Glutamate receptors and the brain
Chronic nicotine treatment differentially modifies acute nicotine and alcohol actions on GABA A and glutamate receptors in hippocampal brain slices
... AMPA receptors, the ethanol blockade of the nicotine potentiation of both NMDA and AMPA receptor EPSCs is likely to be due to the inhibition of presynaptic ...
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Activation of presynaptic ionotropic glutamate receptors stimulates gaba release from hippocampal and cortical rat brain nerve terminals
... presynaptic glutamate receptor activation in the regulation of inhibitory synaptic transmission in the rat hippocampus and ...ionotropic glutamate receptors are involved in the modulation of GABA ...
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Glutamate, Glutamate Receptors, and Downstream Signaling Pathways
... Abstract Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in biosynthetic, bio- ...
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Metabotropic glutamate receptors (mglurs) are coupled
... regional brain and plasma data showed that a 2-tissue-compartment model was superior to a 1-tissue- compartment model, consistent with measurable amounts of both receptor-specific and nonspecific ...the ...
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Metabotropic Glutamate Receptors Molecular Pharmacology
... Introduction Glutamate is the major excitatory neurotransmitter in the ...channel receptors (NMDA, AMPA and kainate receptors) to secure fast synaptic ...1 Glutamate also activates ...
Investigation of the delta subfamily of glutamate receptors by domain transplantation
... the brain is regular and trigeminal neurons arise normally, they start dying at embryonic day 15, coinciding with the terminal dierentiation of motor control circuits in the ...mutant receptors con rms ...
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Glutamate Receptors; From Basic Pharmacology To Clinical Applications
... the brain is of particular interest as it would circumvent any nephrotoxicity associated with the catabolism of high levels of systemic D-serine (Maekawa et ...rat brain (Adage et ...
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Transporter-mediated glutamate homeostasis in the brain
... 5.2 Results 5.2.1 Metabotropic glutamate receptors do not modulate sodium-dependent glutamate transporters by direct interaction with Gpy subunits. All of the experiments described in this chapter ...
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Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology
... 2 receptors both in heterologous cells and in cultured hippocampal neurons ...mouse brain slices ...these receptors in neuronal networks ...binding glutamate to the transmembrane domains ...
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Taste, visceral information and exocrine reflexes with glutamate through umami receptors
... membrane receptors on the tip of specialized taste cells eliciting umami ...tract, glutamate induces functional ...process. Glutamate within the lumen of the stomach stimu- lates afferent fibers and ...
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A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia
... human brain was performed only on the Neuropathology Consor- tium samples by the primer extension combined with denaturing high-performance liquid chromatography (PE- DHPLC) method, according to a previous report ...
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No association between Parkinson disease and autoantibodies against NMDA type glutamate receptors
... Philipps-University, Marburg, Germany. 19 Department of Neurology, RWTH Aachen University, Aachen, Germany. 20 JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and ...
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Metabotropic glutamate receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
... group-I receptors, or within and between group-II and -III receptors ...the brain [422, ...mGlu receptors may be activated by 3,5-DHPG and (S)-3HPG [29] and antagonized by ...
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Contribution of metabotropic glutamate receptors to spinal nociceptive transmission in the rat spinal cord
... in the spinal cord. This study confirm ed that the level o f m G luR m RN A expression in postnatal day 12 rats is sim ilar to that seen in the adult. It also highlighted large changes in mGluR3 and 5 m R N A expression, ...
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Glutamate Receptors and Glioblastoma Multiforme: An Old "Route" for New Perspectives
... 2.2. Glutamate Ion Channels in GBM and Cell Migration Tumor cell migration is a complex event characterized by highly dynamic and coordinated biological processes, comprising cell adhesion and detachment, cell ...
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Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction
... ABSTRACT Glutamate is probably the most important excitatory neurotransmitter in the ...The glutamate N-methyl-D-aspartate receptor (NMDAR) is a calcium-gated channel that coordinates with G protein-coupled ...
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Variant Ionotropic Glutamate Receptors as Chemosensory Receptors in Drosophila
... iGluRs normally function as heterotetrameric assemblies of variable subunit composition that exhibit differing functional properties such as ligand sensitivity and ion permeability. Our analysis indicates that up to five ...
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The role of glutamate transporters in glutamate homeostasis in the brain
... extracellular glutamate concentration, which caused cell ...extracellular glutamate concentration, but caused epileptic-like ...the glutamate concentration low in the extracellular space, whereas ...
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Contributions of metabotropic glutamate receptors to the pathophysiology of autism
... Thus, the proper regulation of protein synthesis in neurons is essential for synaptic plasticity, and disruptions in the signaling pathways that regulate translation will und[r] ...
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Effects of Trimetaphan on Locust Muscle Glutamate Receptors
... (A,B) Intracellular recordings (lower traces) of glutamate potentials resulting from ionophoresis of L-glutamate to a superficial excitatory junction site on locust extensor tibiae muscl[r] ...
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