence from a meta-analysis
... Systematic searches of the PubMed database (to November 2, 2014) were performed using the search terms: “GRM3”, “metabotropic glutamate receptor 3”, “polymorphism”, “SNP”, “variant”, and “schizophrenia”. ...
11
Interactions between opioid agonists and glutamate receptor antagonists
... mGlu receptor antagonists with opioids that are lower in efficacy for the treatment of pain may also arise from the results of Experiment 1 and ...mGlu receptor antagonists increase the efficacy of ...
131
An investigation of the metabotropic glutamate receptor of hippocampal neurones with flash photolysis
... f glutamate, was shown to enhance the hydrolysis o f membrane ...novel glutamate receptor was found. The receptor had a high affinity for quisqualate and directly activated inositol phosphate ...
215
Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization
... (9) Monn, J. A.; Prieto, L.; Taboada, L.; Pedregal, C.; Hao, J.; Reinhard, M. R.; Henry, S. S.; Goldsmith, P. J.; Beadle, C. D.; Walton, L.; Man, T.; Rudyk, H.; Clark, B.; Tupper, D.; Baker, S. R.; Lamas, C.; Montero, ...
11
Impact of allosteric modulation: exploring the binding kinetics of glutamate and other orthosteric ligands of the metabotropic glutamate receptor 2
... [36] J.A. Monn, L. Prieto, L. Taboada, C. Pedregal, J. Hao, M.R. Reinhard, S.S. Henry, P.J. Goldsmith, C.D. Beadle, L. Walton, T. Man, H. Rudyk, B. Clark, D. Tupper, S.R. Baker, C. Lamas, C. Montero, A. Marcos, J. ...
10
Metabotropic glutamate receptor 5 may be involved in macrophage plasticity
... and glutamate on NO and IL‑10 secretion To clarify the role of mGluR5 in the activity of mac- rophages, we conducted mGluR5 gene transfection in the murine ...and glutamate treatments ...of glutamate ...
9
Rapid glutamate receptor 2 trafficking during retinal degeneration
... In normal tissues, differential expression of GluRs by bipolar cells creates parallel ON and OFF channels in vision. ON bipolar cells express mGluR6 receptors while OFF bipolar cells express either AMPA or KA receptors. ...
14
Metabotropic glutamate receptor mediated modulation of N-methyl-D-aspartate (NMDA) receptor-channels in the rat hippocampus
... A great deal of attention has focused on protein kinase C (PKC) as a modulator of NMDA mediated responses due to its abundance in the CNS (Brandt, et aL, 1987) and also its ability to readily phosphorylate other ion ...
168
Regulation of Akt and Wnt signalling by the dopamine D2 receptor and metabotropic glutamate receptor 2/3
... Converging lines of research have implicated Group II metabotropic glutamate receptors (mGluR2 and mGluR3) in schizophrenia and as a potential new therapeutic target to treat the symptoms of schizophrenia. ...
191
Enhancement of desensitization of quisqualate type glutamate receptor by the dissociative anaesthetic ketamine
... When ketamine was now applied to the preparation the amplitude of the first response in a train was reduced compared with that in a concanavalin-A-treated control train as occurred in th[r] ...
14
Identification of novel modulators for ionotropic glutamate receptor, iGluA2 by in-silico screening
... The known positive AMPA receptor modulators fall into three structural classes, namely: 1) pyrrolidinone and related piperidine compounds (e.g., aniracetam, CX614, CX516, CX516), 2) benzothiadiazide derivatives ...
11
The investigation of the antiparkinsonian effects of glutamate receptor antagonists
... f glutamate antagonists in drug-naive and reserpine-treated m ...the glutamate release blockers, lamotrigine and clonidine, the glycine site antagonist, (±) H A -966 and the com petitive N M D A antagonist, ...
241
Regulation of Metabotropic Glutamate Receptor 5 activity by Ca2+/Calmodulin-dependent Protein Kinase IIα
... the receptor that allows GDP to be exchanged for GTP on the α subunit of the heterotrimeric GTP- binding protein (G protein), subsequently leading to the disassociation of the α subunit from the receptor ...
83
Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
... by glutamate receptor agonists including glutamate, N-methyl-D-aspartate (NMDA), and metabotropic glutamate 5 receptor (mGluR5) activator (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), as ...
10
N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis
... ionotropic glutamate receptor subunits, both at the mRNA and protein ...express glutamate transporters VGLUT1 and 2. The de- tected glutamate concentrations (2–10 nmol/mL) are in a good ...
19
‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII
... metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ...
22
Download Download PDF
... non-NMDA glutamate receptor subunits in the rat red ...GluN2A) receptor subunits. The results showed that all ionotropic glutamate receptor subunits are expressed in the red ...
9
Smelling the difference: controversial ideas in insect olfaction
... ionotropic glutamate receptor family (iGluRs); therefore, adding one more dimension to the role of ion channels in the olfactory system (Benton et ...multiple receptor families can be recruited to ...
7