glutathione-s-transferases
Practical Agar Based Disk Potentiation Test for Detection of Fosfomycin Nonsusceptible Escherichia coli Clinical Isolates Producing Glutathione S Transferases
... T he increased emergence of multidrug-resistant (MDR) patho- genic bacteria is becoming a serious public health concern, as MDR bacteria limit the choice of antimicrobials available for treatment (1). In such a ...
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POLYMORPHIC DELETIONS OF GLUTATHIONE S TRANSFERASES M1, T1 AND BLADDER CANCER RISK IN ALGERIAN POPULATION
... Following smoking, occupational exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAHs) are other important risk factors [10]. Increasing evidence suggests a significant influence of genetic polymorphism ...
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Relationship of Podoplanin and Glutathione S-transferases T1 Expression with Laryngeal Cancer
... The glutathione S- transferases (GST) are a family of detoxification and Glutathione S-transferase T1 (GST-T1) is a subgroup of the glutathione S-transferases (GST) ...
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Molecular genetic analysis of human mu class glutathione s-transferases
... cytosolic glutathione S-transferases (GSTs; EC ...G S T mu class genomic sequences were used as probes in Southern blot analyses and confirmed the correlation between the lack of a D NA ...
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Is there association between Glutathione S Transferases polymorphisms and cataract risk: a meta-analysis?
... It has been reported that oxidative stress contributes to development of age-related cataract [7]. Biochemical evidence demonstrates that generation of excessive re- active oxygen species (ROS) results in abnormal ...
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GLUTATHIONE S TRANSFERASES: A BRIEF ON CLASSIFICATION AND GSTM1 T1 ACTIVITY
... Classification of GSTs: The glutathione S- transferases (EC 2.5.1.18) are isoenzymes superfamilies that detoxify toxic substances are widely distributed in nature. 14, 15 Classified under two ...
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Adverse influence of β-methylcholanthrene on detoxification function of chick embryo brain glutathione S-transferases and degenerative changes of brain
... The exposure of PAHs to developing brain is very common in case of maternal cigarette smoking during pregnancy (Rodgman et al., 2000; Polanska et al., 2009). It was studied that the maternal cigarette smoking as well as ...
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Prognostic Significance of Comparison of Clinical Indicators with Manifestations of Genetic Polymorphism of Glutathione S Transferases in Non Small Cell Lung Cancer
... However, there is a multidirectional effect of GSTT1 genetic polymorphism on the survival of patients with different histological types of lung cancer: the survival median in carriers of[r] ...
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Glutathione S transferases play a role in the detoxification of flumethrin and chlorpyrifos in Haemaphysalis longicornis
... The HlGST2 gene showed overexpression at the high- est sublethal dose of chlorpyrifos (Fig. 1a). However, it is well known that organophosphates are metabolized by cytochrome P450 monooxygenases and hydrolases. Spe- ...
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Characterisation of Dermanyssus gallinae glutathione S transferases and their potential as acaricide detoxification proteins
... In this study we have identified the repertoire of Deg- GSTs in a transcriptomic dataset and selected and 2 mu class and one delta class Deg-GST for further character- isation. We have shown that several commonly used ...
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Characterization of glutathione S transferases from the pine wood nematode, Bursaphelenchus xylophilus
... In a previous study, we identified two secreted GSTs expressed in the dorsal pharyngeal gland cell of the pinewood nematode PWN, Bursaphelenchus xylophilus, which are upregulated post in[r] ...
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Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity
... Methods: GST alpha, pi and mu were investigated by immunohistochemistry in 72 lung tissue specimens and by Western analysis in total lung homogenates and induced sputum supernatants fro[r] ...
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Original Article Predictive potential role of glutathione S-transferases polymorphisms on prognosis of breast cancer
... All the patients were asked to provide 5 ml venous blood, and the genomic DNA was iso- lated using a Qiagen Blood Kit (Qiagen, Chastworth, CA) according to the manufactur- er’s instructions. Genotyping of GSTP1 rs1695, ...
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The molecular genetics and evolution of the Glutathione S-transferases
... 186 MMGST7 RNGST7 HSGSTPl BTGSTPl SSGSTPl CEGSTPl MAGSTMl HSGSTM4 HSGSTMS HSGSTMlb HSGSTM2 HSGSTMla HSGSTM3 RNGST4 RNGST3 CLGSTl GGGSTM2 MMGST3 MMGST4 SJGSTl SMGSTl FHGSTl OCGSTAl OCGSTA[r] ...
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Increased transcription of Glutathione S transferases in acaricide exposed scabies mites
... Levels of transcription of 6 GST genes as well as a P- glycoprotein and pH-gated chloride channel were analy- sed. The GSTs had been previously identified from sca- bies mite expressed sequence tag libraries and belong ...
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Journal of Applied Pharmaceutical Science
... The present study was aimed to analyse the effect of acrylamide and Hybanthus enneaspermus leaf extract active principles on mice testis glutathione-s-transferases (GST; EC 2.5.1.18). These enzymes ...
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Can GSTM1 and GSTT1 polymorphisms predict clinical outcomes of chemotherapy in gastric and colorectal cancers? A result based on the previous reports
... between glutathione S-transferases M1 or T1 polymorphisms and chemotherapy in gastrointestinal cancers using the following search terms: “gastric or stomach or col- orectal or colon or rectal,” ...
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HERB DRUG INTERACTION: AN OVERVIEW
... Although drug interactions can involve enzymes such as glutathione S-transferases and uridine diphosphoglucuronyl transfereases UGTs, most herbal drug interactions are related to oxidati[r] ...
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Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population
... Glutathione S-transferases (GSTs) represent a superfamily of phase II metabolic enzymes that catalyze the conjugation between glutathione and chemotherapeutic drugs, carcino- gens, ...
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HUMAN GLUTATHIONE S-TRANSFERASE A1-1 BINDING WITH NATURALLY OCCURRING LIGANDS: ASSESSMENT BY DOCKING SIMULATIONS
... ABSTRACT: Glutathione S-transferases are phase-II enzymes associated with detoxification and resistance to drugs and ...class Glutathione S-Transferase ...using Glutathione ...
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