Glutamic Acid Decarboxylase
Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study
... -aminobutyric acid; GAD: Glutamic acid decarboxylase; GADA: Anti-glutamic acid decarboxylase antibodies; ITF: Infratentorial foci; GMV: Gray matter volume; LMT: The ...
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Antibodies against glutamic acid decarboxylase and indices of insulin resistance and insulin secretion in nondiabetic adults: a cross-sectional study
... Anti-glutamic acid decarboxylase (anti-GAD65) antibodies were measured using a biotin-coupled sandwich ELISA (Kronus, ID, USA, CAT# KR7710), with an analytical sensitivity of ...
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Original Article Increased glutamic acid decarboxylase expression in the hippocampus impairs learning and memory in Fmr1 knockout mice
... of glutamic acid decarboxylase ...amino acid levels of hippocampus by high performance liquid chromatography, the data were analyzed with Multifactor Variance ...γ-aminobutyric acid and ...
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Significant Changes in the Activity of L-Glutamic Acid Decarboxylase of Mouse Hypothalamus After Peripheral Injection of Cholecystokinin-8 and Caerulein
... aminobutyric acid, (GABA), was determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (CCK-8) and caerulein ...L-glutamic acid decarboxylase, (GAD), did not change ...
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Cholinergic endings on various neurons containing calcium binding proteins and glutamic acid decarboxylase in the hippocampus of the rat
... containing glutamic acid decarboxylase (GAD) and calcium binding pro- teins: parvalbumin (PV), calbindin D28k (CB) and calretinin (CR) was conducted on 5 adult rat ...
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The expanding spectrum of pediatric anti-glutamic acid decarboxylase antibody mediated CNS disease - a chance association?
... against glutamic acid decarboxylase ...butyric acid and glycine receptors, and demonstration of intrathecal synthesis of GAD- ab would be ...
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Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type
... Abbreviations used in this paper: BHK, baby hamster kidney; BMI, body mass index; GAD, glutamic acid decarboxylase; ICA, islet cell antibodies; IDDM, insulin-dependent diabetes; ins, ins[r] ...
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Cognitive decline in a patient with anti-glutamic acid decarboxylase autoimmunity; case report
... Glutamic acid decarboxylase (GAD) is the biosynthesiz- ing enzyme of the neurotransmitter g-aminobutyric acid (GABA). Antibodies against GAD cause neurological syndromes[1], including stiff ...
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A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies
... agonist and antagonist muscles triggered by stress, auditory, or tactile stimuli; electromyographic evidence of continuous motor unit activity at rest, and the presence of glutamic acid decarboxylase ...
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Study on the prevalence of glutamic acid decarboxylase antibodies in type 1 diabetic children.
... Eba H. Hathout, MD etal had done a study on prevalence of Autoimmunity, and HLA Characteristics of Children Diagnosed With Type 1 Diabetes Before . The average age of the study patients enrolled was 2.6 years, body mass ...
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Glutamic acid decarboxylase 67 expression by a distinct population of mouse vestibular supporting cells
... Glutamic acid decarboxylase (GAD) catalyzes the conversion of L- glutamic acid to γ -aminobutyric acid (GABA) that in the central nervous system plays a critically important role ...
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Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA DR alleles by T lymphocytes of recent onset IDDM patients
... proteins have been identified as disease targets using patient autoantibodies; more than 80% of prediabetics and most re- cent onset diabetics have autoantibodies directed against the enzyme glutamic acid ...
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The role of anti-glutamic acid decarboxylase autoantibodies in mood disorders
... valproic acid (VPA) in the management of acute manic episodes as well as in the maintenance treatment of other 7 patients with recurrent episodes of manic or manic‑schizoaffective psychosis, irresponsive to ...
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Assessment of the effects of glutamic acid decarboxylase antibodies and trace elements on cognitive performance in older adults
... In the present study, approximately 45% of participants had a normal distribution of cognitive function with 111.2 mean LOTCA-7 score and 55% of participants had abnormal scores of co[r] ...
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Hypercapnic ventilatory response in mice lacking the 65 kDa isoform of Glutamic Acid Decarboxylase (GAD65)
... There are two findings from this group of studies: 1) C57BL/6J mice show a developmental pattern in their ventilatory response to hypercapnia characterized by a smaller relative increase[r] ...
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The Incidence of Glutamic Acid Decarboxylase Autoantibodies and its Association With Clinical Features in Pregnant Women With Gestational Diabetes Mellitus
... All of the GADA positive women who developed type 2 diabetes after delivery (n: 3) had previously used insulin therapy while 3 of 4 GADA negative woman with GDM that were diagnosed wi[r] ...
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Exploring the role of Mycobacterium avium subspecies paratuberculosis in the pathogenesis of type 1 diabetes mellitus: a pilot study
... and glutamic acid decarboxylase (GAD65) and (b) type 1B which is less frequent and has no known ...tyric acid (GABA) by α -decarboxylation of L-glutamic acid ...
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Risk Factors and Primary Prevention Trials for Type 1 Diabetes
... GADA: glutamic acid decarboxylase autoantibody; IAA: insulin auto- antibody; ZnT8A: zinc transporter 8 autoantibody; HLA: human leukocyte antigen; MHC: major histo- compatibility complex; NOD: ...
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Evaluation of subclinical neuropathy in type 1 diabetes mellitus
... The description of type 1 diabetes mellitus (T1DM) was given by Aretaeus in the 2 nd century AD 1 . Type 1 diabetes mellitus is caused by cell mediated autoimmune destruction of - cell in susceptible individuals along ...
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A case report of rigidity and recurrent lower limb myoclonus: progressive encephalomyelitis rigidity and myoclonus syndrome, a chameleon
... Background: Progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome is a rare neurological condition. Its clinical characteristics include axial and limb muscle rigidity, myoclonus, painful spasms and ...
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