GLYCOGEN-SYNTHASE-KINASE-3
Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens
... Glycogen synthase kinase 3 (GSK3), in its two isoforms GSK3 α and GSK3 β , is a multifunctional Ser/Thr kinase found in eukaryotes ...as glycogen metabolism, cell cycle con- ...
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A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP
... The Kaposi’s sarcoma-associated herpesvirus (KSHV) LANA protein is essential for the replication and maintenance of virus genomes in latently KSHV-infected cells. LANA also drives dysregulated cell growth through a ...
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In Silico Analysis of Glycogen Synthase Kinase 3-Beta (GSK-3β) As Aflatoxin Binder
... Glycogen Synthase Kinase 3-beta (GSK- 3â) was first identified as a negative regulator of glycogenesis and subsequently reported to regulate varies signalling pathway and cellular ...
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Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain
... Recently, glycogen synthase kinase-3 (GSK3) was identi- fied as a crucial regulator of innate inflammatory proc- esses ...Ser/Thr kinase consisting of two isoforms, GSK3α and ...
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Glycogen synthase kinase 3: cryoprotection and glycogen metabolism in the freeze tolerant wood frog
... extensive glycogen hydrolysis and distribution of high concentrations of the cryoprotectant glucose into blood and all ...that glycogen synthase kinase-3 (GSK-3) would be ...
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Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia
... pathways, glycogen synthase kinase 3 (GSK3), a component of the wnt/wingless pathway that regulates many cell fate decisions in metazoa [14, 15], is in ...
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Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice
... that glycogen synthase kinase–3 (Gsk3) plays a pivotal role in controlling the decision between self renewal and differentiation of ...
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Molecular Docking Studies Involving the Inhibitory Effect of Gymnemic Acid, Trigonelline and Ferulic Acid, the Phytochemicals with Antidiabetic Properties, on Glycogen Synthase Kinase 3 (α and β)
... rats. Glycogen metabolism plays an important role in the regulation of glucose homeostasis and it is controlled by the two rate-limiting enzymes namely glycogen synthase and glycogen ...of ...
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BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC AGENT
... Cite This Article: Jeeven S. Solanki, Arpan Bhardwaj, Amit padidar, Kalpana Singh, and RekhaNagwanshi. (2017). “BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC ...
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Phosphoproteomic Characterization Of Glycogen Synthase Kinase-3
... Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed kinase that acts as a critical regulator of many signaling ...direct kinase assays or ...
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Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer
... Methods: A2780 and OVCAR3 ovarian cancer cell lines were exposed to AZD1080, after which cell proliferation, cell cycle, invasion, and migration assays were performed. Phalloidin staining was used to observe lamellipodia ...
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Clinicopathological and biological significance of aberrant activation of glycogen synthase kinase-3 in ovarian cancer
... a 3-day exposure to GSK-3-specific siRNAs, immunoblotting showed $70% reduction in expression levels of the corresponding GSK-3 isoforms when compared to untransfected or scrambled siRNA transfected ...
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Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus.
... Here we studied the effect of the serine/threonine kinase GSK3 during mammalian neural crest migration. Previously, we have found that GSK3β is required for the palate formation at specific time points during ...
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The regulation of constitutive NF-[kappa]B activity by glycogen synthase kinase-3 in pancreatic cancer
... protein kinase C (PKC) represents a potential alternative kinase that can phosphorylate TAK1 at serine ...this kinase in regulating constitutive TAK1 (S412) phosphorylation and downstream NF-κB ...
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Activation of GABAB receptors inhibits protein kinase B /Glycogen Synthase Kinase 3 signaling
... Accumulated evidence has suggested that potentiation of cortical GABAergic inhibitory neurotransmission may be a key mechanism in the treatment of schizophrenia. However, the downstream molecular mechanisms related to ...
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Glycogen synthase kinase-3 is required for axon growth and development
... In multicellular organisms, GSK-3 functions in several distinct signaling pathways (Doble and Woodgett, 2003; Woodgett, 2001). In response to growth factors such as FGF and NGF, phosphorylation of GSK-3 ...
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Regulation of Flagellar Assembly by Glycogen Synthase Kinase 3 in Chlamydomonas reinhardtii
... The cDNA contains a single open reading frame of 1,044 nucleotides encoding a 347-amino-acid protein with a pre- dicted pI of 8.65 and a predicted molecular mass of 43.5 kDa. GSK3 is encoded by a single gene, based on a ...
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Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
... of glycogen synthase (GS), an enzyme that mediates the conversion of glucose to ...PI3 kinase (phosphatidylinositol-4, 5-bisphosphate 3-kinase)/PKB (protein kinase B) ...of ...
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Mechanism and evolution of cytosolic Hedgehog signal transduction
... protein kinase A (PKA), casein kinase I (CKI) and glycogen synthase kinase 3 (GSK3), targeting the proteins for proteasome- dependent processing (Bhatia et ...
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Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway
... Results: We used AF that was extracted from embryos at 16 days in pregnant SD rat and exposed the AF to the neural cells derived from the embryos of same rat. We found that the treatment of AF to cortical neurons ...
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