glutamine metabolism
Regulation of glutamine metabolism in vitro by bicarbonate ion and pH
... of glutamine-U- 14 C to 14 CO 2 in both slices and mitochondria, an effect comparable to the acute stimulation of glutamine utilization produced by metabolic ...on glutamine metabolism than ...
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Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
... macrophage glutamine and glucose metabolism ...their metabolism and function according to environmental conditions and stimuli in order to polarize for pro- or anti-inflammatory cells ...the ...
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Expression of glutamine metabolism-related proteins in thyroid cancer
... 60. Simpson NE, Tryndyak VP, Pogribna M, Beland FA, Pogribny IP. Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype. ...
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Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations
... phosphorylation. Glutamine is the second primary metabolite to nourish cancer cell ...cells, glutamine becomes essential to the proliferative neoplastic cells and certain cancer cell types become “addicted” ...
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PGC-1α supports glutamine metabolism in breast cancer
... in glutamine metabolism protein levels [see Additional file 5: Figure ...of glutamine metabolism and CAC genes and also reduced forward and reverse CAC fluxes in hypoxia (Figure ...controlling ...
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Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy
... of glutamine metabolism as an anti-tumor target is dependent on the successful development of clinical-grade glutamine metabolism ...inhibit glutamine metabolism using amino acid ...
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Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection
... that glutamine metabolism during the course of infection is regulated ...conditions, glutamine consumption increases until 48 hpi and thereafter decreases to the point that by 72 hpi, con- sumption ...
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Altered glutamine metabolism in platinum resistant ovarian cancer
... in glutamine metabolism such as the amino-acid transporter ASCT-2 and glutaminase (GLS) [7, 8] as well as regulating GLS through post-transcriptional mechanisms by repressing the transcription of miR-23a/b ...
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Renal ammonia and glutamine metabolism during liver insufficiency induced hyperammonemia in the rat
... Renal glutamine uptake and subsequent urinary ammonia excretion could be an important alternative pathway of ammonia disposal from the body during liver failure (diminished urea synthesis), but this pathway has ...
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Coactivator SRC 2–dependent metabolic reprogramming mediates prostate cancer survival and metastasis
... Transcriptional reprogramming supports lipogenesis. To understand the mechanism of SRC-2–depen- dent lipogenesis in prostate cancer cells, we performed targeted gene expression analysis by quantita- tive real-time PCR ...
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Role of glutamine and interlinked asparagine metabolism in vessel formation
... consumed glutamine more than other amino acid ...on glutamine metabolism in ECs, we first characterized the consequences of glutamine deprivation (now utilizing glutamine-free M199 ...
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Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
... So far, most studies on SIRT4 in tumors have been performed on the role of SIRT4 as a tumor suppressor gene. In previ- ous studies, it has been shown that overexpression of SIRT4 in vitro inhibited the proliferation of ...
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PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence
... of glutamine to glutamate, the first step of ...promoting glutamine metabolism ...increasing glutamine consumption correlate with proliferation, migration and invasion of prostate cancer cells ...
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<p>Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake</p>
... the metabolism of cancer cells and enhance the present therapy. Glutamine metabolism is essential for cancer ...biosynthesis. Glutamine acts as a nitrogen donor and a carbon donor, in addition ...
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The effects of acidosis and alkalosis on the metabolism of glutamine and glutamate in renal cortex slices
... on glutamine and glutamate metabolism suggests that either glutamine transport or glutamine transaminase activity are significantly increased by ...
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Anaplerosis in cancer: Another step beyond the warburg effect
... Aerobic glycolysis probably endows cancer cells with the ability to generate biosynthetic intermediates from the glycolytic pathway, thus enabling tumors with the ability to proliferate faster and outnumber their normal ...
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Metabolomics approach by 1H NMR spectroscopy of serum reveals progression axes for asymptomatic hyperuricemia and gout
... acid metabolism, especially circulat- ing metabolites such as high levels of blood BCAAs, are strongly associated with insulin resistance, obesity, diabetes mellitus and cardiovascular disease ...
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Metabonomic profiles delineate potential role of glutamate-glutamine cycle in db/db mice with diabetes-associated cognitive decline
... Nuclear magnetic resonance (NMR)-based metabo- nomic analysis as a systems biology approach aims to de- tect the global metabolic information in biological samples [13, 14]. It has been extensively applied in the ...
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Short Communication: Substrate Utilization by Carp (Cyprinus Carpio) Erythrocytes
... Nucleosides, metabolized via the pentose phosphate pathway, are evidently the Key words: carp erythrocyte, metabolism, lactate, pyruvate, glutamine, glucose, glutamate, aspartate, isoleu[r] ...
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Clinical significance of T cell metabolic reprogramming in cancer
... cellular metabolism can influence epigenetic enzymes by the amount of cofac- tors present in a ...acid metabolism, oxygen sensing, collagen biosynthesis, and modulation of the epigenome ...
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