Glutathione depletion
Glutathione depletion impairs transcriptional activation of heat shock genes in primary cultures of guinea pig gastric mucosal cells
... of glutathione in mediating the initial biochemical events leading to the transcriptional activation of HSP ...intracellular glutathione pool was depleted with BSO before induction of ...intracellular ...
10
Effects of L-glutamic acid and pyridoxine on glutathione depletion and lipid peroxidation generated by epinephrine-induced stress in rats
... duced glutathione (GSh) level, antioxidant enzymes activity and content of the lipid peroxidation products after administration of the above-mentioned substances and under the action of stress in various tissues ...
9
A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose
... that depletion of glutathione is likely to be related to HIV morbidity (typically associated with high viral load, low CD4 count, or the presence of an AIDS defining diagnosis) we would expect that HAART ...
10
In Silico Analysis & In Vivo Results Concur on Glutathione Depletion in Glyphosate Resistant GMO Soy, Advancing a Systems Biology Framework for Safety Assessment of GMOs
... Systems Architecture of Glyphosate Effect and Glutathione Synthesis on Oxidative Stress and C1 Metabolismin GM Soy The literature review of the effect of glyphosate on genetic modificati[r] ...
20
Glutathione Depletion Is Linked with Th2 Polarization in Mice with a Retrovirus-Induced Immunodeficiency Syndrome, Murine AIDS: Role of Proglutathione Molecules as Immunotherapeutics
... GSH depletion and AAM could have an important role in determin- ing the Th2 immune response and that I-152 treatment may rep- resent a useful approach to fight this retroviral infection ...
13
Collateral Sensitivity to Cisplatin in KB 8 5 11 Drug resistant Cancer Cells
... Consequently, glutathione has been shown to be positively correlated with cisplatin resistance in a panel of ovarian cancer cell lines ...of glutathione in response to cisplatin treatment and this trend is ...
18
Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis
... To investigate whether ferroptosis participated in MLE-12 cell death induced by seawater drowning, we pretreated cells with the ferroptosis specific inhibitor Fer-1. MLE-12 cells were treated with Fer-1 at a final ...
16
Intracellular Zinc Release, 12-Lipoxygenase Activation and MAPK Dependent Neuronal and Oligodendroglial Death
... Mitochondria are generally believed to be the major source of ROS generation induced by loss of cellular zinc homeo- stasis. However, recent studies also provide evidence of mitochondria- independent ROS production, such ...
6
A Comparative Study on Serum Levels of Nitric Oxide before and After Initial Periodontal Therapy in Healthy and Type 2 Diabetes Mellitus Patients with Chronic Periodontitis.
... These activities include: lipid peroxidation; glutathione depletion by oxidation; nitrotyrosine formation which may inhibit superoxide dismutase activity; DNA damage by nitrosilation, de[r] ...
130
Depletion of glutathione does not affect electron transport chain complex activities in brain mitochondria: Implications for Parkinsons's disease and postmortem studies
... Glutathione depletion in the pre-weanling rat is a limited model as it may not necessarily reflect the effects of glutathione depletion in the aged or parkinsonian ...brain, depletion ...
23
Antioxidant activity of flavonoids isolated from Dolichos biflorus Linn. in rabbits fed high fat diet
... significantly increased the GSH levels. The increased GSH concentration may be due to enhanced the synthesis of glutathione. Hence it is concluded that administration of flavonoids from Dolichos biflorus manifests ...
6
Effects of the pharmaceutical contaminants ibuprofen, diclofenac, and carbamazepine alone, and in combination, on oxidative stress parameters in early life stages of tench (Tinca tinca)
... ABSTRACT: In the present study, the effects of sub-lethal sub-chronic doses of ibuprofen, diclofenac, and car- bamazepine alone, and in combination (concentration range 0.02–60 µg/l), on the early life stages of tench ...
8
Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model
... of glutathione reductase (GR) and glutathione-S-transferase (GST) was determined suggesting increasing activity of GR with the amount of applied Cd for all three strains, whereas ambiguous results have been ...
9
Increased oxidative stress and altered antioxidants status in patients with chronic allergic rhinitis
... hour and 2 hours. Aliquots were drawn from the above mixture at 0 hour and 2 hours. Lipid peroxidation in RBC was determined by estimating malondialdehyde (MDA) produced using thiobarbituric acid [11]. Eryth- rocyte GR ...
6
A sensor for investigating the interaction between biologically important heavy metals and glutathione
... prokaryotic organisms. Thanks to its thiol group GSH is a potent reducing agent, which is involved in the detoxification of various electrophilic compounds and peroxides as a cofactor of glutathione-S-transferases ...
7
HUMAN GLUTATHIONE S-TRANSFERASE A1-1 BINDING WITH NATURALLY OCCURRING LIGANDS: ASSESSMENT BY DOCKING SIMULATIONS
... International Journal of Pharmacognosy 463 FIG. 7(A-B): (A): THE CINNAMIC ACID BINDING SITE RESIDUES. (B): THE IODOACETAMIDE BINDING SITE RESIDUES. THESE RESIDUES ARE IDENTIFIED USING GLUTATHIONE S-TRANSFERASE ...
8
Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia
... GSH depletion may also play a role in the increased male to female ratio observed in ...reduced glutathione, mitochondria from males, when compared to females, are more vulnerable to oxidative stress ...and ...
9
Effect of Atrazine on Glutathione Levels, Glutathione S-Transferase and Glutathione Reductase Activities in Pea and Wheat Plants
... Free thiol group contents in treated pea plants were higher than in the control plants, following a tendency similar to that of the total glutathione (Figure 1A and 1E). In contrast, free thiol group contents in ...
5
Erythrocyte glutathione synthetase deficiency leads not only to glutathione but also to glutathione S transferase deficiency
... Glutathione synthetase (GSH-S) is one of the two known hereditary causes of glutathione deficiency. We describe a family whose two children have hemolytic anemia. The children's erythrocytes lack GSH and ...
5
Protective Effect of Nardostachys jatamansi Against Radiation-induced Damage at Biochemical and Chromosomal Levels in Swiss Albino Mice
... in glutathione, total antioxidants and antioxidant enzymes such as glutathione peroxidase and catalase ...significant depletion in lipid peroxidation followed by significant elevation in reduced ...
6