glycogen synthase kinase
Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
... Glycogen synthase kinase-3 (GSK-3) is expressed in all tissues and is a member of the protein kinase family, a group of enzymes that catalyze the transfer of a phosphate group from adenosine ...
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Glycogen synthase kinase 3: cryoprotection and glycogen metabolism in the freeze tolerant wood frog
... of glycogen synthase kinase-3 (GSK-3), a protein kinase that, when active, phosphorylates and inactivates GS (Sutherland et ...in glycogen metabolism, GSK-3 has been shown to be a ...
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Glycogen Synthase Kinase-3β (GSK-3β) and Nuclear Factor Kappa-B (NFKB) in Childhood Acute Lymphoblastic Leukemia
... Glycogen synthase kinase 3 (GSK-3) is a ser- ine/tyrosine kinase identified in skeletal muscle. To date, two isoforms of GSK-3 have been reported: the first, 51 kDa (GSK-3α), and the second, ...
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Regulation of Flagellar Assembly by Glycogen Synthase Kinase 3 in Chlamydomonas reinhardtii
... of glycogen synthase kinase 3 (GSK3), induced flagellar elongation, suggesting that a lithium-sensitive signal transduction pathway regulated flagel- lar length ...its kinase activity is ...
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Activation of GABAB receptors inhibits protein kinase B /Glycogen Synthase Kinase 3 signaling
... Accumulated evidence has suggested that potentiation of cortical GABAergic inhibitory neurotransmission may be a key mechanism in the treatment of schizophrenia. However, the downstream molecular mechanisms related to ...
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The role of glycogen synthase kinase-3β in glioma cell apoptosis induced by remifentanil
... activated glycogen synthase kinase-3β (GSK-3β) [7, ...serine/threonine kinase that regulates numerous signaling pathways involved in cell cycle control and cell proliferation, differentiation ...
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Phosphoproteomic Characterization Of Glycogen Synthase Kinase-3
... Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed kinase that acts as a critical regulator of many signaling ...direct kinase assays or genetic and ...
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BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC AGENT
... inactivated glycogen synthase, the final enzyme in glycogen ...the kinase core (308 residues), but the core has 97% sequence similarity and overall 91% ...identity. Glycogen ...
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Glycogen synthase kinase-3 is required for axon growth and development
... Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine ...regulatory kinase that phosphorylates and inhibits glycogen synthase downstream ...
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Integrin Linked Kinase Is a Functional Mn2+ Dependent Protein Kinase that Regulates Glycogen Synthase Kinase 3β (GSK 3β) Phosphorylation
... impaired kinase activity. Indeed, the crystal structure of the ILK kinase domain in complex with a-parvin indicates that the K220 ATP- binding motif is well separated from the a-parvin-contacting residues, ...
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Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer
... protein kinase activ- ity, promoting cell cycle phase transition, initiating DNA synthesis, and regulating cellular transcription and other functions; for example, CDK1 and cyclin B1 accelerate cell division and ...
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SYNTHESIS & PREDICTING THE POSSIBILITY OF 2, 5 DISUBSTITUTED 1, 3, 4 OXADIAZOLE DERIVATIVES AS GSK 3β INHIBITORS
... 3F7Z Protein Preparation: Docking calculations were carried out on 2PRG protein model. Essential hydrogen atoms, Kollman united atom type charges, and solvation parameters were added with the aid of AutoDock tools 25 ...
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Mechanism and evolution of cytosolic Hedgehog signal transduction
... casein kinase I; Cos2, Costal2; FL, full-length; Fu, Fused; GSK3, glycogen synthase kinase 3; Hh, Hedgehog; Kif7, kinesin family member 7; P, phosphate group; PKA, protein kinase A; R, ...
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Novel Roles for the Tumor Suppressor APC Through Regulation of GSK-3
... Huang, J., Zhang, Y., Bersenev, A., O’Brien, W.T., Tong, W., Emerson, S.G., and Klein, P.S. (2009b). Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice. ...
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Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway
... Results: We used AF that was extracted from embryos at 16 days in pregnant SD rat and exposed the AF to the neural cells derived from the embryos of same rat. We found that the treatment of AF to cortical neurons ...
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Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
... particular, glycogen synthase kinase-3β (GSK-3β) plays a key role in the neuronal response to stress by phosphorylating and compromising the transcriptional activity of the cAMP re- sponse element ...
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Cell migration in paediatric glioma; characterisation and potential therapeutic targeting
... inhibition. Glycogen synthase kinase-3 is thought to be involved in the control of cell migration, through its role in regulating cellular structure alongside microtubule and focal adhesion dynamics ...
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The traditional Chinese formulae Ling gui zhu gan decoction alleviated non alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules
... affect glycogen metabolism [8], which is the primary storage form of excess ...mediate glycogen metabolism ...to glycogen (PTG) [10]. PTG overexpression can increase glycogen storage ...
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Inhibitory interactions of Coenzyme Q10 with selected key enzymes of glucose metabolism: An in silico approach
... Human glycogen synthase kinase 3-β helps in pathogenesis of oxidative stress, mitochondrial dysfunction and disorders related to central nervous system ...
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Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway
... of glycogen and lipids is the primary means by which the body stores excess nutrients and is strictly controlled by a complex network of hormones and metabolic ...conditions, glycogen is the primary storage ...
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