Glycogen synthase
Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle
... changed glycogen phosphorylase ...regulates glycogen synthesis by a mechanism that involves dephosphorylation of glycogen synthase but not ...low glycogen synthase activities ...
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Pre eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles
... of glycogen breakdown ...in glycogen content (223 +/- 117 micrograms glycogen/mg protein), when compared with controls matched for gestational age at delivery (23 +/- 18 micrograms glycogen/mg ...
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Phosphoproteomic Characterization Of Glycogen Synthase Kinase-3
... Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed kinase that acts as a critical regulator of many signaling pathways. These pathways, when dysregulated, have been ...
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Impaired insulin stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity
... of glycogen synthase phosphatase as a possible mediator of reduced glycogen synthase activity, we studied 30 Southwestern American Indians with a broad range of insulin action in ...
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Glycogen synthase kinase-3 is required for axon growth and development
... Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine ...inhibits glycogen synthase downstream of insulin signaling (Embi et ...
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Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
... Since the isolation of GSK-3 from rabbit skeletal muscle in 1980,[17] its role and participation in glu- cose metabolism has been extensively studied. How- ever, GSK-3 was considered a therapeutic target for diabetes ...
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Glycogen synthase kinase 3: cryoprotection and glycogen metabolism in the freeze tolerant wood frog
... extensive glycogen hydrolysis and distribution of high concentrations of the cryoprotectant glucose into blood and all ...that glycogen synthase kinase-3 (GSK-3) would be activated when wood frogs ...
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Glycogen synthase: a putative locus for diet induced hyperglycemia
... the glycogen synthase gene (Gys) recently suggested as a candidate locus by analyses of type 2 diabetes ...Fractional glycogen synthase activity in isolated muscle was significantly lower in ...
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Correlation between muscle glycogen synthase activity and in vivo insulin action in man
... muscle glycogen content, and muscle glycogen synthase activity in 25 southwest American Indians with normal glucose tolerance and with varying degrees of glucose ...Muscle glycogen content and ...
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A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase
... are glycogen synthase kinase 3β (GSK3β) (which phosphorylates sites 3a, 3b, 3c, and 3d) and AMP-activated protein kinase (AMPK), which phosphorylates GS at site ...
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Regulation of Flagellar Assembly by Glycogen Synthase Kinase 3 in Chlamydomonas reinhardtii
... of glycogen synthase kinase 3 (GSK3), induced flagellar elongation, suggesting that a lithium-sensitive signal transduction pathway regulated flagel- lar length ...
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Intracellular glucose oxidation and glycogen synthase activity are reduced in non insulin dependent (type II) diabetes independent of impaired glucose uptake
... mmol/liter. By raising the concentration of either serum glucose or insulin fourfold in the NIDDM subjects, glucose uptake was matched to nondiabetic subjects (8.62 +/- 0.49 and 8.59 +/- 0.51 mg/kg FFM per min, ...
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BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC AGENT
... This interest has been heightened by the report that the level and activity of GSK-3β is moderately elevated in diabetic and obese strains of mice. Investigators at GlaxoSmithKline have recently developed a class of ...
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Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non insulin dependent diabetes mellitus
... muscle glycogen synthase and reduced glycogen formation in non-insulin dependent diabetes mellitus (NIDDM), glycogen synthase activity was kinetically analyzed during the basal state ...
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Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase Evidence for their role in oxidative and nonoxidative glucose metabolism
... of glycogen synthase (GS), phosphofructokinase (PFK), or pyruvate dehydrogenase (PDH) in skeletal muscle regulates intracellular glucose metabolism, subjects were studied basally and during euglycemic ...
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Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle
... Muscle glycogen synthesis was reduced by approximately 80% in diabetic rats (P less than ...treatment. Glycogen synthase activity was reduced in skeletal muscle of diabetic rats (P less than ...
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Quantification of the glycogen cascade system: the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs
... 3A shows that the fractional activation of GS exhibits a steeper response with an apparent Hill coefficient of 13.6, while GP demonstrates a response with an apparent Hill coefficient of 6.3 with respect to glucose. The ...
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Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0
... The glycogen synthase (GS) activity has been low or immeasurable in liver biopsies, whereas the liver glycogen content has been only moderately ...
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Glycogen Synthase Kinase-3β (GSK-3β) and Nuclear Factor Kappa-B (NFKB) in Childhood Acute Lymphoblastic Leukemia
... Glycogen synthase kinase 3 (GSK-3) is a ser- ine/tyrosine kinase identified in skeletal muscle. To date, two isoforms of GSK-3 have been reported: the first, 51 kDa (GSK-3α), and the second, 47 kDa ...
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Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer
... After AZD1080 treatment, the mRNA expression of GSK-3 β , CDK2, CDK1, cyclin D1, MMP9, and Bcl-xL in the two ovarian carcinoma cell lines was lower than that in the control c[r] ...
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